Open Access

Conserved functional motifs of the nuclear receptor superfamily as potential pharmacological targets

  • Authors:
    • Louis Papageorgiou
    • Livia Shalzi
    • Aspasia Efthimiadou
    • Flora Bacopoulou
    • George P. Chrousos
    • Elias Eliopoulos
    • Dimitrios Vlachakis
  • View Affiliations

  • Published online on: June 2, 2021     https://doi.org/10.3892/ije.2021.3
  • Article Number: 3
  • Copyright: © Papageorgiou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Nuclear receptors (NRs) are one of the most diverse and well-reported family of proteins. They are involved in numerous cellular processes as they play pivotal roles in cell signaling and the cell cycle. The participation of NRs in various applications in medicine and biology has greatly attracted the interest of the pharmaceutical industry for the discovery of novel and/or improved drugs for the treatment of several diseases, including cancer, diabetes or infertility. In the present study, in an effort to elucidate the molecular function of this superfamily and to identify novel pharmacological targets, a comprehensive sequence and structural analysis was performed using all available information from a repertoire of depositories. Functional conserved motifs were identified and analyzed with regards to their potential roles and implications in a number of biological processes. The essential differences among them were also addressed and discussed. In addition, these motifs were characterized in the main groups of the NRs, such as that of the steroid hormone receptors.
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March-August 2021
Volume 1 Issue 2

Print ISSN: 2752-5406
Online ISSN:2752-5414

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Spandidos Publications style
Papageorgiou L, Shalzi L, Efthimiadou A, Bacopoulou F, Chrousos GP, Eliopoulos E and Vlachakis D: Conserved functional motifs of the nuclear receptor superfamily as potential pharmacological targets. Int J Epigen 1: 3, 2021
APA
Papageorgiou, L., Shalzi, L., Efthimiadou, A., Bacopoulou, F., Chrousos, G.P., Eliopoulos, E., & Vlachakis, D. (2021). Conserved functional motifs of the nuclear receptor superfamily as potential pharmacological targets. International Journal of Epigenetics, 1, 3. https://doi.org/10.3892/ije.2021.3
MLA
Papageorgiou, L., Shalzi, L., Efthimiadou, A., Bacopoulou, F., Chrousos, G. P., Eliopoulos, E., Vlachakis, D."Conserved functional motifs of the nuclear receptor superfamily as potential pharmacological targets". International Journal of Epigenetics 1.2 (2021): 3.
Chicago
Papageorgiou, L., Shalzi, L., Efthimiadou, A., Bacopoulou, F., Chrousos, G. P., Eliopoulos, E., Vlachakis, D."Conserved functional motifs of the nuclear receptor superfamily as potential pharmacological targets". International Journal of Epigenetics 1, no. 2 (2021): 3. https://doi.org/10.3892/ije.2021.3