Role of RGD-containing ligands in targeting cellular integrins: Applications for ovarian cancer virotherapy (Review)

  • Authors:
    • Lena J. Gamble
    • Anton V. Borovjagin
    • Qiana L. Matthews
  • View Affiliations

  • Published online on: March 1, 2010     https://doi.org/10.3892/etm_00000037
  • Pages: 233-240
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Abstract

The purpose of this article was to review the current strategies of targeted therapy to integrins and define the best course of future research in ovarian cancer targeting. Cell surface integrin targeting has been used as a strategy for targeted therapy of several diseases with some success. The combination of virotherapy and integrin-targeting shows promise as a method for targeting ovarian cancer. More specifically, targeting of ovarian cancer with integrin-directed adenoviruses may lead to therapy with fewer toxicities and side effects. This article offers a review of the benefits of integrin-specific targeted therapy for several diseases and proposes a unique anti-ovarian cancer strategy involving the combination of the above with virotherapy as a potential anti-ovarian cancer treatment.
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March-April 2010
Volume 1 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Gamble LJ, Borovjagin AV and Matthews QL: Role of RGD-containing ligands in targeting cellular integrins: Applications for ovarian cancer virotherapy (Review) . Exp Ther Med 1: 233-240, 2010.
APA
Gamble, L.J., Borovjagin, A.V., & Matthews, Q.L. (2010). Role of RGD-containing ligands in targeting cellular integrins: Applications for ovarian cancer virotherapy (Review) . Experimental and Therapeutic Medicine, 1, 233-240. https://doi.org/10.3892/etm_00000037
MLA
Gamble, L. J., Borovjagin, A. V., Matthews, Q. L."Role of RGD-containing ligands in targeting cellular integrins: Applications for ovarian cancer virotherapy (Review) ". Experimental and Therapeutic Medicine 1.2 (2010): 233-240.
Chicago
Gamble, L. J., Borovjagin, A. V., Matthews, Q. L."Role of RGD-containing ligands in targeting cellular integrins: Applications for ovarian cancer virotherapy (Review) ". Experimental and Therapeutic Medicine 1, no. 2 (2010): 233-240. https://doi.org/10.3892/etm_00000037