Association between polymorphisms of the DBH and DAT1 genes and attention deficit hyperactivity disorder in children from Jordan

  • Authors:
    • Mohammad Y. Gharaibeh
    • Sajida Batayneh
    • Omar F. Khabour
    • Azhar Daoud
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  • Published online on: July 1, 2010     https://doi.org/10.3892/etm_00000108
  • Pages: 701-705
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Abstract

Attention deficit hyperactivity disorder (ADHD) is one of the most common neuropsychiatric disorders in children. In this study, the association between 10-repeats in the DAT1 gene and the (GT)n repeat in the DBH gene and ADHD was examined in children from Jordan. In addition, the levels of dopamine-β-hydroxylase enzyme activity in the plasma of ADHD children were evaluated. Fifty children with ADHD and 50 age- and gender-matched control subjects were recruited. The results showed significant differences between the ADHD group and controls with respect to the plasma levels of dopamine-β-hydroxylase enzyme activity (25.4±2.3 vs. 84.7±5.0 µmol/min; p<0.01). Moreover, the 10-repeat DAT1 gene and (GT)n DBH gene polymorphisms were significantly associated with ADHD development (p<0.05). In conclusion, the DBH and DAT1 genes appear to play a role in the development of ADHD in the Jordanian population.
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July-August 2010
Volume 1 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Gharaibeh MY, Batayneh S, Khabour OF and Daoud A: Association between polymorphisms of the DBH and DAT1 genes and attention deficit hyperactivity disorder in children from Jordan . Exp Ther Med 1: 701-705, 2010
APA
Gharaibeh, M.Y., Batayneh, S., Khabour, O.F., & Daoud, A. (2010). Association between polymorphisms of the DBH and DAT1 genes and attention deficit hyperactivity disorder in children from Jordan . Experimental and Therapeutic Medicine, 1, 701-705. https://doi.org/10.3892/etm_00000108
MLA
Gharaibeh, M. Y., Batayneh, S., Khabour, O. F., Daoud, A."Association between polymorphisms of the DBH and DAT1 genes and attention deficit hyperactivity disorder in children from Jordan ". Experimental and Therapeutic Medicine 1.4 (2010): 701-705.
Chicago
Gharaibeh, M. Y., Batayneh, S., Khabour, O. F., Daoud, A."Association between polymorphisms of the DBH and DAT1 genes and attention deficit hyperactivity disorder in children from Jordan ". Experimental and Therapeutic Medicine 1, no. 4 (2010): 701-705. https://doi.org/10.3892/etm_00000108