Correlation of granulin expression in intracranial meningiomas to clinical parameters

Kim,Choong H.; Cheong,Jin H.; Kim,Jae M.

doi:10.3892/etm_00000077

Correlation of granulin expression in intracranial meningiomas to clinical parameters

Authors:
- Choong H. Kim
- Jin H. Cheong
- Jae M. Kim
View Affiliations

Affiliations: Department of Neurosurgery, Hanyang University Guri Hospital, Guri Gyeonggi-Do 471-701, Korea. kch5142@hanyang.ac.kr
Published online on: May 1, 2010 https://doi.org/10.3892/etm_00000077
Pages: 493-496

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

The granulins, a novel class of peptides from leukocytes, are growth factors that mediate cycle progression and the motility of epithelial and mesenchymal cells. They are also involved in tissue repair and tumorigenesis. We investigated granulin expression in intracranial meningiomas by reverse transcription-polymerase chain reaction and correlated its expression to clinical parameters. Seventy-nine patients who underwent tumor removal for intracranial meningiomas were included in this study. Granulin expression was analyzed in respect to clinical parameters including age, gender, tumor size and peritumoral brain edema (PTBE). Granulin was expressed in the tumors of 29 of 79 (36.7%) patients with intracranial meningiomas, and its presence or absence was correlated to tumor size and PTBE volume. However, granulin expression did not vary significantly according to patient age or gender. Our data provide improved understanding about the clinical implications of granulin expression in intracranial meningiomas. Additionally, our information suggests a potential role for granulin as a molecular target in the management of meningiomas.

View Figures

View References

1.	Cross M and Dexter TM: Growth factors in development, transformation and tumorigenesis. Cell. 64:271–284. 1991. View Article : Google Scholar : PubMed/NCBI
2.	Morrison RS, Jarell AD and Schuster JM: Growth factors and brain tumors. Youmans Neurological Surgery. Winn HR: Saunders; Philadelphia: pp. 725–738. 2004
3.	Lingood RM, Hsu DW, Efird JT and Pardo FS: TGF alpha expression in meningioma-tumor progression and therapeutic response. J Neurooncol. 26:45–51. 1995. View Article : Google Scholar : PubMed/NCBI
4.	Braun B, Lange M, Oeckler R and Mueller MM: Expression of G-CSF and GM-CSF in human meningiomas correlates with increased tumor proliferation and vascularization. J Neurooncol. 68:131–140. 2004. View Article : Google Scholar : PubMed/NCBI
5.	Lamszus K, Lengler U, Schmidt NO, Stavrou D, Ergün S and Westphal M: Vascular endothelial growth factor, basic fibroblast growth factor and placenta growth factor in human meningiomas and their relation to angiogenesis and malignancy. Neurosurgery. 46:938–948. 2000.PubMed/NCBI
6.	Bateman A and Bennett HP: The granulin gene family from cancer to dementia. Bioassay. 31:1245–1254. 2009. View Article : Google Scholar : PubMed/NCBI
7.	Bateman A, Belcourt D, Benett HPJ, Hazure C and Solomon S: Granulins, a novel class of peptides from leukocytes. Biochem Biophys Res Commun. 173:1161–1168. 1993. View Article : Google Scholar
8.	Donald CD, Laddu A, Chandham P, et al: Expression of progranulin and the epithelin/granulin precursor acrogranin correlates with neoplastic state in renal epithelium. Anticancer Res. 21:3739–3742. 2001.PubMed/NCBI
9.	Liau LM, Lallone RL, Seitz RS, et al: Identification of a human glioma-associated growth factor gene, granulin, using differential immuno-absorption. Cancer Res. 60:1353–1360. 2000.PubMed/NCBI
10.	Line AA, Stengrevics Z, Slucka GL, Jankevics E and Rees RC: Serological identification and expression analysis of gastric cancer-associated genes. Br J Cancer. 86:1824–1830. 2002. View Article : Google Scholar : PubMed/NCBI
11.	Lu R and Serrero G: Inhibition of PC cell-derived growth factor (PCDGF, epithelin/granulin precursor) expression by antisense PCDGF cDNA transfection inhibits tumorigenicity of the human breast carcinoma cell line MDA-MB-468. Proc Natl Acad Sci USA. 97:3993–3998. 2000. View Article : Google Scholar
12.	Lu R and Serrero G: Stimulation of PC cell-derived growth factor (epithelin/granulin precursor) expression by estradiol in human breast cancer cell. Biochem Biophys Res Commun. 256:204–207. 1999. View Article : Google Scholar : PubMed/NCBI
13.	Otsuka S, Tamiya T, Ono Y, et al: The relationship between peritumoral edema and the exression of vascular endothelial growth factor and its receptors in intracranial meningiomas. J Neurooncol. 70:349–357. 2004. View Article : Google Scholar
14.	Haddad GF, Al-Mefty O and Abdulrauf SI: Meningiomas. Youmans Neurological Surgery. Winn HR: Saunders; Philadelphia: pp. 1099–1131. 2004
15.	Davidson B, Alejandro E, Florenes VA, Goderstad JM, Kristensen GB, Trope CG and Kohn EC: Granulin-epithelin precursor is a novel prognostic marker in epithelial ovarian carcinoma. Cancer. 100:2139–2147. 2004. View Article : Google Scholar : PubMed/NCBI
16.	Davidson B, Risberg R, Reich R and Berner A: Effusion cytology in ovarian cancer – new molecular methods as aids to diagnosis and prognosis. Clin Lab Med. 23:729–754. 2003.
17.	He Z and Bateman A: Progranulin (granulin-epithelin precursor, PC-cell derived growth factor, acrogranin) mediates tissue repair and tumorigenesis. J Mol Med. 81:600–612. 2003. View Article : Google Scholar : PubMed/NCBI
18.	Jemal H, Murray T, Samuels A, Ghafoor A, Ward E and Thun MJ: Cancer Statistics 2003. CA Cancer J Clin. 53:5–26. 2003. View Article : Google Scholar
19.	Ong CHP and Bateman A: Progranulin (granulin-epithelin precursor, PC-cell derived growth factor, acrogranin) in proliferation and tumorigenesis. Histol Histopathol. 18:1275–1288. 2003.PubMed/NCBI
20.	Hoque M, Young TM, Lee CG, Serrero G, Mathews MB and Pe’ery T: The growth factor granulin interacts with cyclin T1, and modulates p-TEFb-dependent transcription. Mol Cell Biol. 23:1688–1702. 2003. View Article : Google Scholar : PubMed/NCBI
21.	Sparro G, Galdenzi G, Eleuteri AM, Angeletti M, Schroeder W and Fioretti E: Isolation and N-terminal sequence of multiple forms of granulins in human urine. Protein Expr Purif. 10:169–174. 1997. View Article : Google Scholar : PubMed/NCBI
22.	Bhandari V and Bateman A: Structure and chromosomal location of the human granulin gene. Biochem Biophys Res Commun. 188:57–63. 1992. View Article : Google Scholar : PubMed/NCBI
23.	Baba T, Hoff HB III, Nemoto H, Lee H, Orth J, Arai Y and Gertan GL: Acrogranin, an autosomal cysteine-rich glycoprotein, is the precursors of the growth-modulating peptides, granulin and epithelins and is expressed in somatic as well as male germ cells. Mol Reprod Dev. 34:233–243. 1993. View Article : Google Scholar : PubMed/NCBI
24.	Bhandari V, Giad A and Bateman A: The cDNA structure, tissue distribution and cellular localization of the rat granulin precursors: a novel growth factor-like protein. Endocrinology. 133:2682–2689. 1993.PubMed/NCBI
25.	Bhandari V, Palfree RG and Bateman A: Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains. Proc Natl Acad Sci USA. 89:1715–1719. 1992. View Article : Google Scholar : PubMed/NCBI
26.	Van Damme P, van Hoecke A, Lambrechts D, Vanacker P, Bogaert E, van Swieten J, Carmeliet P, van Den Bosch L and Robberecht W: Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival. J Cell Biol. 181:37–41. 2008.PubMed/NCBI