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Article

Telmisartan inhibits human urological cancer cell growth through early apoptosis

  • Authors:
    • Masahide Matsuyama
    • Kiyoaki Funao
    • Katsuyuki Kuratsukuri
    • Tomoaki Tanaka
    • Yutaka Kawahito
    • Hajime Sano
    • Jamel Chargui
    • Jean-Louis Touraine
    • Norio Yoshimura
    • Rikio Yoshimura
  • View Affiliations / Copyright

    Affiliations: Department of Transplantation and Clinical Immunology, Claude Bernard University of Lyon and Lyon Hospitals, Lyon, France
  • Pages: 301-306
    |
    Published online on: March 1, 2010
       https://doi.org/10.3892/etm_00000046
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Abstract

Angiotensin II receptor blockers (ARBs) are widely used as hypertensive therapeutic agents. In addition, studies have provided evidence that ARBs have the potential to inhibit the growth of several types of cancer cells. It was reported that telmisartan (a type of ARB) has peroxisome proliferator-activated receptor (PPAR)-γ activation activity. We previously reported that the PPAR-γ ligand induces growth arrest in human urological cancer cells through apoptosis. In this study, we evaluated the effects of telmisartan and other ARBs on cell proliferation in renal cell carcinoma (RCC), bladder cancer (BC), prostate cancer (PC) and testicular cancer (TC) cell lines. The inhibitory effects of telmisartan and other ARBs (candesartan, valsartan, irbesartan and losartan) on the growth of the RCC, BC, PC and TC cell lines was investigated using an MTT assay. Flow cytometry and Hoechst staining were used to determine whether the ARBs induced apoptosis. Telmisartan caused marked growth inhibition in the urological cancer cells in a dose- and time-dependent manner. Urological cancer cells treated with 100 µM telmisartan underwent early apoptosis and DNA fragmentation. However, the other ARBs had no effect on cell proliferation in any of the urological cancer cell lines. Telmisartan may mediate potent anti-proliferative effects in urological cancer cells through PPAR-γ. Thus, telmisartan is a potent target for the prevention and treatment of human urological cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Matsuyama M, Funao K, Kuratsukuri K, Tanaka T, Kawahito Y, Sano H, Chargui J, Touraine J, Yoshimura N, Yoshimura R, Yoshimura R, et al: Telmisartan inhibits human urological cancer cell growth through early apoptosis . Exp Ther Med 1: 301-306, 2010.
APA
Matsuyama, M., Funao, K., Kuratsukuri, K., Tanaka, T., Kawahito, Y., Sano, H. ... Yoshimura, R. (2010). Telmisartan inhibits human urological cancer cell growth through early apoptosis . Experimental and Therapeutic Medicine, 1, 301-306. https://doi.org/10.3892/etm_00000046
MLA
Matsuyama, M., Funao, K., Kuratsukuri, K., Tanaka, T., Kawahito, Y., Sano, H., Chargui, J., Touraine, J., Yoshimura, N., Yoshimura, R."Telmisartan inhibits human urological cancer cell growth through early apoptosis ". Experimental and Therapeutic Medicine 1.2 (2010): 301-306.
Chicago
Matsuyama, M., Funao, K., Kuratsukuri, K., Tanaka, T., Kawahito, Y., Sano, H., Chargui, J., Touraine, J., Yoshimura, N., Yoshimura, R."Telmisartan inhibits human urological cancer cell growth through early apoptosis ". Experimental and Therapeutic Medicine 1, no. 2 (2010): 301-306. https://doi.org/10.3892/etm_00000046
Copy and paste a formatted citation
x
Spandidos Publications style
Matsuyama M, Funao K, Kuratsukuri K, Tanaka T, Kawahito Y, Sano H, Chargui J, Touraine J, Yoshimura N, Yoshimura R, Yoshimura R, et al: Telmisartan inhibits human urological cancer cell growth through early apoptosis . Exp Ther Med 1: 301-306, 2010.
APA
Matsuyama, M., Funao, K., Kuratsukuri, K., Tanaka, T., Kawahito, Y., Sano, H. ... Yoshimura, R. (2010). Telmisartan inhibits human urological cancer cell growth through early apoptosis . Experimental and Therapeutic Medicine, 1, 301-306. https://doi.org/10.3892/etm_00000046
MLA
Matsuyama, M., Funao, K., Kuratsukuri, K., Tanaka, T., Kawahito, Y., Sano, H., Chargui, J., Touraine, J., Yoshimura, N., Yoshimura, R."Telmisartan inhibits human urological cancer cell growth through early apoptosis ". Experimental and Therapeutic Medicine 1.2 (2010): 301-306.
Chicago
Matsuyama, M., Funao, K., Kuratsukuri, K., Tanaka, T., Kawahito, Y., Sano, H., Chargui, J., Touraine, J., Yoshimura, N., Yoshimura, R."Telmisartan inhibits human urological cancer cell growth through early apoptosis ". Experimental and Therapeutic Medicine 1, no. 2 (2010): 301-306. https://doi.org/10.3892/etm_00000046
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