Involvement of calpain in colorectal adenocarcinomas (Review)

  • Authors:
    • Ponniah Selvakumar
    • Rajendra K. Sharma
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  • Published online on: May 1, 2010     https://doi.org/10.3892/etm_00000064
  • Pages: 413-417
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Abstract

Calpains represent a well-conserved family of Ca2+-dependent proteolytic enzymes. Recently, the importance of calpain in the metastatic process has received a great deal of attention. Various reports have suggested that m-calpain contributes to the pathogenesis of various cancers, including colorectal cancer. The activity and protein expression of m-calpain was significantly higher in colorectal adenocarcinoma than in normal colonic mucosa as revealed by Western blotting and immunohistochemical analysis. In addition, the decreased expression of calpain inhibitors (calpastatin and high molecular weight calmodulin-binding protein) was correlated with the increased activity and expression of calpain in colorectal adenocarcinoma. This has implications with regard to the design of chemotherapeutic drugs as well as for the monitoring of colorectal cancer in the early stages of the metastatic process. In this review, we summarize some of the recent findings from our laboratory regarding calpain and its inhibitors in human colon cancer.
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May-June 2010
Volume 1 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Selvakumar P and Selvakumar P: Involvement of calpain in colorectal adenocarcinomas (Review) . Exp Ther Med 1: 413-417, 2010
APA
Selvakumar, P., & Selvakumar, P. (2010). Involvement of calpain in colorectal adenocarcinomas (Review) . Experimental and Therapeutic Medicine, 1, 413-417. https://doi.org/10.3892/etm_00000064
MLA
Selvakumar, P., Sharma, R. K."Involvement of calpain in colorectal adenocarcinomas (Review) ". Experimental and Therapeutic Medicine 1.3 (2010): 413-417.
Chicago
Selvakumar, P., Sharma, R. K."Involvement of calpain in colorectal adenocarcinomas (Review) ". Experimental and Therapeutic Medicine 1, no. 3 (2010): 413-417. https://doi.org/10.3892/etm_00000064