Myofibroblasts are associated with the progression of scirrhous gastric carcinoma

Fuyuhiro,Yuhiko; Yashiro,Masakazu; Noda,Satoru; Kashiwagi,Shinichiro; Matsuoka,Junko; Doi,Yosuke; Kato,Yukihiro; Muguruma,Kazuya; Sawada,Tetsuji; Hirakawa,Kosei

doi:10.3892/etm_00000086

July-August 2010 Volume 1 Issue 4

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July-August 2010 Volume 1 Issue 4

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Myofibroblasts are associated with the progression of scirrhous gastric carcinoma

Authors:
- Yuhiko Fuyuhiro
- Masakazu Yashiro
- Satoru Noda
- Shinichiro Kashiwagi
- Junko Matsuoka
- Yosuke Doi
- Yukihiro Kato
- Kazuya Muguruma
- Tetsuji Sawada
- Kosei Hirakawa
View Affiliations / Copyright

Affiliations: Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan
Pages: 547-551
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Published online on: July 1, 2010

https://doi.org/10.3892/etm_00000086
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Abstract

Fibroblasts, particularly myofibroblasts, affect the malignant progression of cancer cells in vitro. However, to date few reports have addressed the clinical significance of myofibroblasts in the gastric cancer microenvironment. This study examined the correlation between myofibroblast expression and clinicopathological features in gastric carcinoma. A total of 265 primary gastric tumors resected by gastrectomy were stained with antibodies against α-smooth muscle actin and vimentin. Stromal cells positive for vimentin were considered to be fibroblasts. Myofibroblasts were defined as fibroblasts positive for α-smooth muscle staining. Myofibroblast-positive gastric carcinoma was established when myofibroblasts accounted for more than 25% of fibroblasts in the cancer stroma. Myofibroblast expression was positive in 92 (35%) of the 265 gastric carcinomas. Myofibroblast expression showed a significantly (p<0.001) high frequency in advanced gastric cancers (76 of 146), in comparison to the early stage cancers (16 of 119). Taken together, there was a statistically significant correlation between myofibroblast expression and scirrhous type gastric cancer (p<0.001), lymph node metastasis (p<0.001), lymphatic invasion (p<0.001) and peritoneal dissemination (p=0.005). The prognosis of patients with tumors positive for myofibroblast expression was significantly (p<0.001) worse, while a multivariate analysis revealed that myofibroblast expression was not an independent prognostic factor. These findings suggest that myofibroblasts are associated with scirrhous gastric cancer. Overexpression of myofibroblasts may therefore be a useful prognostic indicator of gastric carcinoma.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Myofibroblasts are associated with the progression of scirrhous gastric carcinoma

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Abstract

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