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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
March-April 2010 Volume 1 Issue 2

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Impact Factor: 2.3

Article

Combinatorial intervention of prostaglandin E2 receptor and calcium sensing receptor to attenuate breast cancer cell proliferation, migration and bone metastasis (Review)

Jai Parkash, Kamlesh Asotra
Pages: 227-231
Published online on: 01 March 2010

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Article

Role of RGD-containing ligands in targeting cellular integrins: Applications for ovarian cancer virotherapy (Review)

Lena J. Gamble, Anton V. Borovjagin, Qiana L. Matthews
Pages: 233-240
Published online on: 01 March 2010

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Article

Dietary factors, genetic and epigenetic influences in colorectal cancer (Review)

M. L. Pellegrini, P. Argibay, D. E. Gomez
Pages: 241-250
Published online on: 01 March 2010

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Article

Novel strategy with acidic arginine solution for the treatment of influenza A virus infection (Review)

Keiko Ikeda, Hisashi Yamasaki, Yukiko Suzuki, A. Hajime Koyama, Tsutomu Arakawa
Pages: 251-256
Published online on: 01 March 2010

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Article

The use of Cox-2 and PPARγ signaling in anti-cancer therapies (Review)

Lucia Knopfová, Jan Šmarda
Pages: 257-264
Published online on: 01 March 2010

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Article Open Access

Curcumin for the prevention of progression in monoclonal gammopathy of undetermined significance: A word of caution (Review)

A. J.M. Vermorken, J. Zhu, W. J.M. van de Ven, Y. Cui, J. P. Fryns
Pages: 265-269
Published online on: 01 March 2010

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Article

EML4-ALK fusion transcripts in immunohistochemically ALK-positive non-small cell lung carcinomas

Kazuya Shinmura, Shinji Kageyama, Hisaki Igarashi, Takaharu Kamo, Takahiro Mochizuki, Kazuya Suzuki, Masayuki Tanahashi, Hiroshi Niwa, Hiroshi Ogawa, Haruhiko Sugimura
Pages: 271-275
Published online on: 01 March 2010

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Article

Deuterium-depleted water inhibits human lung carcinoma cell growth by apoptosis

Feng-Song Cong, Ya-Ru Zhang, Hong-Cai Sheng, Zong-Hua Ao, Su-Yi Zhang, Ju-Yong Wang
Pages: 277-283
Published online on: 01 March 2010

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Article

Macrophage involvement in Epstein-Barr virus-related tumors

Misuzu Shimakage, Haruhiko Sakamoto
Pages: 285-291
Published online on: 01 March 2010

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Article

Evaluation of the microvascular density in astrocytomas in adults correlated using SPECT-MIBI

Sandro Pantoja Cavalcante, José R.W. De Almeida, Carlos A. Clara, Cristovam Scapulatempo Neto, Stela Verzinhase Peres, Sônia M. Moriguchi, Marcelo J. Dos Santos, Euclides T. Da Rocha
Pages: 293-299
Published online on: 01 March 2010

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Article

Telmisartan inhibits human urological cancer cell growth through early apoptosis

Masahide Matsuyama, Kiyoaki Funao, Katsuyuki Kuratsukuri, Tomoaki Tanaka, Yutaka Kawahito, Hajime Sano, Jamel Chargui, Jean-Louis Touraine, Norio Yoshimura, Rikio Yoshimura
Pages: 301-306
Published online on: 01 March 2010

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Article

Electrolyte and protein imbalance following anti-EGFR therapy in cancer patients: A comparative study

Pius Maliakal, Andrea Ledford
Pages: 307-311
Published online on: 01 March 2010

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Article

Soluble mesothelin-related protein in pleural effusion from patients with malignant pleural mesothelioma

Nobukazu Fujimoto, Kenichi Gemba, Michiko Asano, Sae Wada, Katsuichiro Ono, Shinji Ozaki, Takumi Kishimoto
Pages: 313-317
Published online on: 01 March 2010

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Article Open Access

Combination of chemotherapy and mild hyperthermia enhances the anti-tumor effects of cisplatin and adriamycin in human bladder cancer T24 cells in vitro

Youko Itoh, Yoshiaki Yamada, Yoshiaki Kazaoka, Tsuneo Ishiguchi, Nobuaki Honda
Pages: 319-323
Published online on: 01 March 2010

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Article

Leucovorin and fluorouracil plus oxaliplatin or leucovorin and fluorouracil plus irinotecan as individualized first-line therapy based on a drug sensitivity test

Takumi Ochiai, Kazuhiko Nishimura, Tomoo Watanabe, Masayuki Kitajima, Tadasuke Hashiguchi, Akinori Nakatani, Takashi Marusasa, Akira Muraki, Isao Nagaoka, Shunji Futagawa
Pages: 325-329
Published online on: 01 March 2010

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Article

Gene expression and effects of orally active derivatives of fluoropyrimidine on gastric and colorectal cancer

Satoshi Arakawa, Soji Ozawa, Jin Kawase, Hisanori Oshima, Hidetoshi Nagata, Koji Atsuta, Shunji Umemoto
Pages: 331-336
Published online on: 01 March 2010

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Article

Effect of fibroblast growth factor-2 on periodontal ligament cells derived from human deciduous teeth in vitro

Tomokazu Hasegawa, Naoyuki Chosa, Takeyoshi Asakawa, Yoshitaka Yoshimura, Asami Asakawa, Akira Ishisaki, Mitsuro Tanaka
Pages: 337-341
Published online on: 01 March 2010

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Article

Clinical significance of hepatitis B virus-DNA in hepatocellular carcinoma negative for hepatitis B virus surface antigen

Shinpei Tateiwa, Yoshihiko Yano, Yasushi Seo, Akira Miki, Kawano Yuuki, Takeshi Azuma, Yoshitake Hayashi
Pages: 343-346
Published online on: 01 March 2010

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Article

Expression of epithelial-mesenchymal transition markers in locally recurrent hepatocellular carcinoma after radiofrequency ablation

Hidehiro Tajima, Tetsuo Ohta, Isamu Makino, Hironori Hayashi, Hisatoshi Nakagawara, Ichiro Onishi, Hiroyuki Takamura, Itasu Ninomiya, Hirohisa Kitagawa, Sachio Fushida, Takashi Tani, Takashi Fujimura, Masato Kayahara, Kuniaki Arai, Tatsuya Yamashita, Shuichi Kaneko, Yoh Zen
Pages: 347-350
Published online on: 01 March 2010

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Article

Role of inhibitor of DNA binding-1 protein is related to angiogenesis in the tumor advancement of uterine endometrial cancers

Min K. Maw, Jiro Fujimoto, Teruhiko Tamaya
Pages: 351-356
Published online on: 01 March 2010

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Article

Serological levels of mutated p53 protein are highly detected at early stages in breast cancer patients

Gabriela A. Balogh, Daniel Mailo, Hector Nardi, Maria M. Corte, Esteban Vincent, Elena Barutta, Guillermo Lizarraga, Pablo Lizarraga, Hector Montero, Roberto Gentili
Pages: 357-361
Published online on: 01 March 2010

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Article

Adenovirus Ad-p53AIP1-mediated gene therapy and its regulation of p53-MDM2 interactions

Yunbo Jiang, Huihua Chen, Haiquan Jia, Yuanji Xu, Gang Liu, Yan Wang, Xiaohe Yang, Yinglin Lu
Pages: 363-368
Published online on: 01 March 2010

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Article

Thymoquinone hydrazone derivatives cause cell cycle arrest in p53-competent colorectal cancer cells

André Wirries, Sandra Breyer, Karl Quint, Rainer Schobert, Matthias Ocker
Pages: 369-375
Published online on: 01 March 2010

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Article

Association of a polymorphism of ROR2 and ischemic stroke in Japanese individuals with chronic kidney disease

Mitsutoshi Oguri, Takanori Nagahiro, Haruo Kamiya, Miyoshi Ohno, Kimihiko Kato, Kiyoshi Yokoi, Tetsuro Yoshida, Sachiro Watanabe, Norifumi Metoki, Hidemi Yoshida, Kei Satoh, Yukitoshi Aoyagi, Yoshinori Nozawa, Yoshiji Yamada
Pages: 377-384
Published online on: 01 March 2010

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Article

Genetic and epigenetic alterations of RIZ1 and the correlation to clinicopathological parameters in liver fluke-related cholangiocarcinoma

Prasong Khaenam, Patcharee Jearanaikoon, Chawalit Pairojkul, Vajarabhongsa Bhudhisawasdi, Temduang Limpaiboon
Pages: 385-390
Published online on: 01 March 2010

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Article

Role of immunohistochemistry and apoptosis as investigative tools in assessing the prognosis of patients with prostate tumours

Srikumar Chakravarthi, P. M. Thani, David L.W. Yang, Linda T. Husin, Nagaraja Lee
Pages: 391-393
Published online on: 01 March 2010

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Article

Expression and tissue distribution of human X-linked armadillo repeat containing-6

Yusuke Kusama, Sayuri Takayanagi, Moe Tategu, Kenichi Yoshida
Pages: 395-399
Published online on: 01 March 2010

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Journal Cover
April-2026 Volume 31 Issue 4

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Impact Factor: 2.3

Article Open Access

DKK1/SMDT1 participate in Ang II‑induced mitochondrial injury of human smooth muscle cells in an abdominal aortic aneurysm cell model

Xiaoxia Chang, Baohong Yao, Zheng Liu, Zijie Guo, Pengyue Qiao, Xiaokun Li, Lin Wang, Aiqun Li
Article Number: 117
Published online on: 25 February 2026

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Retraction Open Access

[Retracted] Vascular endothelial growth factor participates in modulating the C6 glioma‑induced migration of rat bone marrow‑derived mesenchymal stem cells and upregulates their vascular cell adhesion molecule‑1 expression

Zhiqiang Gao, Peng Cheng, Yixue Xue, Yunhui Liu
Article Number: 116
Published online on: 24 February 2026

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Case Report Open Access

Rhabdomyolysis in a patient with lung cancer with sintilimab‑induced overlap syndrome and hypothyroidism: A case report

Bingyi Chen, Yi Liu, Qin Zeng, Shitong Yan, Xiujuan Liu, Quanlin Zhao
Article Number: 115
Published online on: 17 February 2026

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Case Report Open Access

Secondary pulmonary lymphoma diagnosed by minimal residual disease detected in bronchoalveolar lavage fluid: A case report

Yingying Hu, Zheng Lv, Lehao Ren, Xin Zhao, Hong Liu, Yin Yuan
Article Number: 114
Published online on: 17 February 2026

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Review Open Access

Gut microbiota‑metabolism axis in digestive tumors: Emerging targets for novel therapies (Review)

Zhendong Yang, Siyu Wu, Xueying Yang, Bowen Sui
Article Number: 113
Published online on: 17 February 2026

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Retraction Open Access

[Retracted] Sanmiao formula inhibits chondrocyte apoptosis and cartilage matrix degradation in a rat model of osteoarthritis

Ying Xu, Guo-Jing Dai, Qian Liu, Zhen-Li Liu, Zhi-Qian Song, Li Li, Wei-Heng Chen, Na Lin
Article Number: 112
Published online on: 16 February 2026

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Article Open Access

Metformin triggers apoptosis via endoplasmic reticulum stress in HER2‑positive breast cancer cell lines

Eser Çakmak, Bi̇rşen Bi̇lgi̇ci̇
Article Number: 111
Published online on: 13 February 2026

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Article Open Access

Identification of a novel PLS1 heterozygous variant causing autosomal dominant non‑syndromic hearing loss

Chenxi Yang, Yao Xiong, Dongyang Wang, Juanzi Shi
Article Number: 110
Published online on: 12 February 2026

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Case Report

Familial SCA14: A case report with review

Han-Ke Huang, Chia-Ju Lee, Wen-Ling Cheng, Hui-Ju Chang, Chin-San Liu
Article Number: 109
Published online on: 12 February 2026

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Article Open Access

Efficacy of opioids in combination with gabapentin vs. opioids alone in the treatment of patients with cancer‑related pain due to bone metastases from malignant neoplasms: A meta‑analysis

Hongli Zhou, Jun Feng, Zuolei Tang
Article Number: 108
Published online on: 12 February 2026

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Article Open Access

Drug‑related problems in pediatric patients with chronic kidney disease: A single‑center prospective study

Xingxing Liu, Yue Li, Zhen Mao, Xin Wang, Shan Zhao, Qiu Han, Jia Liu, Yan Zhou, Shi Li, Bing Chen, Yongfu Hang, Wan Yan, Xiaoye Jin
Article Number: 107
Published online on: 12 February 2026

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Article Open Access

Effects of the WNT signaling pathway on inflammation and fibrosis in idiopathic pulmonary fibrosis: Clinical, radiological and molecular evaluation

İlknur Kaya, Ayşe Koçak Sezgi̇n, Meliha Koldemi̇r Gündüz, Şebnem Emine Parspur, Feride Marim, Mehmet Doğan, Ümran Toru Erbay
Article Number: 106
Published online on: 11 February 2026

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Article

IGFBP1 as a metabolic‑neurodegenerative biomarker in spinocerebellar ataxia type 3

Chungmin Chiu, Wenling Cheng, Tatsung Lin, Huiju Chang, Yujun Chang, Shihli Su, Chiaju Lee, Henhong Chang, Chinsan Liu
Article Number: 105
Published online on: 10 February 2026

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Case Report Open Access

Endodontic re‑treatment of the mandibular first molar with six root canals: A case report

Chen Wang, Mengyu Liu
Article Number: 104
Published online on: 09 February 2026

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Retraction Open Access

[Retracted] Effect of enhanced expression of COL8A1 on lymphatic metastasis of hepatocellular carcinoma in mice

Zhen-Hai Ma, Jin-Hui Ma, Li Jia, Yong-Fu Zhao
Article Number: 103
Published online on: 09 February 2026

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Article Open Access

Surgical treatment of extrahepatic intraabdominal hydatid cysts: A single‑centre retrospective analysis

Fatih Dal, Tutkun Talih, Muhammet Akyüz, Uğur Topal, Gökhan Sönmez, Erdoğan Mütevelli Sözüer, Hizir Yakup Akyildiz, Mustafa Karaağaç, Sedat Çarkit, Doğan Gürkan İslam
Article Number: 102
Published online on: 09 February 2026

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Article Open Access

Analysis of independent prognostic factors for the occurrence and severity of heart failure after chemotherapy in patients with small cell lung cancer 

Jieqiong Zhao, Xiao Wang, Xiaoxue Liu, Wei Zhao, Xia Lu, Ruijie Li, Xiang Sun
Article Number: 101
Published online on: 09 February 2026

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Case Report

Sagittal sinus thrombosis in pregnancy: A case report

Zaheera Saadia, Misbah Ilyas, Jayd Saud Althwiny, Fai Alaqel, Alanoud Abdullah Alsufayri, Lujain Husain Almutairi
Article Number: 100
Published online on: 05 February 2026

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Article

Elevated PGE2 and COX‑2 expression in villous adenoma: Implications for electrolyte depletion syndrome

Shiki Fujino, Hiroyuki Fukuda, Katsuki Danno, Takashi Takeda, Masaya Higashiguchi, Kozo Noguchi, Takefumi Hirao, Aya Ito, Norikatsu Miyoshi, Yoshio Oka
Article Number: 99
Published online on: 04 February 2026

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Article Open Access

Wogonin as a potential therapeutic agent for psoriasis: Core target identification and validation

Yu Lu, Xiaomei Zhou, Yiyu Guo, Fengrui Zhang, Jirong Wang, Jinhong Ge, Yan Xiao, Dengke Yang
Article Number: 98
Published online on: 04 February 2026

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Expression of Concern Open Access

[Expression of Concern] Glibenclamide exacerbates adriamycin‑induced cardiotoxicity by activating oxidative stress‑induced endoplasmic reticulum stress in rats

Meng-Lin Liu, Meng-Long Wang, Jing-Jun Lv, Jie Wei, Jun Wan
Article Number: 97
Published online on: 04 February 2026

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Review

Key role of the autonomic nervous system in breast cancer (Review)

Min Wu, Zhiwu Zhang, Lu Zhou, Shiqi Liu, Qing Chen, Cui Guo, Shasha Zhao, Xuedan Chen
Article Number: 96
Published online on: 04 February 2026

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Review Open Access

Senescent hepatic stellate cells drive inflammation and disease progression in MASH (Review)

Zhiqi Han, Yiran She, Di Wu, Nuo Zhang, Zheyuan Liu, Zhongyuan Wang, Xiaoying Zhou, Shuo Li
Article Number: 95
Published online on: 04 February 2026

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Article Open Access

PUM2 knockdown regulates the expression and alternative splicing of genes associated with myocardial fibrosis in H9C2 cells

Zilong Zhang, Hangyu Zhou, Diliyaer Adili, Wei Zhu, Yong Liu, Wenzheng Zhou, Zhao Wang, Jie Li
Article Number: 94
Published online on: 04 February 2026

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Case Report

A novel human papillomavirus‑induced ‘doughnut wart’ lesion treated with 5‑aminolevulinic acid photodynamic therapy: A case report

Ke Li, Yitao Qian, Wenjing Zha, Lei Shi
Article Number: 93
Published online on: 04 February 2026

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Case Report Open Access

Comprehensive diagnosis and individualized treatment of multiple primary lung cancer: A case report

Guoxiong Zeng, Yunyan Zhou, Wang Wan, Biao Deng, Chunyuan Chen, Zhu Liang
Article Number: 92
Published online on: 03 February 2026

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Review Open Access

Pathophysiological mechanisms of fatigue and multidisciplinary management strategies (Review)

Hong Zhou, Wenwen Yu, Jiaming Lei, Runzhi Chang, Yingjia Cheng, Guorui Wang, Li Lin
Article Number: 91
Published online on: 03 February 2026

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Case Report Open Access

A rare upstream regulatory region mutation in APC presenting as classical familial adenomatous polyposis: A case report and literature review

Chi-Han Yang, Yen-Cheng Chen, Tsung-Kun Chang, Wei-Chih Su, Ching-Wen Huang, Hsiang-Lin Tsai, Jaw-Yuan Wang
Article Number: 90
Published online on: 02 February 2026

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Retraction Open Access

[Retracted] lncRNA MIAT promote cell invasion and migration in esophageal cancer

Weiguo Zhang, Qiang Chen, Caipeng Lei
Article Number: 89
Published online on: 02 February 2026

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Review Open Access

Mitochondria‑driven ferroptosis in intervertebral disc degeneration: A novel target in age‑related spinal diseases (Review)

Yang Hou, Xiaolei Yang, Duorun Qiu, Lei Liu, Jiangang Shi, Yongfei Guo
Article Number: 88
Published online on: 02 February 2026

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Case Report

Preoperative treatment with thyroid artery embolization in a patient with a giant retrosternal goiter causing severe tracheal compression: A case report

Jingxian Li, Fang Wang, Yuanshu Du, Yonghui Wang
Article Number: 87
Published online on: 02 February 2026

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Case Report Open Access

Gastric wall thickening and gastric outlet obstruction due to peritoneal metastasis in breast cancer: A case report

Bin He, Lin Ling Li, Ting Yu, Yu Tan, Ling Zhang
Article Number: 86
Published online on: 29 January 2026

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Article Open Access

Myrrh ameliorates endometriosis by enhancing ER stress‑related apoptotic cell death

Bo-Sung Kim, Minkyoung Cho, Jung Ho Han, Jung-Sook Jin, Sung-Jin Bae, Yunju Jo, Dongryeol Ryu, Yerim Joo, Seon Beom Kim, Jongkil Joo, Inhye Kim, Ki-Tae Ha
Article Number: 85
Published online on: 29 January 2026

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Journal Cover
May-2026 Volume 31 Issue 5

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Impact Factor: 2.3

Article

Effects of spironolactone on cytotoxic damage in osteoblasts

So Young Park, Kwang Sik Suh, Hyun-Sook Kim, Soo Jin Yun, Hyunji Sang, Sang Ouk Chin
Article Number: 122
Published online on: 27 February 2026

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Article Open Access

RNU2‑1 gene copy number variations do not affect serum levels of miR‑1246 as a biomarker for lung adenocarcinoma

Makiko Ueda, Shinya Sato, Yohei Miyagi, Toshiko Aiso
Article Number: 121
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