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Article

Alteration of extracellular superoxide dismutase expression is associated with an aggressive phenotype of oral squamous-cell carcinoma

  • Authors:
    • Hidetaka Yokoe
    • Hitomi Nomura
    • Yukio Yamano
    • Kazuaki Fushimi
    • Yosuke Sakamoto
    • Katsunori Ogawara
    • Masashi Shiiba
    • Hiroki Bukawa
    • Katsuhiro Uzawa
    • Yuichi Takiguchi
    • Hideki Tanzawa
  • View Affiliations / Copyright

    Affiliations: Division of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital, Chiba 260-8670, Japan
  • Pages: 585-590
    |
    Published online on: July 1, 2010
       https://doi.org/10.3892/etm_00000092
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Abstract

Oxidative stress results in damage to cellular structures and has been linked to numerous diseases, including cancer. Extracellular superoxide dismutase (EC-SOD) is a principal enzymatic antioxidant in extracellular space. The purpose of this study was to determine whether the expression of EC-SOD protein is altered in the carcinogenetic process of oral squamous-cell carcinoma (OSCC). Immunohistochemical analysis was carried out in matched normal and tumour specimens collected from 58 OSCCs and 20 oral premalignant lesions (OPLs). Correlations between the EC-SOD expression levels and clinicopathological features of OSCC patients were evaluated by Fisher's exact test. Although EC-SOD protein was consistently expressed on the plasma membrane of cells in normal tissues, plasma membranous EC-SOD expression was lost in almost all the OSCC specimens examined (98%). Instead, positive EC-SOD expression was detected in the cytoplasmic compartments of cancerous cells in both OPLs (65%) and OSCCs (52%), together with a high incidence of lymph node metastasis (p=0.0397). These results suggest that the dysregulation of EC-SOD protein expression is a frequently occuring and early event in oral carcinogenesis, and that cytoplasmic EC-SOD may contribute to the increased aggressiveness of OSCC.
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Copy and paste a formatted citation
Spandidos Publications style
Yokoe H, Nomura H, Yamano Y, Fushimi K, Sakamoto Y, Ogawara K, Shiiba M, Bukawa H, Uzawa K, Takiguchi Y, Takiguchi Y, et al: Alteration of extracellular superoxide dismutase expression is associated with an aggressive phenotype of oral squamous-cell carcinoma . Exp Ther Med 1: 585-590, 2010.
APA
Yokoe, H., Nomura, H., Yamano, Y., Fushimi, K., Sakamoto, Y., Ogawara, K. ... Tanzawa, H. (2010). Alteration of extracellular superoxide dismutase expression is associated with an aggressive phenotype of oral squamous-cell carcinoma . Experimental and Therapeutic Medicine, 1, 585-590. https://doi.org/10.3892/etm_00000092
MLA
Yokoe, H., Nomura, H., Yamano, Y., Fushimi, K., Sakamoto, Y., Ogawara, K., Shiiba, M., Bukawa, H., Uzawa, K., Takiguchi, Y., Tanzawa, H."Alteration of extracellular superoxide dismutase expression is associated with an aggressive phenotype of oral squamous-cell carcinoma ". Experimental and Therapeutic Medicine 1.4 (2010): 585-590.
Chicago
Yokoe, H., Nomura, H., Yamano, Y., Fushimi, K., Sakamoto, Y., Ogawara, K., Shiiba, M., Bukawa, H., Uzawa, K., Takiguchi, Y., Tanzawa, H."Alteration of extracellular superoxide dismutase expression is associated with an aggressive phenotype of oral squamous-cell carcinoma ". Experimental and Therapeutic Medicine 1, no. 4 (2010): 585-590. https://doi.org/10.3892/etm_00000092
Copy and paste a formatted citation
x
Spandidos Publications style
Yokoe H, Nomura H, Yamano Y, Fushimi K, Sakamoto Y, Ogawara K, Shiiba M, Bukawa H, Uzawa K, Takiguchi Y, Takiguchi Y, et al: Alteration of extracellular superoxide dismutase expression is associated with an aggressive phenotype of oral squamous-cell carcinoma . Exp Ther Med 1: 585-590, 2010.
APA
Yokoe, H., Nomura, H., Yamano, Y., Fushimi, K., Sakamoto, Y., Ogawara, K. ... Tanzawa, H. (2010). Alteration of extracellular superoxide dismutase expression is associated with an aggressive phenotype of oral squamous-cell carcinoma . Experimental and Therapeutic Medicine, 1, 585-590. https://doi.org/10.3892/etm_00000092
MLA
Yokoe, H., Nomura, H., Yamano, Y., Fushimi, K., Sakamoto, Y., Ogawara, K., Shiiba, M., Bukawa, H., Uzawa, K., Takiguchi, Y., Tanzawa, H."Alteration of extracellular superoxide dismutase expression is associated with an aggressive phenotype of oral squamous-cell carcinoma ". Experimental and Therapeutic Medicine 1.4 (2010): 585-590.
Chicago
Yokoe, H., Nomura, H., Yamano, Y., Fushimi, K., Sakamoto, Y., Ogawara, K., Shiiba, M., Bukawa, H., Uzawa, K., Takiguchi, Y., Tanzawa, H."Alteration of extracellular superoxide dismutase expression is associated with an aggressive phenotype of oral squamous-cell carcinoma ". Experimental and Therapeutic Medicine 1, no. 4 (2010): 585-590. https://doi.org/10.3892/etm_00000092
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