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Article

Association between polymorphisms of the DBH and DAT1 genes and attention deficit hyperactivity disorder in children from Jordan

  • Authors:
    • Mohammad Y. Gharaibeh
    • Sajida Batayneh
    • Omar F. Khabour
    • Azhar Daoud
  • View Affiliations / Copyright

    Affiliations: Department of Medical Laboratory Sciences, Jordan University of Science and Technology, Irbid 22110, Jordan. younisgh@just.edu.jo
  • Pages: 701-705
    |
    Published online on: July 1, 2010
       https://doi.org/10.3892/etm_00000108
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Abstract

Attention deficit hyperactivity disorder (ADHD) is one of the most common neuropsychiatric disorders in children. In this study, the association between 10-repeats in the DAT1 gene and the (GT)n repeat in the DBH gene and ADHD was examined in children from Jordan. In addition, the levels of dopamine-β-hydroxylase enzyme activity in the plasma of ADHD children were evaluated. Fifty children with ADHD and 50 age- and gender-matched control subjects were recruited. The results showed significant differences between the ADHD group and controls with respect to the plasma levels of dopamine-β-hydroxylase enzyme activity (25.4±2.3 vs. 84.7±5.0 µmol/min; p<0.01). Moreover, the 10-repeat DAT1 gene and (GT)n DBH gene polymorphisms were significantly associated with ADHD development (p<0.05). In conclusion, the DBH and DAT1 genes appear to play a role in the development of ADHD in the Jordanian population.
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Copy and paste a formatted citation
Spandidos Publications style
Gharaibeh MY, Batayneh S, Khabour OF and Daoud A: Association between polymorphisms of the DBH and DAT1 genes and attention deficit hyperactivity disorder in children from Jordan . Exp Ther Med 1: 701-705, 2010.
APA
Gharaibeh, M.Y., Batayneh, S., Khabour, O.F., & Daoud, A. (2010). Association between polymorphisms of the DBH and DAT1 genes and attention deficit hyperactivity disorder in children from Jordan . Experimental and Therapeutic Medicine, 1, 701-705. https://doi.org/10.3892/etm_00000108
MLA
Gharaibeh, M. Y., Batayneh, S., Khabour, O. F., Daoud, A."Association between polymorphisms of the DBH and DAT1 genes and attention deficit hyperactivity disorder in children from Jordan ". Experimental and Therapeutic Medicine 1.4 (2010): 701-705.
Chicago
Gharaibeh, M. Y., Batayneh, S., Khabour, O. F., Daoud, A."Association between polymorphisms of the DBH and DAT1 genes and attention deficit hyperactivity disorder in children from Jordan ". Experimental and Therapeutic Medicine 1, no. 4 (2010): 701-705. https://doi.org/10.3892/etm_00000108
Copy and paste a formatted citation
x
Spandidos Publications style
Gharaibeh MY, Batayneh S, Khabour OF and Daoud A: Association between polymorphisms of the DBH and DAT1 genes and attention deficit hyperactivity disorder in children from Jordan . Exp Ther Med 1: 701-705, 2010.
APA
Gharaibeh, M.Y., Batayneh, S., Khabour, O.F., & Daoud, A. (2010). Association between polymorphisms of the DBH and DAT1 genes and attention deficit hyperactivity disorder in children from Jordan . Experimental and Therapeutic Medicine, 1, 701-705. https://doi.org/10.3892/etm_00000108
MLA
Gharaibeh, M. Y., Batayneh, S., Khabour, O. F., Daoud, A."Association between polymorphisms of the DBH and DAT1 genes and attention deficit hyperactivity disorder in children from Jordan ". Experimental and Therapeutic Medicine 1.4 (2010): 701-705.
Chicago
Gharaibeh, M. Y., Batayneh, S., Khabour, O. F., Daoud, A."Association between polymorphisms of the DBH and DAT1 genes and attention deficit hyperactivity disorder in children from Jordan ". Experimental and Therapeutic Medicine 1, no. 4 (2010): 701-705. https://doi.org/10.3892/etm_00000108
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