Infective endocarditis associated with acute renal failure: Repeat renal biopsy and successful recovery

Wang,Aifeng; Wang,Yongping; Wang,Guobao; Zhou,Zhanmei; Yang,Xiaobing

doi:10.3892/etm_00000067

May-June 2010 Volume 1 Issue 3

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May-June 2010 Volume 1 Issue 3

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Article

Infective endocarditis associated with acute renal failure: Repeat renal biopsy and successful recovery

Authors:
- Aifeng Wang
- Yongping Wang
- Guobao Wang
- Zhanmei Zhou
- Xiaobing Yang
View Affiliations / Copyright

Affiliations: Department of Forensic Medicine, Southern Medical University, Guangzhou 510515, P.R. China
Pages: 433-436
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Published online on: May 1, 2010

https://doi.org/10.3892/etm_00000067
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Abstract

Infective endocarditis (IE) is a serious disease with a high associated mortality rate, particularly when complicated by acute renal failure (ARF). Although valve surgery and treatment with antibiotic agents are recommended, surgical options and the optimal therapy are not as yet well documented. Here, we report a rare case of IE in a young man with a history of intravenous drug abuse, who presented with high fever, bilateral thoracalgia, lower limb edema and renal dysfunction. After treatment with antibiotics, hemodialysis and anticoagulants, a tricuspid valve replacement surgery was performed on the patient. After surgery, his renal functions deteriorated and progressed to ARF. The first renal biopsy showed type II crescentic glomerulonephritis. After receiving continuous ambulatory peritoneal dialysis followed by administration of an angiotensin converting enzyme inhibitor and angiotensin receptor blockers, the patient's serum creatinine level decreased and the urine output increased gradually. In order to identify the renal turnover, we performed a second biopsy and found significant improvement in the pathological changes with endocapillary proliferative glomerulonephritis and fibrous crescents. Successful recovery of renal function was achieved 12 weeks after the initiation of therapy. Therefore, eradication of infection, tricuspid valve replacement and renal substitution therapy may be sufficient in some cases.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Infective endocarditis associated with acute renal failure: Repeat renal biopsy and successful recovery

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