|
1
|
Zanon Zotin MC, Sveikata L, Viswanathan A
and Yilmaz P: Cerebral small vessel disease and vascular cognitive
impairment: From diagnosis to management. Curr Opin Neurol.
34:246–257. 2021.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Cheng YW, Chiu MJ, Chen YF, Cheng TW, Lai
YM and Chen TF: The contribution of vascular risk factors in
neurodegenerative disorders: From mild cognitive impairment to
Alzheimer's disease. Alzheimers Res Ther. 12(91)2020.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Markus HS and Joutel A: The pathogenesis
of cerebral small vessel diseases and vascular cognitive
impairment. Physiol Rev. 105:1075–1171. 2025.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Rajeev V, Chai YL, Poh L, Selvaraji S,
Fann DY, Jo DG, De Silva TM, Drummond GR, Sobey CG, Arumugam TV, et
al: Chronic cerebral hypoperfusion: A critical feature in
unravelling the etiology of vascular cognitive impairment. Acta
Neuropathol Commun. 11(93)2023.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Jiménez-Ruiz A, Aguilar-Fuentes V,
Becerra-Aguiar NN, Roque-Sanchez I and Ruiz-Sandoval JL: Vascular
cognitive impairment and dementia: A narrative review. Dement
Neuropsychol. 18(e20230116)2024.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Rundek T, Tolea M, Ariko T, Fagerli EA and
Cemargo CJ: Vascular cognitive impairment (VCI). Neurotherapeutics.
19:68–88. 2022.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Chang Wong E and Chang Chui H: Vascular
cognitive impairment and dementia. Continuum (Minneap Minn).
28:750–780. 2022.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Pérez Palmer N, Trejo Ortega B and Joshi
P: Cognitive impairment in older adults: Epidemiology, diagnosis,
and treatment. Psychiatr Clin North Am. 45:639–661. 2022.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Kalaria RN, Akinyemi RO, Paddick SM and
Ihara M: Current perspectives on prevention of vascular cognitive
impairment and promotion of vascular brain health. Expert Rev
Neurother. 24:25–44. 2024.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Xia CY, Zhou MM, Dong XW, Zhao Y, Jiang
MF, Zhu GQ and Zhang ZX: Ginkgo biloba extract inhibits
hippocampal neuronal injury caused by mitochondrial oxidative
stress in a rat model of Alzheimer's disease. PLoS One.
19(e0307735)2024.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Tang Z, Jiang DZ, Zhao XX and Zhang YW:
Comparison of different specifications of Ginkgo biloba
extract and discussion on specification improvement. Drug Stand
China. 21:21–25. 2020.
|
|
12
|
Liu J, Zhou J, Li WW, Chen YP and Wang J:
Effects of different doses of Ginkgo biloba extract on
cognitive function and neurotransmitter level in rats with vascular
cognitive impairment. Chin J Difficult Complicat Cases. 20:182–186.
2021.
|
|
13
|
Liu LM, Wang YT, Zhang JC and Wang SF:
Advances in the chemical constituents and chemical analysis of
Ginkgo biloba leaf, extract, and phytopharmaceuticals. J
Pharm Biomed Anal. 193(113704)2021.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Li XY and Liu AJ: Chemical constitution
and pharmacological mechanism of Ginkgo biloba extract 50 in
the treatment of vascular related diseases. Chin Pharm J.
59:1074–1081. 2024.
|
|
15
|
Qian YY, Zhu GQ, Wang WJ and Gao Q:
Research progress on the clinical and pharmacological effects of
Ginkgo biloba extract 50 and its preparations. Chin Tradit
Patent Med. 43:998–1003. 2021.
|
|
16
|
Bhat JA and Kumar M: Neuroprotective
effects of theobromine in permanent bilateral common carotid artery
occlusion rat model of cerebral hypoperfusion. Metab Brain Dis.
37:1787–1801. 2022.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Wu S, Huang R, Zhang R, Xiao C, Wang L,
Luo M, Song N, Zhang J, Yang F, Liu X and Yang W: Gastrodin and
gastrodigenin improve energy metabolism disorders and mitochondrial
dysfunction to antagonize vascular dementia. Molecules.
28(2598)2023.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Shrief AI, Elshenawy DS, Elsukary AE,
Elekhtiar SA and Yahia OA: Behavioral and histological study on the
neuroprotective effect of thymoquinone on the cerebellum in
AlCl3-induced neurotoxicity in rats through modulation of oxidative
stress, apoptosis, and autophagy. J Mol Histol.
56(81)2025.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Schneider MA, Heeb L, Beffinger MM,
Pantelyushin S, Linecker M, Roth L, Lehmann K, Ungethüm U, Kobold
S, Graf R, et al: Attenuation of peripheral serotonin inhibits
tumor growth and enhances immune checkpoint blockade therapy in
murine tumor models. Sci Transl Med. 13(eabc8188)2021.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Yavari N, Nadia Sharifi Z, Rekabdar Y and
Movassaghi S: Protective effect of curcumin on CA1 region of
hippocampus in rat model of ischemia/reperfusion injury. Galen Med
J. 11(e1062)2022.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Yu L, Jin W, Deng D, Wang Y, Chen Q, Zhang
Y, Wan H, Chen Y, Chen Y, He Y and Zhang L: Investigation of
anti-apoptotic effects and mechanisms of Astragaloside IV in a rat
model of cerebral ischemia-reperfusion injury. CNS Neurosci Ther.
31(e70209)2025.PubMed/NCBI View Article : Google Scholar
|
|
22
|
Fan LL, Fang H, Zheng JY, Qiu YH, Wu GL,
Cai YF, Chen YB and Zhang SJ: Taohong Siwu decoction alleviates
cognitive impairment by suppressing endoplasmic reticulum stress
and apoptosis signaling pathway in vascular dementia rats. J
Ethnopharmacol. 333(118407)2024.PubMed/NCBI View Article : Google Scholar
|
|
23
|
Khan MB, Hoda MN, Vaibhav K, Giri S, Wang
P, Waller JL, Ergul A, Dhandapani KM, Fagan SC and Hess DC: Remote
ischemic postconditioning: Harnessing endogenous protection in a
murine model of vascular cognitive impairment. Transl Stroke Res.
6:69–77. 2015.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Li H, Liu Y, Lin LT, Wang XR, Du SQ, Yan
CQ, He T, Yang JW and Liu CZ: Acupuncture reversed hippocampal
mitochondrial dysfunction in vascular dementia rats. Neurochem Int.
92:35–42. 2016.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Ogunro OB, Karigidi ME, Gyebi GA,
Turkistani A and Almehmadi AH: Tangeretin offers neuroprotection
against colchicine-induced memory impairment in Wistar rats by
modulating the antioxidant milieu, inflammatory mediators and
oxidative stress in the brain tissue. BMC Complement Med Ther.
25(40)2025.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Rajabian A, Kioumarsi Darbandi Z, Aliyari
M, Saberi R, Amirahmadi S, Amini H, Salmani H, Youseflee P and
Hosseini M: Pioglitazone improves learning and memory in a rat
model of cholinergic dysfunction induced by scopolamine, the roles
of oxidative stress and neuroinflammation. Naunyn Schmiedebergs
Arch Pharmacol. 398:10221–10237. 2025.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Tian Z, Ji X and Liu J: Neuroinflammation
in vascular cognitive impairment and dementia: Current evidence,
advances, and prospects. Int J Mol Sci. 23(6224)2022.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Yu JY, Fang P, Wang C, Wang XX, Li K, Gong
Q, Luo BY and Wang XD: Dorsal CA1 interneurons contribute to acute
stress-induced spatial memory deficits. Neuropharmacology.
135:474–486. 2018.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Li Y, Ma Y, Dang QY, Fan XR, Han CT, Xu SZ
and Li PY: Assessment of mitochondrial dysfunction and implications
in cardiovascular disorders. Life Sci. 306(120834)2022.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Guo J, Yang N, Zhang J, Huang Y, Xiang Q,
Wen J, Chen Y, Hu T, Liu Q and Rao C: Neurotoxicity study of ethyl
acetate extract of Zanthoxylum armatum DC. on SH-SY5Y based on ROS
mediated mitochondrial apoptosis pathway. J Ethnopharmacol.
319(117321)2024.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Wang S, Yang Y, Lin J, Zhang W, Yang C,
Zhang R, Zhou C, Zhang L, Wang X, Liu J, et al: Astragalin actives
autophagy and inhibits apoptosis of astrocytes in AD mice via
down-regulating Fas/Fasl-VDAC1 pathway. Free Radic Biol Med.
232:72–85. 2025.PubMed/NCBI View Article : Google Scholar
|
|
32
|
Jiao Y and Li G: PARP inhibitor PJ34
ameliorates cognitive impairments induced by transient cerebral
ischemia/reperfusion through its anti-inflammatory effects in a rat
model. Neurosci Lett. 764(136202)2021.PubMed/NCBI View Article : Google Scholar
|
|
33
|
DeFeudis FV and Drieu K: Ginkgo
biloba extract (EGb761) and CNS functions: Basic studies and
clinical applications. Curr Drug Targets. 1:25–58. 2000.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Zhan M, Sun L, Liu J, Zeng Z, Shen W, Li
H, Wang Y, Han F, Shi J, Zeng X, et al: EGb in the treatment for
patients with VCI: A systematic review and meta-analysis. Oxid Med
Cell Longev. 2021(8787684)2021.PubMed/NCBI View Article : Google Scholar
|
|
35
|
Zhu Q and Liu D: Clinical efficacy and
mechanism of Ginkgo biloba extract in the treatment of
elderly ischemic cerebrovascular disease. Pak J Pharm Sci.
37:705–713. 2024.PubMed/NCBI
|
|
36
|
Hua J, Yin N, Yang B, Zhang J, Ding J, Fan
Y and Hu G: Ginkgolide B and bilobalide ameliorate neural cell
apoptosis in α-synuclein aggregates. Biomed Pharmacother.
96:792–797. 2017.PubMed/NCBI View Article : Google Scholar
|
|
37
|
Feng Z, Sun Q, Chen W, Bai Y, Hu D and Xie
X: The neuroprotective mechanisms of ginkgolides and bilobalide in
cerebral ischemic injury: A literature review. Mol Med.
25(57)2019.PubMed/NCBI View Article : Google Scholar
|
|
38
|
Ma S, Yin H, Chen L, Liu H, Zhao M and
Zhang X: Neuroprotective effect of ginkgolide K against acute
ischemic stroke on middle cerebral ischemia occlusion in rats. J
Nat Med. 66:25–31. 2012.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Zhou LJ, Song W, Zhu XZ, Chen ZL, Yin ML
and Cheng XF: Protective effects of bilobalide on amyloid
beta-peptide 25-35-induced PC12 cell cytotoxicity. Acta Pharmacol
Sin. 21:75–79. 2000.PubMed/NCBI
|
|
40
|
Li B, Zhang B, Li Z, Li S, Li J, Wang A,
Hou J, Xu J and Zhang R: Ginkgolide C attenuates cerebral
ischemia/reperfusion-induced inflammatory impairments by
suppressing CD40/NF-κB pathway. J Ethnopharmacol.
312(116537)2023.PubMed/NCBI View Article : Google Scholar
|
|
41
|
Zhou JM, Gu SS, Wang HM, Zhou J, Wang ZZ
and Xiao W: Ginkgolides and bilobalide protect BV2 microglia cells
against OGD/reoxygenation injury by inhibiting TLR2/4 signaling
pathways. Cell Stress Chaperones. 21:1037–1053. 2016.PubMed/NCBI View Article : Google Scholar
|
|
42
|
Mao YJ, Feng YL, Wang MJ, Lyu ZY and Zhai
GY: Research progress on rutin derivatives. Zhongguo Zhong Yao Za
Zhi. 46:4654–4665. 2021.PubMed/NCBI View Article : Google Scholar : (In Chinese).
|
|
43
|
Park DJ, Shah FA and Koh PO: Quercetin
attenuates neuronal cells damage in a middle cerebral artery
occlusion animal model. J Vet Med Sci. 80:676–683. 2018.PubMed/NCBI View Article : Google Scholar
|
|
44
|
He GY, Yuan CG, Hao L, Xu Y and Zhang ZX:
GBE50 attenuates inflammatory response by inhibiting the p38 MAPK
and NF-κB pathways in LPS-stimulated microglial cells. Evid Based
Complement Alternat Med. 2014(368598)2014.PubMed/NCBI View Article : Google Scholar
|
|
45
|
Skaper SD: Poly(ADP-ribosyl)ation enzyme-1
as a target for neuroprotection in acute central nervous system
injury. Curr Drug Targets CNS Neurol Disord. 2:279–291.
2003.PubMed/NCBI View Article : Google Scholar
|