Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
July-2026 Volume 32 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2026 Volume 32 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Impact of vitamin D receptor gene variants on psoriasis vulgaris susceptibility and clinical phenotype in a Greek population

  • Authors:
    • Polytimi Sidiropoulou
    • Martha Katsarou
    • Maria Papasavva
    • Annia Tsolakou
    • Akylas Fotiadis
    • Demetrios A. Spandidos
    • Natalia Rompoti
    • Irene Stefanaki
    • Alexander J. Stratigos
    • Nikolaos Drakoulis
    • Electra Nicolaidou
  • View Affiliations / Copyright

    Affiliations: 1st Department of Dermatology‑Venereology, Medical School, National and Kapodistrian University of Athens, ‘A. Sygros’ Hospital for Skin and Venereal Diseases, 16121 Athens, Greece, Research Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, 15771 Athens, Greece, Department of Electrical and Computer Engineering, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece, Laboratory of Clinical Virology, Medical School, University of Crete, 71003 Heraklion, Greece
    Copyright: © Sidiropoulou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 193
    |
    Published online on: May 19, 2026
       https://doi.org/10.3892/etm.2026.13188
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:


Abstract

Psoriasis vulgaris (PsV) is a complex immune-mediated disease with a polygenic component. Common variants in the vitamin D receptor (VDR) gene have been explored in the context of psoriasis, but findings remain inconsistent and data from the Greek population are scarce. Thus, the present study aimed to investigate the association of the VDR FokI (rs2228570), BsmI (rs1544410) and TaqI (rs731236) single‑nucleotide polymorphisms (SNPs) with PsV susceptibility and clinical phenotype in a Caucasian Greek cohort. In this observational cross‑sectional study, 203 patients with chronic plaque psoriasis and 812 age‑, sex‑ and ethnically‑matched controls of Greek origin were genotyped for the selected VDR SNPs using real‑time PCR (melting curve analysis) and SNP‑based statistical comparisons were performed. Case‑control analyses exhibited a significant association between the BsmI variant and PsV susceptibility under the recessive and allelic models, with the A allele (A vs. G; OR: 0.765; 95% CI: 0.614‑0.953; adjusted P=0.032) and AA genotype (AA vs. GA + GG; OR: 0.577; 95% CI: 0.386‑0.861; adjusted P=0.028) conferring a protective effect. No impact on PsV risk was observed for FokI or TaqI. Intra‑patient subgroup analyses based on clinical traits indicated phenotype‑specific contributions: FokI was associated with early‑onset and familial disease, TaqI with psoriatic arthritis and both BsmI and TaqI with nail involvement. To the best of our knowledge, this study provides the first evidence that VDR genetic variation may influence PsV susceptibility and clinical expression in the Greek population. The VDR locus could thus serve as a potential biomarker for tailored risk stratification and clinical profiling in PsV. Further large‑scale studies integrating genotypic and phenotypic data, especially among Caucasians, are required to validate these findings.
View Figures

Figure 1

Summary of the main effects of
vitamin D on skin barrier, immunity and vascularization. TJ, tight
junctions; Th, T helper; JAK/STAT, Janus kinase/signal transducer
and activator of transcription.

Figure 2

Graphical abstract summarizing the
study design and main findings. BsmI was associated with PsV
susceptibility, while VDR variants were associated with key
clinical features, including age at onset (FokI), nail psoriasis
(BsmI and TaqI), psoriatic arthritis (TaqI) and familial clustering
(FokI). PsV, psoriasis vulgaris; VDR, vitamin D receptor.
View References

1 

Griffiths CEM, Armstrong AW, Gudjonsson JE and Barker JNWN: Psoriasis. Lancet. 397:1301–1315. 2021.PubMed/NCBI View Article : Google Scholar

2 

Damiani G, Bragazzi NL, Karimkhani Aksut C, Wu D, Alicandro G, McGonagle D, Guo C, Dellavalle R, Grada A, Wong P, et al: The global, regional, and national burden of psoriasis: Results and insights from the global burden of disease 2019 study. Front Med (Lausanne). 8(743180)2021.PubMed/NCBI View Article : Google Scholar

3 

Zhang M, Su W, Deng J, Zhai B, Zhu G, Gao R, Zeng Q, Qiu J, Bian Z, Xiao H, et al: Multi-ancestry genome-wide meta-analysis with 472,819 individuals identifies 32 novel risk loci for psoriasis. J Transl Med. 23(133)2025.PubMed/NCBI View Article : Google Scholar

4 

Singh S, Pradhan D, Puri P, Ramesh V, Aggarwal S, Nayek A and Jain AK: Genomic alterations driving psoriasis pathogenesis. Gene. 683:61–71. 2019.PubMed/NCBI View Article : Google Scholar

5 

Brożyna AA, Slominski RM, Nedoszytko B, Zmijewski MA and Slominski AT: Vitamin D signaling in psoriasis: Pathogenesis and therapy. Int J Mol Sci. 23(8575)2022.PubMed/NCBI View Article : Google Scholar

6 

Gisondi P, Gracia-Cazaña T, Kurzen H and Galván J: Calcipotriol/Betamethasone dipropionate for the treatment of psoriasis: Mechanism of action and evidence of efficacy and safety versus topical corticosteroids. J Clin Med. 13(4484)2024.PubMed/NCBI View Article : Google Scholar

7 

Visconti B, Paolino G, Carotti S, Pendolino AL, Morini S, Richetta AG and Calvieri S: Immunohistochemical expression of VDR is associated with reduced integrity of tight junction complex in psoriatic skin. J Eur Acad Dermatol Venereol. 29:2038–2042. 2015.PubMed/NCBI View Article : Google Scholar

8 

Liang W, Lin Z, Zhang L, Qin X, Zhang Y and Sun L: Calcipotriol inhibits proliferation of human keratinocytes by downregulating STAT1 and STAT3 signaling. J Investig Med. 65:376–381. 2017.PubMed/NCBI View Article : Google Scholar

9 

Cao M, Mei L, Xiao M, Li J and Fang F: Calcipotriol inhibits psoriasis-like angiogenic features in K14-VEGF transgenic mice. Eur J Dermatol. 32:24–33. 2022.PubMed/NCBI View Article : Google Scholar

10 

Slominski AT, Kim TK, Janjetovic Z, Slominski RM, Li W, Jetten AM, Indra AK, Mason RS and Tuckey RC: Biological Effects of CYP11A1-Derived Vitamin D and Lumisterol Metabolites in the Skin. J Invest Dermatol. 144:2145–2161. 2024.PubMed/NCBI View Article : Google Scholar

11 

Zhang Y, Jing D, Zhou G, Xiao Y, Shen M, Chen X and Liu H: Evidence of a causal relationship between vitamin D status and risk of psoriasis from the UK Biobank study. Front Nutr. 9(807344)2022.PubMed/NCBI View Article : Google Scholar

12 

Lee YH and Song GG: Association between circulating 25-hydroxyvitamin D levels and psoriasis, and correlation with disease severity: A meta-analysis. Clin Exp Dermatol. 43:529–535. 2018.PubMed/NCBI View Article : Google Scholar

13 

Elmelid A, Siekkeri Vandikas M, Gillstedt M, Osmancevic A and Alsterholm M: The effect of narrow-band ultraviolet B phototherapy on free and total vitamin D serum levels in mild to severe plaque psoriasis. Biomolecules. 13(1018)2023.PubMed/NCBI View Article : Google Scholar

14 

Elgarhy LH, Eltatawy RA, Rizk O and Ismail M: Vitamin D receptor expression in chronic plaque psoriasis before and after narrowband ultraviolet B phototherapy. J Cutan Aesthet Surg. 16:128–133. 2023.PubMed/NCBI View Article : Google Scholar

15 

Lee YH: Vitamin D receptor ApaI, TaqI, BsmI, and FokI polymorphisms and psoriasis susceptibility: An updated meta-analysis. Clin Exp Dermatol. 44:498–505. 2019.PubMed/NCBI View Article : Google Scholar

16 

Agliardi C, Guerini FR, Bolognesi E, Zanzottera M and Clerici M: VDR gene single nucleotide polymorphisms and autoimmunity: A narrative review. Biology (Basel). 12(916)2023.PubMed/NCBI View Article : Google Scholar

17 

Poon AH, Gong L, Brasch-Andersen C, Litonjua AA, Raby BA, Hamid Q, Laprise C, Weiss ST, Altman RB and Klein TE: Very important pharmacogene summary for VDR. Pharmacogenet Genomics. 22:758–763. 2012.PubMed/NCBI View Article : Google Scholar

18 

Uitterlinden AG, Fang Y, Van Meurs JB, Pols HA and Van Leeuwen JP: Genetics and biology of vitamin D receptor polymorphisms. Gene. 338:143–156. 2004.PubMed/NCBI View Article : Google Scholar

19 

Saccone D, Asani F and Bornman L: Regulation of the vitamin D receptor gene by environment, genetics and epigenetics. Gene. 561:171–180. 2015.PubMed/NCBI View Article : Google Scholar

20 

Andraos C, Koorsen G, Knight JC and Bornman L: Vitamin D receptor gene methylation is associated with ethnicity, tuberculosis, and TaqI polymorphism. Hum Immunol. 72:262–268. 2011.PubMed/NCBI View Article : Google Scholar

21 

Stefanic M, Rucevic I and Barisic-Drusko V: Meta-analysis of vitamin D receptor polymorphisms and psoriasis risk. Int J Dermatol. 52:705–710. 2013.PubMed/NCBI View Article : Google Scholar

22 

Liu JL, Zhang SQ and Zeng HM: ApaI, BsmI, FokI and TaqI polymorphisms in the vitamin D receptor (VDR) gene and the risk of psoriasis: A meta-analysis. J Eur Acad Dermatol Venereol. 27:739–746. 2013.PubMed/NCBI View Article : Google Scholar

23 

Lee YH, Choi SJ, Ji JD and Song GG: Vitamin D receptor ApaI, TaqI, BsmI, and FokI polymorphisms and psoriasis susceptibility: A meta-analysis. Mol Biol Rep. 39:6471–6478. 2012.PubMed/NCBI View Article : Google Scholar

24 

European Medicines Agency: Position paper on terminology in pharmacogenetics. EMEA/CPMP/3070/01. EMEA, London, 2002. Available at: https://www.ema.europa.eu/en/documents/scientific-guideline/position-paper-terminology-pharmacogenetics_en.pdf.

25 

Strober B, Ryan C, van de Kerkhof P, van der Walt J, Kimball AB, Barker J and Blauvelt A: International Psoriasis Council Board Members and Councilors. Recategorization of psoriasis severity: Delphi consensus from the International Psoriasis Council. J Am Acad Dermatol. 82:117–122. 2020.PubMed/NCBI View Article : Google Scholar

26 

AbdElneam AI, Al-Dhubaibi MS, Bahaj SS and Mohammed GF: The vitamin D receptor gene polymorphism rs1544410 T/T genotype as a predictor of factor vitamin D thresholds deficiency in patients with psoriasis vulgaris-A preliminary study. J Cosmet Dermatol. 22:1642–1646. 2023.PubMed/NCBI View Article : Google Scholar

27 

Saeki H, Asano N, Tsunemi Y, Takekoshi T, Kishimoto M, Mitsui H, Tada Y, Torii H, Komine M, Asahina A and Tamaki K: Polymorphisms of vitamin D receptor gene in Japanese patients with psoriasis vulgaris. J Dermatol Sci. 30:167–171. 2002.PubMed/NCBI View Article : Google Scholar

28 

Li J, Sun L, Sun J and Yan M: Pooling analysis regarding the impact of human vitamin D receptor variants on the odds of psoriasis. BMC Med Genet. 20(161)2019.PubMed/NCBI View Article : Google Scholar

29 

A Anani HA, Khalifa WA, Althoqapy AA, Maklad SS, Kamal H, Sabry D and Samir M: Frequency of genotypes and allelic polymorphisms of vitamin D receptor in egyptian psoriatic patients and their association with disease severity, immune modulation of IL-22 levels and the response to topical calcipotriol treatment: A case control study. Indian J Dermatol. 67:37–44. 2022.PubMed/NCBI View Article : Google Scholar

30 

Liu J, Wang W, Liu K, Wan D, Wu Z, Cao Z, Luo Y, Xiao C and Yin M: Vitamin D receptor gene polymorphisms are associated with psoriasis susceptibility and the clinical response to calcipotriol in psoriatic patients. Exp Dermatol. 29:1186–1190. 2020.PubMed/NCBI View Article : Google Scholar

31 

Rucevic I, Stefanic M, Tokic S, Vuksic M, Glavas-Obrovac L and Barisic-Drusko V: Lack of association of vitamin D receptor gene 3'-haplotypes with psoriasis in Croatian patients. J Dermatol. 39:58–62. 2012.PubMed/NCBI View Article : Google Scholar

32 

Polić MV, Rucević I, Barisić-Drusko V, Miskulin M, Glavas-Obrovac L, Stefanić M, Karner I, Lipozencić J, Bacun T and Mihaljević I: Polymorphisms of vitamin D receptor gene in the population of eastern Croatia with psoriasis vulgaris and diabetes mellitus. Coll Antropol. 36:451–457. 2012.PubMed/NCBI

33 

Zuel-Fakkar NM, Kamel MM, Asaad MK, Mahran MZ and Shehab AA: A study of ApaI and TaqI genotypes of the vitamin D receptor in Egyptian patients with psoriasis. Clin Exp Dermatol. 36:355–359. 2011.PubMed/NCBI View Article : Google Scholar

34 

Halsall JA, Osborne JE, Pringle JH and Hutchinson PE: Vitamin D receptor gene polymorphisms, particularly the novel A-1012G promoter polymorphism, are associated with vitamin D3 responsiveness and non-familial susceptibility in psoriasis. Pharmacogenet Genomics. 15:349–355. 2005.PubMed/NCBI View Article : Google Scholar

35 

Richetta AG, Silvestri V, Giancristoforo S, Rizzolo P, D'Epiro S, Graziano V, Mattozzi C, Navazio AS, Campoli M, D'Amico C, et al: A-1012G promoter polymorphism of vitamin D receptor gene is associated with psoriasis risk and lower allele-specific expression. DNA Cell Biol. 33:102–109. 2014.PubMed/NCBI View Article : Google Scholar

36 

Zhou X, Xu LD and Li YZ: The association of polymorphisms of the vitamin D receptor gene with psoriasis in the Han population of northeastern China. J Dermatol Sci. 73:63–66. 2014.PubMed/NCBI View Article : Google Scholar

37 

Acikbas I, Sanlı B, Tepeli E, Ergin S, Aktan S and Bagci H: Vitamin D receptor gene polymorphisms and haplotypes (Apa I, Bsm I, Fok I, Taq I) in Turkish psoriasis patients. Med Sci Monit. 18:CR661–6. 2012.PubMed/NCBI View Article : Google Scholar

38 

Ruggiero M, Gulisano M, Peruzzi B, Giomi B, Caproni M, Fabbri P and Pacini S: Vitamin D receptor gene polymorphism is not associated with psoriasis in the Italian Caucasian population. J Dermatol Sci. 35:68–70. 2004.PubMed/NCBI View Article : Google Scholar

39 

Okita H, Ohtsuka T, Yamakage A and Yamazaki S: Polymorphism of the vitamin D(3) receptor in patients with psoriasis. Arch Dermatol Res. 294:159–162. 2002.PubMed/NCBI View Article : Google Scholar

40 

Park BS, Park JS, Lee DY, Youn JI and Kim IG: Vitamin D receptor polymorphism is associated with psoriasis. J Invest Dermatol. 112:113–116. 1999.PubMed/NCBI View Article : Google Scholar

41 

Mee JB and Cork MJ: Vitamin D receptor polymorphism and calcipotriol response in patients with psoriasis. J Invest Dermatol. 110:301–302. 1998.PubMed/NCBI View Article : Google Scholar

42 

Kontula K, Välimäki S, Kainulainen K, Viitanen AM and Keski-Oja J: Vitamin D receptor polymorphism and treatment of psoriasis with calcipotriol. Br J Dermatol. 136:977–978. 1997.PubMed/NCBI View Article : Google Scholar

43 

Ohata C, Anezaki H, Kaneko S, Okazaki F, Ito K, Matsuzaka Y, Kikuchi S, Koike Y, Murota H, Miyagi T, et al: Clinical characteristics of patients with psoriasis with family history: A multicenter observational study. J Dermatol. 50:746–752. 2023.PubMed/NCBI View Article : Google Scholar

44 

Dayangac-Erden D, Karaduman A and Erdem-Yurter H: Polymorphisms of vitamin D receptor gene in Turkish familial psoriasis patients. Arch Dermatol Res. 299:487–491. 2007.PubMed/NCBI View Article : Google Scholar

45 

Neves JSF, Visentainer JEL, Reis DMDS, Rocha Loures MA, Alves HV, Lara-Armi FF, de Alencar JB, Valentin Zacarias JM and Sell AM: The Influence of Vitamin D Receptor Gene Polymorphisms in Spondyloarthritis. Int J Inflam. 2020(8880879)2020.PubMed/NCBI View Article : Google Scholar

46 

Langenbruch A, Radtke MA, Krensel M, Jacobi A, Reich K and Augustin M: Nail involvement as a predictor of concomitant psoriatic arthritis in patients with psoriasis. Br J Dermatol. 171:1123–1128. 2014.PubMed/NCBI View Article : Google Scholar

47 

Stuart PE, Nair RP, Tsoi LC, Tejasvi T, Das S, Kang HM, Ellinghaus E, Chandran V, Callis-Duffin K, Ike R, et al: Genome-wide association analysis of psoriatic arthritis and cutaneous psoriasis reveals differences in their genetic architecture. Am J Hum Genet. 97:816–836. 2015.PubMed/NCBI View Article : Google Scholar

48 

Meyer V, Saccone DS, Tugizimana F, Asani FF, Jeffery TJ and Bornman L: Methylation of the vitamin D receptor (VDR) Gene, together with genetic variation, race, and environment influence the signaling efficacy of the toll-like receptor 2/1-VDR pathway. Front Immunol. 8(1048)2017.PubMed/NCBI View Article : Google Scholar

49 

Stratigos AJ, Richard MA, Dessinioti C, Paul C, Nijsten T, Gisondi P, Salavastru C, Taieb C, Trakatelli M, Puig L, et al: The prevalence of skin diseases in Greece, impact on quality of life and stigmatization: A population-based survey study. JEADV Clin Pract. 3:591–599. 2024.

50 

Visscher PM, Wray NR, Zhang Q, Sklar P, McCarthy MI, Brown MA and Yang J: 10 Years of GWAS discovery: Biology, function, and translation. Am J Hum Genet. 101:5–22. 2017.PubMed/NCBI View Article : Google Scholar

51 

Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, et al: Finding the missing heritability of complex diseases. Nature. 461:747–753. 2009.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Sidiropoulou P, Katsarou M, Papasavva M, Tsolakou A, Fotiadis A, Spandidos DA, Rompoti N, Stefanaki I, Stratigos AJ, Drakoulis N, Drakoulis N, et al: Impact of vitamin D receptor gene variants on psoriasis vulgaris susceptibility and clinical phenotype in a Greek population. Exp Ther Med 32: 193, 2026.
APA
Sidiropoulou, P., Katsarou, M., Papasavva, M., Tsolakou, A., Fotiadis, A., Spandidos, D.A. ... Nicolaidou, E. (2026). Impact of vitamin D receptor gene variants on psoriasis vulgaris susceptibility and clinical phenotype in a Greek population. Experimental and Therapeutic Medicine, 32, 193. https://doi.org/10.3892/etm.2026.13188
MLA
Sidiropoulou, P., Katsarou, M., Papasavva, M., Tsolakou, A., Fotiadis, A., Spandidos, D. A., Rompoti, N., Stefanaki, I., Stratigos, A. J., Drakoulis, N., Nicolaidou, E."Impact of vitamin D receptor gene variants on psoriasis vulgaris susceptibility and clinical phenotype in a Greek population". Experimental and Therapeutic Medicine 32.1 (2026): 193.
Chicago
Sidiropoulou, P., Katsarou, M., Papasavva, M., Tsolakou, A., Fotiadis, A., Spandidos, D. A., Rompoti, N., Stefanaki, I., Stratigos, A. J., Drakoulis, N., Nicolaidou, E."Impact of vitamin D receptor gene variants on psoriasis vulgaris susceptibility and clinical phenotype in a Greek population". Experimental and Therapeutic Medicine 32, no. 1 (2026): 193. https://doi.org/10.3892/etm.2026.13188
Copy and paste a formatted citation
x
Spandidos Publications style
Sidiropoulou P, Katsarou M, Papasavva M, Tsolakou A, Fotiadis A, Spandidos DA, Rompoti N, Stefanaki I, Stratigos AJ, Drakoulis N, Drakoulis N, et al: Impact of vitamin D receptor gene variants on psoriasis vulgaris susceptibility and clinical phenotype in a Greek population. Exp Ther Med 32: 193, 2026.
APA
Sidiropoulou, P., Katsarou, M., Papasavva, M., Tsolakou, A., Fotiadis, A., Spandidos, D.A. ... Nicolaidou, E. (2026). Impact of vitamin D receptor gene variants on psoriasis vulgaris susceptibility and clinical phenotype in a Greek population. Experimental and Therapeutic Medicine, 32, 193. https://doi.org/10.3892/etm.2026.13188
MLA
Sidiropoulou, P., Katsarou, M., Papasavva, M., Tsolakou, A., Fotiadis, A., Spandidos, D. A., Rompoti, N., Stefanaki, I., Stratigos, A. J., Drakoulis, N., Nicolaidou, E."Impact of vitamin D receptor gene variants on psoriasis vulgaris susceptibility and clinical phenotype in a Greek population". Experimental and Therapeutic Medicine 32.1 (2026): 193.
Chicago
Sidiropoulou, P., Katsarou, M., Papasavva, M., Tsolakou, A., Fotiadis, A., Spandidos, D. A., Rompoti, N., Stefanaki, I., Stratigos, A. J., Drakoulis, N., Nicolaidou, E."Impact of vitamin D receptor gene variants on psoriasis vulgaris susceptibility and clinical phenotype in a Greek population". Experimental and Therapeutic Medicine 32, no. 1 (2026): 193. https://doi.org/10.3892/etm.2026.13188
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team