The use of Cox-2 and PPARγ signaling in anti-cancer therapies (Review)

  • Authors:
    • Lucia Knopfová
    • Jan Šmarda
  • View Affiliations

  • Published online on: March 1, 2010     https://doi.org/10.3892/etm_00000040
  • Pages: 257-264
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Abstract

Increased production of the pro-inflammatory enzyme cyclooxygenase-2 (Cox-2) and altered expression and activity of peroxisome proliferator-activated receptor γ (PPARγ) have been observed in many malignancies. Both the PPARγ ligands and the Cox-2 inhibitors possess anti-inflammatory and anti-neoplastic effects in vitro and have been assessed for their therapeutic potential in several pre-clinical and clinical studies. Recently, multiple interactions between PPARγ and Cox-2 signaling pathways have been revealed. Understanding of the cross-talk between PPARγ and Cox-2 might provide important novel strategies for the effective treatment and/or prevention of cancer. This article summarizes recent achievements involving the functional interactions between the PPARγ and Cox-2 signaling pathways and discusses the implications of such interplay for clinical use.
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March-April 2010
Volume 1 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Knopfová L and Knopfová L: The use of Cox-2 and PPARγ signaling in anti-cancer therapies (Review) . Exp Ther Med 1: 257-264, 2010
APA
Knopfová, L., & Knopfová, L. (2010). The use of Cox-2 and PPARγ signaling in anti-cancer therapies (Review) . Experimental and Therapeutic Medicine, 1, 257-264. https://doi.org/10.3892/etm_00000040
MLA
Knopfová, L., Šmarda, J."The use of Cox-2 and PPARγ signaling in anti-cancer therapies (Review) ". Experimental and Therapeutic Medicine 1.2 (2010): 257-264.
Chicago
Knopfová, L., Šmarda, J."The use of Cox-2 and PPARγ signaling in anti-cancer therapies (Review) ". Experimental and Therapeutic Medicine 1, no. 2 (2010): 257-264. https://doi.org/10.3892/etm_00000040