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Experimental and Therapeutic Medicine
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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
March-April 2010 Volume 1 Issue 2

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Impact Factor: 2.3

Article

Combinatorial intervention of prostaglandin E2 receptor and calcium sensing receptor to attenuate breast cancer cell proliferation, migration and bone metastasis (Review)

Jai Parkash, Kamlesh Asotra
Pages: 227-231
Published online on: 01 March 2010

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Article

Role of RGD-containing ligands in targeting cellular integrins: Applications for ovarian cancer virotherapy (Review)

Lena J. Gamble, Anton V. Borovjagin, Qiana L. Matthews
Pages: 233-240
Published online on: 01 March 2010

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Article

Dietary factors, genetic and epigenetic influences in colorectal cancer (Review)

M. L. Pellegrini, P. Argibay, D. E. Gomez
Pages: 241-250
Published online on: 01 March 2010

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Article

Novel strategy with acidic arginine solution for the treatment of influenza A virus infection (Review)

Keiko Ikeda, Hisashi Yamasaki, Yukiko Suzuki, A. Hajime Koyama, Tsutomu Arakawa
Pages: 251-256
Published online on: 01 March 2010

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Article

The use of Cox-2 and PPARγ signaling in anti-cancer therapies (Review)

Lucia Knopfová, Jan Šmarda
Pages: 257-264
Published online on: 01 March 2010

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Article Open Access

Curcumin for the prevention of progression in monoclonal gammopathy of undetermined significance: A word of caution (Review)

A. J.M. Vermorken, J. Zhu, W. J.M. van de Ven, Y. Cui, J. P. Fryns
Pages: 265-269
Published online on: 01 March 2010

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Article

EML4-ALK fusion transcripts in immunohistochemically ALK-positive non-small cell lung carcinomas

Kazuya Shinmura, Shinji Kageyama, Hisaki Igarashi, Takaharu Kamo, Takahiro Mochizuki, Kazuya Suzuki, Masayuki Tanahashi, Hiroshi Niwa, Hiroshi Ogawa, Haruhiko Sugimura
Pages: 271-275
Published online on: 01 March 2010

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Article

Deuterium-depleted water inhibits human lung carcinoma cell growth by apoptosis

Feng-Song Cong, Ya-Ru Zhang, Hong-Cai Sheng, Zong-Hua Ao, Su-Yi Zhang, Ju-Yong Wang
Pages: 277-283
Published online on: 01 March 2010

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Article

Macrophage involvement in Epstein-Barr virus-related tumors

Misuzu Shimakage, Haruhiko Sakamoto
Pages: 285-291
Published online on: 01 March 2010

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Article

Evaluation of the microvascular density in astrocytomas in adults correlated using SPECT-MIBI

Sandro Pantoja Cavalcante, José R.W. De Almeida, Carlos A. Clara, Cristovam Scapulatempo Neto, Stela Verzinhase Peres, Sônia M. Moriguchi, Marcelo J. Dos Santos, Euclides T. Da Rocha
Pages: 293-299
Published online on: 01 March 2010

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Article

Telmisartan inhibits human urological cancer cell growth through early apoptosis

Masahide Matsuyama, Kiyoaki Funao, Katsuyuki Kuratsukuri, Tomoaki Tanaka, Yutaka Kawahito, Hajime Sano, Jamel Chargui, Jean-Louis Touraine, Norio Yoshimura, Rikio Yoshimura
Pages: 301-306
Published online on: 01 March 2010

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Article

Electrolyte and protein imbalance following anti-EGFR therapy in cancer patients: A comparative study

Pius Maliakal, Andrea Ledford
Pages: 307-311
Published online on: 01 March 2010

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Article

Soluble mesothelin-related protein in pleural effusion from patients with malignant pleural mesothelioma

Nobukazu Fujimoto, Kenichi Gemba, Michiko Asano, Sae Wada, Katsuichiro Ono, Shinji Ozaki, Takumi Kishimoto
Pages: 313-317
Published online on: 01 March 2010

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Article Open Access

Combination of chemotherapy and mild hyperthermia enhances the anti-tumor effects of cisplatin and adriamycin in human bladder cancer T24 cells in vitro

Youko Itoh, Yoshiaki Yamada, Yoshiaki Kazaoka, Tsuneo Ishiguchi, Nobuaki Honda
Pages: 319-323
Published online on: 01 March 2010

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Article

Leucovorin and fluorouracil plus oxaliplatin or leucovorin and fluorouracil plus irinotecan as individualized first-line therapy based on a drug sensitivity test

Takumi Ochiai, Kazuhiko Nishimura, Tomoo Watanabe, Masayuki Kitajima, Tadasuke Hashiguchi, Akinori Nakatani, Takashi Marusasa, Akira Muraki, Isao Nagaoka, Shunji Futagawa
Pages: 325-329
Published online on: 01 March 2010

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Article

Gene expression and effects of orally active derivatives of fluoropyrimidine on gastric and colorectal cancer

Satoshi Arakawa, Soji Ozawa, Jin Kawase, Hisanori Oshima, Hidetoshi Nagata, Koji Atsuta, Shunji Umemoto
Pages: 331-336
Published online on: 01 March 2010

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Article

Effect of fibroblast growth factor-2 on periodontal ligament cells derived from human deciduous teeth in vitro

Tomokazu Hasegawa, Naoyuki Chosa, Takeyoshi Asakawa, Yoshitaka Yoshimura, Asami Asakawa, Akira Ishisaki, Mitsuro Tanaka
Pages: 337-341
Published online on: 01 March 2010

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Article

Clinical significance of hepatitis B virus-DNA in hepatocellular carcinoma negative for hepatitis B virus surface antigen

Shinpei Tateiwa, Yoshihiko Yano, Yasushi Seo, Akira Miki, Kawano Yuuki, Takeshi Azuma, Yoshitake Hayashi
Pages: 343-346
Published online on: 01 March 2010

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Article

Expression of epithelial-mesenchymal transition markers in locally recurrent hepatocellular carcinoma after radiofrequency ablation

Hidehiro Tajima, Tetsuo Ohta, Isamu Makino, Hironori Hayashi, Hisatoshi Nakagawara, Ichiro Onishi, Hiroyuki Takamura, Itasu Ninomiya, Hirohisa Kitagawa, Sachio Fushida, Takashi Tani, Takashi Fujimura, Masato Kayahara, Kuniaki Arai, Tatsuya Yamashita, Shuichi Kaneko, Yoh Zen
Pages: 347-350
Published online on: 01 March 2010

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Article

Role of inhibitor of DNA binding-1 protein is related to angiogenesis in the tumor advancement of uterine endometrial cancers

Min K. Maw, Jiro Fujimoto, Teruhiko Tamaya
Pages: 351-356
Published online on: 01 March 2010

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Article

Serological levels of mutated p53 protein are highly detected at early stages in breast cancer patients

Gabriela A. Balogh, Daniel Mailo, Hector Nardi, Maria M. Corte, Esteban Vincent, Elena Barutta, Guillermo Lizarraga, Pablo Lizarraga, Hector Montero, Roberto Gentili
Pages: 357-361
Published online on: 01 March 2010

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Article

Adenovirus Ad-p53AIP1-mediated gene therapy and its regulation of p53-MDM2 interactions

Yunbo Jiang, Huihua Chen, Haiquan Jia, Yuanji Xu, Gang Liu, Yan Wang, Xiaohe Yang, Yinglin Lu
Pages: 363-368
Published online on: 01 March 2010

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Article

Thymoquinone hydrazone derivatives cause cell cycle arrest in p53-competent colorectal cancer cells

André Wirries, Sandra Breyer, Karl Quint, Rainer Schobert, Matthias Ocker
Pages: 369-375
Published online on: 01 March 2010

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Article

Association of a polymorphism of ROR2 and ischemic stroke in Japanese individuals with chronic kidney disease

Mitsutoshi Oguri, Takanori Nagahiro, Haruo Kamiya, Miyoshi Ohno, Kimihiko Kato, Kiyoshi Yokoi, Tetsuro Yoshida, Sachiro Watanabe, Norifumi Metoki, Hidemi Yoshida, Kei Satoh, Yukitoshi Aoyagi, Yoshinori Nozawa, Yoshiji Yamada
Pages: 377-384
Published online on: 01 March 2010

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Article

Genetic and epigenetic alterations of RIZ1 and the correlation to clinicopathological parameters in liver fluke-related cholangiocarcinoma

Prasong Khaenam, Patcharee Jearanaikoon, Chawalit Pairojkul, Vajarabhongsa Bhudhisawasdi, Temduang Limpaiboon
Pages: 385-390
Published online on: 01 March 2010

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Article

Role of immunohistochemistry and apoptosis as investigative tools in assessing the prognosis of patients with prostate tumours

Srikumar Chakravarthi, P. M. Thani, David L.W. Yang, Linda T. Husin, Nagaraja Lee
Pages: 391-393
Published online on: 01 March 2010

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Article

Expression and tissue distribution of human X-linked armadillo repeat containing-6

Yusuke Kusama, Sayuri Takayanagi, Moe Tategu, Kenichi Yoshida
Pages: 395-399
Published online on: 01 March 2010

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Journal Cover
May-2026 Volume 31 Issue 5

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Impact Factor: 2.3

Review Open Access

FCER1G: A multifunctional regulator in the immune microenvironment (Review)

Yuyu Zhang, Jinglan Wang, Wenting He, Tao Liu
Article Number: 146
Published online on: 26 March 2026

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Article Open Access

A nomogram for predicting recurrence‑free survival in patients with high‑risk GIST receiving adjuvant imatinib: A nationwide registry study

Chun-Nan Yeh, Yan-Shen Shan, Ching-Yao Yang, Chin-Fu Hsiao, Chung-Hsin Tsai, Chuan-Cheng Wang, Ming-Tsan Lin, Chun-Fu Ting, De-Chuan Chan, Te-Hung Chen, Chueh-Chuan Yen, Yen-Yang Chen, Hsuan-Yu Lin, Ta-Sen Yeh, Ching-Liang Ho, Tze-Yu Shieh, Li-Yaun Bai, Jun-Te Hsu, I-Shu Chen, Li-Tzong Chen, Hui-Jen Tsai, The Taiwan Cooperative Oncology Group Gist Study Group
Article Number: 145
Published online on: 24 March 2026

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Retraction Open Access

[Retracted] MicroRNA‑18a‑5p represses scar fibroblast proliferation and extracellular matrix deposition through regulating Smad2 expression

Tianshi Li, Yiguang Wu, Dandan Liu, Lida Zhuang
Article Number: 144
Published online on: 23 March 2026

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Article

Risk factors for severe retinopathy of prematurity: A retrospective case‑control study

Qingmin Ma, Xi Lv, Jiangya Wang, Kejun Li, Wenwen Τang
Article Number: 143
Published online on: 20 March 2026

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Article Open Access

Atorvastatin augments collateral formation and functional recovery after indirect revascularization in adult ischemic moyamoya disease: A randomized trial

Dawei Wang, Jingya Dai, Shumei Li, Yaping Liu, Xiaofeng Xing, Lei Huang, Qijun Pang
Article Number: 142
Published online on: 19 March 2026

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Article Open Access

Maresin 1 activates autophagy through SIRT1/PPAR‑γ signaling to mitigate high glucose‑induced pyroptosis in human retinal pigment epithelial cells

Jun Zhang, Ding Zhao, Yuanqing Zhang, Haoxiang Sun, Zhipeng Yan, Haiyan Sun
Article Number: 141
Published online on: 19 March 2026

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Review Open Access

Advances in new ultrasound technologies in targeted prostate biopsy (Review)

Tingting Jin, Liying Wang, Shusen Zheng
Article Number: 140
Published online on: 19 March 2026

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Review Open Access

Immune cross talk and therapeutic advances in lactate metabolism in the tumor microenvironment (Review)

Min Liu, Kui Su
Article Number: 139
Published online on: 19 March 2026

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Article Open Access

Immunohistochemical evaluation of gastric‑type markers in primary extramammary Paget disease: Differential MUC5AC expression between in situ and invasive lesions

Naoto Kohno, Mitsuaki Ishida, Shizuka Ono, Yoshinobu Hirose
Article Number: 138
Published online on: 19 March 2026

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Review Open Access

Disrupted beginnings: Neurodevelopmental outcomes of COVID‑19 lockdowns in early childhood (Review)

Ioanna Giannopoulou, Vasiliki Efstathiou, Maria-Ioanna Stefanou, Panagiota Korkoliakou, James N. Tsoporis, Demetrios A. Spandidos, Emmanouil Rizos
Article Number: 137
Published online on: 16 March 2026

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Retraction Open Access

[Retracted] Icariin inhibits oral squamous cell carcinoma cell proliferation and induces apoptosis via inhibiting the NF‑κB and PI3K/AKT pathways

Ling Sun, Jing Zhang
Article Number: 136
Published online on: 16 March 2026

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Article Open Access

Effects of fullerenol C60 on the liver, heart and brain tissues of streptozotocin‑induced diabetic rats with sepsis

Necmiye Şengel, Ömer Kubat, Laman Farajsoylu, Ahmet Çağri Büyükkasap, Muharrem Atli, Şaban Cem Sezen, Hasan Bostanci, Kürşat Dikmen, Işin Güneş, Fatma Er, Mustafa Kavutçu, Mustafa Arslan
Article Number: 135
Published online on: 13 March 2026

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Article Open Access

Long non‑coding RNA KCNQ1OT1 promotes ovarian cancer cell malignant characteristics by targeting the miR‑140‑5p/KLK10 axis

Renjie Duan, Zhenyu Tao, Shun Tao, Aichen Yang, Xu Yang, Changzheng Li, Xiaoxiang Zhu, Kexin Zhang, Zhuofu Li, Shanjun Tao
Article Number: 134
Published online on: 11 March 2026

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Article

Deciphering the dynamics of the splenium: A comprehensive analysis of flair hyperintensity variations

Ezel Yaltirik Bilgin, Özkan Ünal, Yasin Özdemir, Onur Şimşek
Article Number: 133
Published online on: 09 March 2026

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Article Open Access

Prior curative‑intent treatment strategy affects progression outcomes of first‑line immunotherapy in metastatic non‑small cell lung cancer: A retrospective cohort study

Ruhper Cekin, Didar Senocak, Serdar Arici, Alpaslan Ozgun
Article Number: 132
Published online on: 09 March 2026

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Retraction Open Access

[Retracted] Recent perspectives of electronic medical record systems (Review)

Xiao-Ying Zhang, Peiying Zhang
Article Number: 131
Published online on: 09 March 2026

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Case Report Open Access

Direct venous‑to‑arterial communication as a novel mechanism for ectopic embolism following esophageal variceal embolization: A case report

Youchun Lei, You Ke, Tianwen Yang, Zhengguo Xu
Article Number: 130
Published online on: 06 March 2026

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Case Report

Diagnostic and therapeutic challenges of isolated spinal vasculitis: A case report

Yajun Yao, Ge-Hong Dong, De-Cai Tian
Article Number: 129
Published online on: 06 March 2026

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Article Open Access

Impact of older age on prognosis in hypersensitivity pneumonitis: A systematic review and meta‑analysis

Konstantinos Dodos, Tsampika-Vasileia Kalamara, Vasiliki Therapioti‑Mavroudi, Nikolaos Trakas, Eleni Sklapani, Demetrios A. Spandidos, Alexandru Corlateanu, Vasiliki Epameinondas Georgakopoulou
Article Number: 128
Published online on: 06 March 2026

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Article

Anti‑inflammatory effects of oridonin on an in vitro model using LPS‑treated human intestinal Caco‑2 cells

Maonan Wang, Bo Xu, Linyue Li, Yu Wang, Mingcheng Li
Article Number: 127
Published online on: 03 March 2026

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Case Report

Management after two consecutive suction losses during small‑incision lenticule extraction: A case report

Luanying Wei, Tiantian Qi, Nan Li, Qiang Shi, Shengjian Mi, Cheng Pei
Article Number: 126
Published online on: 03 March 2026

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Case Report Open Access

Hematemesis resulting from mesenteric venous thrombosis: A case report

Chunyu Shi, Zhongmin Li, Lu Pan, Bin Song
Article Number: 125
Published online on: 02 March 2026

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Article

Inhibitory effects of spermidine on lipopolysaccharide‑induced inflammation in RAW 264.7 cells

Hao Yuan, Fang Peng, Yi-Feng Zhou, Si-Xian Wu, Zhen-Yi Long, Ya-Meng Peng, Yi-Zhao Zhou
Article Number: 124
Published online on: 02 March 2026

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Retraction Open Access

[Retracted] Telemedicine in clinical setting (Review)

Xiao-Ying Zhang, Peiying Zhang
Article Number: 123
Published online on: 02 March 2026

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Article

Effects of spironolactone on cytotoxic damage in osteoblasts

So Young Park, Kwang Sik Suh, Hyun-Sook Kim, Soo Jin Yun, Hyunji Sang, Sang Ouk Chin
Article Number: 122
Published online on: 27 February 2026

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Article Open Access

RNU2‑1 gene copy number variations do not affect serum levels of miR‑1246 as a biomarker for lung adenocarcinoma

Makiko Ueda, Shinya Sato, Yohei Miyagi, Toshiko Aiso
Article Number: 121
Published online on: 27 February 2026

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Article Open Access

A laboratory micro‑CT technique is useful to visualize and characterize dermal skin components in a 3D manner

Katarina Lundqvist, Hanna Tufvesson, Lars B. Dahlin, Marius Reichardt, Bodil Ohlsson
Article Number: 120
Published online on: 27 February 2026

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Case Report

A rare case of early‑onset cerebral syphilitic gummata with severe neurological decline in early‑stage syphilis: A case report

Yujie Ji, Shelin Liu, Yunwei Wang, Youcai Zhao, Zheng Cai, Bing Li
Article Number: 119
Published online on: 26 February 2026

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Review Open Access

Organelle homeostasis disruption: A driving force in the progression of cardiomyopathy (Review)

Yuxing Hou, Chao Li, Youyou Chen, Danfeng Zhong, Miaomiao Chai, Lijiao Mo, Senna Lin, Fangfang Huang, Qi Chen
Article Number: 118
Published online on: 26 February 2026

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Journal Cover
June-2026 Volume 31 Issue 6

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Impact Factor: 2.3

Article Open Access

Factors affecting central sensitization inventory score before surgery for distal radius fractures

Shoichiro Ishii, Kiyohito Naito, Norizumi Imazu, Takamaru Suzuki, Kenjiro Kawamura, So Kawakita, Tatsuki Itoh, Muneaki Ishijima
Article Number: 162
Published online on: 09 April 2026

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Article Open Access

Systemic immune‑inflammation index and neutrophil‑to‑lymphocyte ratio predict treatment responses in elderly patients with profound sudden deafness

Chong Li, Huili Wu, Hongxia Cui, Yue Li, Zhiming Sun, Siqi Haoliu, Xinfa Wei
Article Number: 161
Published online on: 09 April 2026

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Article Open Access

Efficacy analysis of percutaneous cannulated paravertebral approach for microscopic resection of intraspinal schwannomas: A case series

Shaobo Yang, Nianhua Wang
Article Number: 160
Published online on: 09 April 2026

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Case Report Open Access

3D‑printed customized semi‑restrictive elbow prosthesis for severe pseudoarthritis following comminuted fractures of the distal humerus: A case report and review

Bo Zheng, Xiu-Li Zhang, Yu-Xiang Cheng, Ze-Bi He, Peng Li
Article Number: 159
Published online on: 09 April 2026

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Article Open Access

α‑tocopherol in the prevention of ischemic or hemorrhagic stroke: A meta‑analysis

Peng Xu, Pengfei Cheng
Article Number: 158
Published online on: 09 April 2026

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Article Open Access

Preliminary study on symptoms and signs of patients with laryngopharyngeal reflux disease infected with Helicobacter pylori

Haixiang Zhang, Huanhuan Dang, Xin Wang, Yuxiang Zhao, Jinping Wang
Article Number: 157
Published online on: 09 April 2026

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Review Open Access

Autophagy‑epithelial‑mesenchymal transition crosstalk in acute respiratory distress syndrome: Mechanistic insights and therapeutic perspectives (Review)

Yue Zhang, Hongzhi He, Chufan Dong, Qing Guo, Jiuwen Tan, Yonggui Yang, Zhuangbo Guo, Rui Zhang
Article Number: 156
Published online on: 08 April 2026

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Review Open Access

Analysis of low‑benefit subgroups in breast‑conserving surgery: Implications for clinical decision‑making (Review)

Weicheng Lin, Lan Luo, Guiping Guo, Huan Lin
Article Number: 155
Published online on: 08 April 2026

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Case Report

Plexiform fibromyxoma of the lesser curvature of the stomach in a 16‑year‑old adolescent: A case report and literature review

Zhenhua Fu, Peiyao Tao, Da Sun, Xiang Chen
Article Number: 154
Published online on: 08 April 2026

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Case Report Open Access

Retroperitoneal ovarian venous hemangioma: A case report

Jie Tian, Hong Hu, Siyi Chen, Junping Li
Article Number: 153
Published online on: 08 April 2026

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Retraction Open Access

[Retracted] MicroRNA‑140‑5p regulates the proliferation, apoptosis and inflammation of RA FLSs by repressing STAT3

Jiehua Zhu, Jianglin Wang, Jialin Huang, Wensheng Du, Yingzhong He, Hongfei Pan, Junmin Luo
Article Number: 152
Published online on: 07 April 2026

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Article Open Access

Effects of rok1 gene deletion on mitosis in fission yeast at appropriate and stressful temperatures and the molecular mechanisms

Jiayi He, Mengnan Liu, Jiani Xu, Xiang Ding, Yiling Hou
Article Number: 151
Published online on: 02 April 2026

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Review Open Access

Therapeutic potential of allicin against viral infections: Mechanisms and safety profile (Review)

Ming-Jun Yu, Yong Zhu, Wei Zhang, Qiao-Ping Xu, Hai-Ming Wang, Zhao Ma
Article Number: 150
Published online on: 02 April 2026

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Article Open Access

Interacting proteins of AMPK studied using TurboID proximity labeling technology

Xiaoshan Liu, Jieyu Guo, Qiongyao Wang, Wu Liu, Yan Xue, Shuang Guo, Miao Li
Article Number: 149
Published online on: 02 April 2026

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Article Open Access

Multi‑omics analysis of glutamine and fish collagen peptides in alleviating post‑antibiotic Streptococcus pneumoniae injury in feline lung cells

Huasong Bai, Tong Liu, Hengyan Wang, Hongchen Jin, Yunliang Li, Zhanzhong Wang
Article Number: 148
Published online on: 30 March 2026

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Retraction Open Access

[Retracted] MicroRNA‑1236‑3p/translationally controlled tumor protein (TPT1) axis participates in congenital hypothyroidism progression by regulating neuronal apoptosis

Tingting Meng, Shiman Shen, Cheng Li, Xuehua Liu
Article Number: 147
Published online on: 30 March 2026

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