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Article

Relationship between the production of autoantibodies to oxidized low-density lipoprotein and hepatic steatosis in patients with chronic hepatitis C

  • Authors:
    • Takashi Himoto
    • Hirohito Yoneyama
    • Akihiro Deguchi
    • Kazutaka Kurokohchi
    • Michio Inukai
    • Hisashi Masugata
    • Fuminori Goda
    • Shoichi Senda
    • Reiji Haba
    • Seishiro Watanabe
    • Mikio Nishioka
    • Tsutomu Masaki
  • View Affiliations / Copyright

    Affiliations: Department of Integrated Medicine, Kagawa University School of Medicine, Kita-Gun, Kagawa 761-0793, Japan. thimoto@med.kagawa-u.ac.jp
  • Pages: 663-668
    |
    Published online on: July 1, 2010
       https://doi.org/10.3892/etm_00000104
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Abstract

Persistent hepatitis C virus (HCV) infection induces oxidative stress and eventually leads to hepatic steatosis. Oxidatively modified autoantigens, including oxidized low-density lipoprotein (ox-LDL), were identified in patients with systemic lupus erythematosus. Chronic HCV infection often evokes autoimmune phenomena, such as autoantibody production and/or concurrent autoimmune diseases. We examined the relationship between the production of antibodies to ox-LDL (anti-ox-LDL) and hepatic steatosis in patients with chronic hepatitis C (CH-C). Anti-ox-LDL levels were determined by the enzyme-linked immunosorbent assay method. The severity of hepatic steatosis was evaluated using the classification proposed by Brunt and colleagues. The effect of antiviral treatment was also investigated. Twenty-two (52%) of the 42 patients with CH-C had no hepatic steatosis (grade 0), while 12 (29%) and 8 (19%) had grade 1 and 2 hepatic steatosis, respectively. The overall serum immunoglobulin G (IgG) level in patients with grade 2 steatosis was significantly higher than that in patients with grade 0 steatosis (1,999±340 vs. 1,465±196 mg/dl, p<0.0001). The mean anti-ox-LDL level in grade 2 steatosis patients was also higher than that in grade 0 steatosis patients (754±479 vs. 361±274 mU/ml, p=0.0165). A close correlation was apparent between anti-ox-LDL and serum IgG levels (r=0.390, p=0.0107). There was no significant difference in the level of anti-ox-LDL between CH-C patients who acquired sustained virological response (SVR) and those who exhibited non-SVR. These findings suggest that anti-ox-LDL in patients with CH-C is induced in the process of hepatic steatosis and that the emergence of anti-ox-LDL does not affect antiviral treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Himoto T, Yoneyama H, Deguchi A, Kurokohchi K, Inukai M, Masugata H, Goda F, Senda S, Haba R, Watanabe S, Watanabe S, et al: Relationship between the production of autoantibodies to oxidized low-density lipoprotein and hepatic steatosis in patients with chronic hepatitis C . Exp Ther Med 1: 663-668, 2010.
APA
Himoto, T., Yoneyama, H., Deguchi, A., Kurokohchi, K., Inukai, M., Masugata, H. ... Masaki, T. (2010). Relationship between the production of autoantibodies to oxidized low-density lipoprotein and hepatic steatosis in patients with chronic hepatitis C . Experimental and Therapeutic Medicine, 1, 663-668. https://doi.org/10.3892/etm_00000104
MLA
Himoto, T., Yoneyama, H., Deguchi, A., Kurokohchi, K., Inukai, M., Masugata, H., Goda, F., Senda, S., Haba, R., Watanabe, S., Nishioka, M., Masaki, T."Relationship between the production of autoantibodies to oxidized low-density lipoprotein and hepatic steatosis in patients with chronic hepatitis C ". Experimental and Therapeutic Medicine 1.4 (2010): 663-668.
Chicago
Himoto, T., Yoneyama, H., Deguchi, A., Kurokohchi, K., Inukai, M., Masugata, H., Goda, F., Senda, S., Haba, R., Watanabe, S., Nishioka, M., Masaki, T."Relationship between the production of autoantibodies to oxidized low-density lipoprotein and hepatic steatosis in patients with chronic hepatitis C ". Experimental and Therapeutic Medicine 1, no. 4 (2010): 663-668. https://doi.org/10.3892/etm_00000104
Copy and paste a formatted citation
x
Spandidos Publications style
Himoto T, Yoneyama H, Deguchi A, Kurokohchi K, Inukai M, Masugata H, Goda F, Senda S, Haba R, Watanabe S, Watanabe S, et al: Relationship between the production of autoantibodies to oxidized low-density lipoprotein and hepatic steatosis in patients with chronic hepatitis C . Exp Ther Med 1: 663-668, 2010.
APA
Himoto, T., Yoneyama, H., Deguchi, A., Kurokohchi, K., Inukai, M., Masugata, H. ... Masaki, T. (2010). Relationship between the production of autoantibodies to oxidized low-density lipoprotein and hepatic steatosis in patients with chronic hepatitis C . Experimental and Therapeutic Medicine, 1, 663-668. https://doi.org/10.3892/etm_00000104
MLA
Himoto, T., Yoneyama, H., Deguchi, A., Kurokohchi, K., Inukai, M., Masugata, H., Goda, F., Senda, S., Haba, R., Watanabe, S., Nishioka, M., Masaki, T."Relationship between the production of autoantibodies to oxidized low-density lipoprotein and hepatic steatosis in patients with chronic hepatitis C ". Experimental and Therapeutic Medicine 1.4 (2010): 663-668.
Chicago
Himoto, T., Yoneyama, H., Deguchi, A., Kurokohchi, K., Inukai, M., Masugata, H., Goda, F., Senda, S., Haba, R., Watanabe, S., Nishioka, M., Masaki, T."Relationship between the production of autoantibodies to oxidized low-density lipoprotein and hepatic steatosis in patients with chronic hepatitis C ". Experimental and Therapeutic Medicine 1, no. 4 (2010): 663-668. https://doi.org/10.3892/etm_00000104
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