Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
March-April 2010 Volume 1 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-April 2010 Volume 1 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Association of a polymorphism of ROR2 and ischemic stroke in Japanese individuals with chronic kidney disease

  • Authors:
    • Mitsutoshi Oguri
    • Takanori Nagahiro
    • Haruo Kamiya
    • Miyoshi Ohno
    • Kimihiko Kato
    • Kiyoshi Yokoi
    • Tetsuro Yoshida
    • Sachiro Watanabe
    • Norifumi Metoki
    • Hidemi Yoshida
    • Kei Satoh
    • Yukitoshi Aoyagi
    • Yoshinori Nozawa
    • Yoshiji Yamada
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
  • Pages: 377-384
    |
    Published online on: March 1, 2010
       https://doi.org/10.3892/etm_00000059
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Although chronic kidney disease (CKD) is recognized as an important risk factor for ischemic stroke, genetic factors underlying predisposition to ischemic stroke in individuals with or without CKD remain largely unknown. The aim of the present study was to identify genetic variants that confer susceptibility to ischemic stroke in individuals with or without CKD in order to allow prediction of genetic risk for such individuals separately. The study population comprised 974 individuals with CKD, including 227 subjects with ischemic stroke and 747 controls, and 3,470 individuals without CKD, including 612 subjects with ischemic stroke and 2,858 controls. The 150 polymorphisms examined in the present study were selected by genome-wide association studies of ischemic stroke and myocardial infarction with the use of the GeneChip Human Mapping 500K Array Set (Affymetrix). In individuals with CKD, an initial Chi-square test revealed that the A↷G polymorphism (rs10992119) of the receptor tyrosine kinase-like orphan receptor 2 gene (ROR2) was significantly (false discovery rate for allele frequency, 0.0478) associated with ischemic stroke. Multivariable logistic regression analysis with adjustment for covariates revealed that the A↷G polymorphism of ROR2 was significantly (P=0.0100) associated with ischemic stroke (recessive model; odds ratio 1.57; 95% CI 1.12-2.23), with the G allele representing a risk factor for this condition. A stepwise forward selection procedure demonstrated that this polymorphism was a significant (P=0.0095) and independent determinant of ischemic stroke. In individuals without CKD, no polymorphism was significantly related to ischemic stroke. Genotyping for ROR2 may prove informative for assessment of the genetic risk for ischemic stroke in Japanese individuals with CKD. Determination of the genotype for this polymorphism may prove informative for assessment of the genetic risk for ischemic stroke in such individuals.
View Figures
View References

1. 

Bak S, Gaist D, Sindrup SH, Skytthe A and Christensen K: Genetic liability in stroke: a long-term follow-up study of Danish twins. Stroke. 33:769–774. 2002. View Article : Google Scholar : PubMed/NCBI

2. 

Tournier-Lasserve E: New players in the genetics of stroke. N Engl J Med. 347:1711–1712. 2002. View Article : Google Scholar : PubMed/NCBI

3. 

Touzé E and Rothwell PM: Heritability of ischaemic stroke in women compared with men: a genetic epidemiological study. Lancet Neurol. 6:125–133. 2007.PubMed/NCBI

4. 

Matarín M, Brown WM, Scholz S, et al: A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release. Lancet Neurol. 6:414–420. 2007.PubMed/NCBI

5. 

Kubo M, Hata J, Ninomiya T, et al: A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction. Nat Genet. 39:212–217. 2007. View Article : Google Scholar : PubMed/NCBI

6. 

Ikram MA, Seshadri S, Bis JC, et al: Genomewide association studies of stroke. N Engl J Med. 360:1718–1728. 2009. View Article : Google Scholar : PubMed/NCBI

7. 

Irie F, Iso H, Sairenchi T, et al: The relationships of proteinuria, serum creatinine, glomerular filtration rate with cardiovascular disease mortality in Japanese general population. Kidney Int. 69:1264–1271. 2006. View Article : Google Scholar

8. 

Yahalom G, Schwartz R, Schwammenthal Y, et al: Chronic kidney disease and clinical outcome in patients with acute stroke. Stroke. 40:1296–1303. 2009. View Article : Google Scholar : PubMed/NCBI

9. 

Muntner P, He J, Hamm L, Loria C and Whelton PK: Renal insufficiency and subsequent death resulting from cardiovascular disease in the United States. J Am Soc Nephrol. 13:745–753. 2002.PubMed/NCBI

10. 

Matsuo S, Imai E, Horio M, et al: Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis. 53:982–992. 2009. View Article : Google Scholar : PubMed/NCBI

11. 

Levey AS, Eckardt KU, Tsukamoto Y, et al: Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int. 67:2089–2100. 2005. View Article : Google Scholar : PubMed/NCBI

12. 

A committee established by the Director of the National Institute of Neurological Disorders and Stroke, National Institutes of Health: Special Report from the National Institute of Neurological Disorders and Stroke. Classification of Cerebrovascular Diseases III. Stroke. 21:637–676. 1990. View Article : Google Scholar : PubMed/NCBI

13. 

Yamada Y, Fuku N, Tanaka M, et al: Identification of CELSR1 as a susceptibility gene for ischemic stroke in Japanese individuals by a genome-wide association study. Atherosclerosis. 207:144–149. 2009.

14. 

Oguri M, Kato K, Yokoi K, et al: Association of a polymorphism of BCHE with ischemic stroke in Japanese individuals with chronic kidney disease. Mol Med Rep. 2:779–785. 2009.PubMed/NCBI

15. 

Yamada Y, Kato K, Oguri M, et al: Association of genetic variants with atherothrombotic cerebral infarction among Japanese individuals with metabolic syndrome. Int J Mol Med. 21:801–808. 2008.PubMed/NCBI

16. 

Yamada Y, Metoki N, Yoshida H, et al: Genetic factors for ischemic and hemorrhagic stroke in Japanese individuals. Stroke. 39:2211–2218. 2008. View Article : Google Scholar : PubMed/NCBI

17. 

Yamada Y, Metoki N, Yoshida H, et al: Genetic risk for ischemic and hemorrhagic stroke. Arterioscler Thromb Vasc Biol. 26:1920–1925. 2006. View Article : Google Scholar : PubMed/NCBI

18. 

Itoh Y, Mizuki N, Shimada T, et al: High-throughput DNA typing of HLA-A, -B, -C and -DRB1 loci by a PCR-SSOP-Luminex method in the Japanese population. Immunogenetics. 57:717–729. 2005. View Article : Google Scholar : PubMed/NCBI

19. 

Benjamini Y and Hochberg Y: Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Royal Stat Soc Ser B. 57:289–300. 1995.

20. 

Goldstein LB, Adams R, Becker K, et al: Primary prevention of ischemic stroke: a statement for healthcare professionals from the Stroke Council of the American Heart Association. Stroke. 32:280–299. 2001. View Article : Google Scholar

21. 

Humphries SE and Morgan L: Genetic risk factors for stroke and carotid atherosclerosis: insights into pathophysiology from candidate gene approaches. Lancet Neurol. 3:227–235. 2004. View Article : Google Scholar : PubMed/NCBI

22. 

Masiakowski P and Carroll RD: A novel family of cell surface receptors with tyrosine kinase-like domain. J Biol Chem. 267:26181–26190. 1992.PubMed/NCBI

23. 

Forrester WC: The Ror receptor tyrosine kinase family. Cell Mol Life Sci. 59:83–96. 2002. View Article : Google Scholar : PubMed/NCBI

24. 

Stommel JM, Kimmelman AC, Ying H, et al: Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science. 318:287–290. 2007. View Article : Google Scholar : PubMed/NCBI

25. 

Schlessinger J: Cell signaling by receptor tyrosine kinases. Cell. 103:211–225. 2000. View Article : Google Scholar : PubMed/NCBI

26. 

Yoda A, Oishi I and Minami Y: Expression and function of the Ror-family receptor tyrosine kinases during development: lessons from genetic analyses of nematodes, mice and humans. J Recept Signal Transduct Res. 23:1–15. 2003. View Article : Google Scholar : PubMed/NCBI

27. 

Afzal AR, Rajab A, Fenske CD, et al: Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2. Nat Genet. 25:419–422. 2000. View Article : Google Scholar : PubMed/NCBI

28. 

Oldridge M, Fortuna AM, Maringa M, et al: Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B. Nat Genet. 24:275–278. 2000. View Article : Google Scholar : PubMed/NCBI

29. 

Katoh M and Katoh M: Comparative genomics on ROR1 and ROR2 orthologs. Oncol Rep. 14:1381–1384. 2005.PubMed/NCBI

30. 

Wright TM, Brannon AR, Gordan JD, et al: Ror2, a developmentally regulated kinase, promotes tumor growth potential in renal cell carcinoma. Oncogene. 28:2513–2523. 2009. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Oguri M, Nagahiro T, Kamiya H, Ohno M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Yoshida H, et al: Association of a polymorphism of ROR2 and ischemic stroke in Japanese individuals with chronic kidney disease . Exp Ther Med 1: 377-384, 2010.
APA
Oguri, M., Nagahiro, T., Kamiya, H., Ohno, M., Kato, K., Yokoi, K. ... Yamada, Y. (2010). Association of a polymorphism of ROR2 and ischemic stroke in Japanese individuals with chronic kidney disease . Experimental and Therapeutic Medicine, 1, 377-384. https://doi.org/10.3892/etm_00000059
MLA
Oguri, M., Nagahiro, T., Kamiya, H., Ohno, M., Kato, K., Yokoi, K., Yoshida, T., Watanabe, S., Metoki, N., Yoshida, H., Satoh, K., Aoyagi, Y., Nozawa, Y., Yamada, Y."Association of a polymorphism of ROR2 and ischemic stroke in Japanese individuals with chronic kidney disease ". Experimental and Therapeutic Medicine 1.2 (2010): 377-384.
Chicago
Oguri, M., Nagahiro, T., Kamiya, H., Ohno, M., Kato, K., Yokoi, K., Yoshida, T., Watanabe, S., Metoki, N., Yoshida, H., Satoh, K., Aoyagi, Y., Nozawa, Y., Yamada, Y."Association of a polymorphism of ROR2 and ischemic stroke in Japanese individuals with chronic kidney disease ". Experimental and Therapeutic Medicine 1, no. 2 (2010): 377-384. https://doi.org/10.3892/etm_00000059
Copy and paste a formatted citation
x
Spandidos Publications style
Oguri M, Nagahiro T, Kamiya H, Ohno M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Yoshida H, et al: Association of a polymorphism of ROR2 and ischemic stroke in Japanese individuals with chronic kidney disease . Exp Ther Med 1: 377-384, 2010.
APA
Oguri, M., Nagahiro, T., Kamiya, H., Ohno, M., Kato, K., Yokoi, K. ... Yamada, Y. (2010). Association of a polymorphism of ROR2 and ischemic stroke in Japanese individuals with chronic kidney disease . Experimental and Therapeutic Medicine, 1, 377-384. https://doi.org/10.3892/etm_00000059
MLA
Oguri, M., Nagahiro, T., Kamiya, H., Ohno, M., Kato, K., Yokoi, K., Yoshida, T., Watanabe, S., Metoki, N., Yoshida, H., Satoh, K., Aoyagi, Y., Nozawa, Y., Yamada, Y."Association of a polymorphism of ROR2 and ischemic stroke in Japanese individuals with chronic kidney disease ". Experimental and Therapeutic Medicine 1.2 (2010): 377-384.
Chicago
Oguri, M., Nagahiro, T., Kamiya, H., Ohno, M., Kato, K., Yokoi, K., Yoshida, T., Watanabe, S., Metoki, N., Yoshida, H., Satoh, K., Aoyagi, Y., Nozawa, Y., Yamada, Y."Association of a polymorphism of ROR2 and ischemic stroke in Japanese individuals with chronic kidney disease ". Experimental and Therapeutic Medicine 1, no. 2 (2010): 377-384. https://doi.org/10.3892/etm_00000059
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team