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Conserved functional motifs of the nuclear receptor superfamily as potential pharmacological targets

  • Authors:
    • Louis Papageorgiou
    • Livia Shalzi
    • Aspasia Efthimiadou
    • Flora Bacopoulou
    • George P. Chrousos
    • Elias Eliopoulos
    • Dimitrios Vlachakis
  • View Affiliations / Copyright

    Affiliations: Laboratory of Genetics, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, 11855 Athens, Greece, Department of Soil Science of Athens, Institute of Soil and Water Resources, Hellenic Agricultural Organization‑Demeter, 14123 Lycovrisi, Greece, University Research Institute of Maternal and Child Health and Precision Medicine, and UNESCO Chair on Adolescent Health Care, National and Kapodistrian University of Athens, ‘Aghia Sophia’ Children's Hospital, 11527 Athens, Greece
    Copyright: © Papageorgiou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 3
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    Published online on: June 2, 2021
       https://doi.org/10.3892/ije.2021.3
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Abstract

Nuclear receptors (NRs) are one of the most diverse and well-reported family of proteins. They are involved in numerous cellular processes as they play pivotal roles in cell signaling and the cell cycle. The participation of NRs in various applications in medicine and biology has greatly attracted the interest of the pharmaceutical industry for the discovery of novel and/or improved drugs for the treatment of several diseases, including cancer, diabetes or infertility. In the present study, in an effort to elucidate the molecular function of this superfamily and to identify novel pharmacological targets, a comprehensive sequence and structural analysis was performed using all available information from a repertoire of depositories. Functional conserved motifs were identified and analyzed with regards to their potential roles and implications in a number of biological processes. The essential differences among them were also addressed and discussed. In addition, these motifs were characterized in the main groups of the NRs, such as that of the steroid hormone receptors.
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Spandidos Publications style
Papageorgiou L, Shalzi L, Efthimiadou A, Bacopoulou F, Chrousos GP, Eliopoulos E and Vlachakis D: Conserved functional motifs of the nuclear receptor superfamily as potential pharmacological targets. Int J Epigen 1: 3, 2021.
APA
Papageorgiou, L., Shalzi, L., Efthimiadou, A., Bacopoulou, F., Chrousos, G.P., Eliopoulos, E., & Vlachakis, D. (2021). Conserved functional motifs of the nuclear receptor superfamily as potential pharmacological targets. International Journal of Epigenetics, 1, 3. https://doi.org/10.3892/ije.2021.3
MLA
Papageorgiou, L., Shalzi, L., Efthimiadou, A., Bacopoulou, F., Chrousos, G. P., Eliopoulos, E., Vlachakis, D."Conserved functional motifs of the nuclear receptor superfamily as potential pharmacological targets". International Journal of Epigenetics 1.2 (2021): 3.
Chicago
Papageorgiou, L., Shalzi, L., Efthimiadou, A., Bacopoulou, F., Chrousos, G. P., Eliopoulos, E., Vlachakis, D."Conserved functional motifs of the nuclear receptor superfamily as potential pharmacological targets". International Journal of Epigenetics 1, no. 2 (2021): 3. https://doi.org/10.3892/ije.2021.3
Copy and paste a formatted citation
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Spandidos Publications style
Papageorgiou L, Shalzi L, Efthimiadou A, Bacopoulou F, Chrousos GP, Eliopoulos E and Vlachakis D: Conserved functional motifs of the nuclear receptor superfamily as potential pharmacological targets. Int J Epigen 1: 3, 2021.
APA
Papageorgiou, L., Shalzi, L., Efthimiadou, A., Bacopoulou, F., Chrousos, G.P., Eliopoulos, E., & Vlachakis, D. (2021). Conserved functional motifs of the nuclear receptor superfamily as potential pharmacological targets. International Journal of Epigenetics, 1, 3. https://doi.org/10.3892/ije.2021.3
MLA
Papageorgiou, L., Shalzi, L., Efthimiadou, A., Bacopoulou, F., Chrousos, G. P., Eliopoulos, E., Vlachakis, D."Conserved functional motifs of the nuclear receptor superfamily as potential pharmacological targets". International Journal of Epigenetics 1.2 (2021): 3.
Chicago
Papageorgiou, L., Shalzi, L., Efthimiadou, A., Bacopoulou, F., Chrousos, G. P., Eliopoulos, E., Vlachakis, D."Conserved functional motifs of the nuclear receptor superfamily as potential pharmacological targets". International Journal of Epigenetics 1, no. 2 (2021): 3. https://doi.org/10.3892/ije.2021.3
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