Effects of pre-operative transcatheter arterial chemoembolization for resectable hepatocellular carcinoma: Implication of circulating cancer cells by detection of α-fetoprotein mRNA

  • Authors:
    • Masahiro Murakami
    • Hiroaki Nagano
    • Shogo Kobayashi
    • Hiroshi Wada
    • Masato Nakamura
    • Shigeru Marubashi
    • Hidetoshi Eguchi
    • Yutaka Takeda
    • Masahiro Tanemura
    • Koji Umeshita
    • Yuichiro Doki
    • Masaki Mori
  • View Affiliations

  • Published online on: May 1, 2010     https://doi.org/10.3892/etm_00000076
  • Pages: 485-491
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Transcatheter arterial chemoembolization (TACE) is useful for the treatment of multiple hepatocellular carcinomas (HCCs). Pre-operative TACE is used to reduce recurrence caused by peri- and post-operative spread of cancer cells; however, the efficacy is controversial. In this study, we evaluated the efficacy of pre-operative TACE for HCC and the implication of circulating cancer cells, retrospectively. We analyzed 495 patients with HCC who had undergone hepatectomy between 1980 and 2006, including 252 patients (50.9%) who received pre-operative TACE. The median follow-up period was 49.9 months. We compared the survival of TACE and non-TACE groups and also performed subgroup analysis. α-fetoprotein (AFP) mRNA was quantified to represent circulating cancer cells. Pre-operative TACE prolonged disease-free survival after hepatectomy in patients with HCCs greater than 5 cm (5-year disease-free survival of the pre-operative TACE and no-TACE groups was 37.3 vs. 14.8%, p<0.05). Patients with tumors showing 70% or greater necrosis had a significantly more favorable survival, and those with complete necrosis were all AFP mRNA-negative. The survival of the AFP mRNA-positive patients was worse than that of the AFP mRNA-negative patients. Pre-operative TACE may be beneficial for patients with tumors larger than 5 cm, and AFP mRNA quantification may be useful for the prediction of survival after surgery in TACE-treated patients.
View Figures
View References

Related Articles

Journal Cover

May-June 2010
Volume 1 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Murakami M, Nagano H, Kobayashi S, Wada H, Nakamura M, Marubashi S, Eguchi H, Takeda Y, Tanemura M, Umeshita K, Umeshita K, et al: Effects of pre-operative transcatheter arterial chemoembolization for resectable hepatocellular carcinoma: Implication of circulating cancer cells by detection of α-fetoprotein mRNA . Exp Ther Med 1: 485-491, 2010.
APA
Murakami, M., Nagano, H., Kobayashi, S., Wada, H., Nakamura, M., Marubashi, S. ... Mori, M. (2010). Effects of pre-operative transcatheter arterial chemoembolization for resectable hepatocellular carcinoma: Implication of circulating cancer cells by detection of α-fetoprotein mRNA . Experimental and Therapeutic Medicine, 1, 485-491. https://doi.org/10.3892/etm_00000076
MLA
Murakami, M., Nagano, H., Kobayashi, S., Wada, H., Nakamura, M., Marubashi, S., Eguchi, H., Takeda, Y., Tanemura, M., Umeshita, K., Doki, Y., Mori, M."Effects of pre-operative transcatheter arterial chemoembolization for resectable hepatocellular carcinoma: Implication of circulating cancer cells by detection of α-fetoprotein mRNA ". Experimental and Therapeutic Medicine 1.3 (2010): 485-491.
Chicago
Murakami, M., Nagano, H., Kobayashi, S., Wada, H., Nakamura, M., Marubashi, S., Eguchi, H., Takeda, Y., Tanemura, M., Umeshita, K., Doki, Y., Mori, M."Effects of pre-operative transcatheter arterial chemoembolization for resectable hepatocellular carcinoma: Implication of circulating cancer cells by detection of α-fetoprotein mRNA ". Experimental and Therapeutic Medicine 1, no. 3 (2010): 485-491. https://doi.org/10.3892/etm_00000076