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Review Open Access

Role of microRNAs as novel diagnostic biomarkers and potential therapeutic targets for hearing disorders (Review)

  • Authors:
    • Alessandro Lavoro
    • Giuseppe Gattuso
    • Caterina Maria Grillo
    • Demetrios A. Spandidos
    • Mario Salmeri
    • Cinzia Lombardo
    • Saverio Candido
    • Luca Falzone
  • View Affiliations / Copyright

    Affiliations: Department of Biomedical and Biotechnological Sciences, University of Catania, I‑95123 Catania, Italy, Department of Medical Sciences, Surgical and Advanced Technologies ‘GF Ingrassia’, University of Catania, I‑95123 Catania, Italy, Laboratory of Clinical Virology, Medical School, University of Crete, 71003 Heraklion, Greece
    Copyright: © Lavoro et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 3
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    Published online on: September 2, 2022
       https://doi.org/10.3892/ije.2022.12
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Abstract

The ear is a complex structure consisting of the outer, middle and inner ear. For the proper function of the auditory system, the development of all these parts needs to be highly organized. Any alterations in this chain of events can lead to hearing loss or other impairments, such as dizziness, tinnitus and loss of balance. Of note, several external and internal elements, including noise exposure, ototoxic drugs, aging, as well as environmental or genetic factors, have been widely associated with hearing loss. Over the years, a growing body of evidence has indicated that microRNAs (miRNAs/miRs) play a critical role in ear development and auditory function, suggesting that an altered pattern of miRNA expression may be involved in the progression of these pathological conditions. On these bases, the present review article aimed to summarize the role of miRNAs in inner ear development and hearing disorders. Although further studies are warranted to provide more in‑depth knowledge of the implicated mechanisms of action, according to the current data, miRNAs may be used as novel diagnostic biomarkers for the early detection of hearing loss. In addition, miRNAs and related signaling pathways may represent novel potential therapeutic targets for the treatment of hearing loss, ear inflammation and vestibular schwannoma.
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Copy and paste a formatted citation
Spandidos Publications style
Lavoro A, Gattuso G, Grillo CM, Spandidos DA, Salmeri M, Lombardo C, Candido S and Falzone L: Role of microRNAs as novel diagnostic biomarkers and potential therapeutic targets for hearing disorders (Review). Int J Epigen 2: 3, 2022.
APA
Lavoro, A., Gattuso, G., Grillo, C.M., Spandidos, D.A., Salmeri, M., Lombardo, C. ... Falzone, L. (2022). Role of microRNAs as novel diagnostic biomarkers and potential therapeutic targets for hearing disorders (Review). International Journal of Epigenetics, 2, 3. https://doi.org/10.3892/ije.2022.12
MLA
Lavoro, A., Gattuso, G., Grillo, C. M., Spandidos, D. A., Salmeri, M., Lombardo, C., Candido, S., Falzone, L."Role of microRNAs as novel diagnostic biomarkers and potential therapeutic targets for hearing disorders (Review)". International Journal of Epigenetics 2.3 (2022): 3.
Chicago
Lavoro, A., Gattuso, G., Grillo, C. M., Spandidos, D. A., Salmeri, M., Lombardo, C., Candido, S., Falzone, L."Role of microRNAs as novel diagnostic biomarkers and potential therapeutic targets for hearing disorders (Review)". International Journal of Epigenetics 2, no. 3 (2022): 3. https://doi.org/10.3892/ije.2022.12
Copy and paste a formatted citation
x
Spandidos Publications style
Lavoro A, Gattuso G, Grillo CM, Spandidos DA, Salmeri M, Lombardo C, Candido S and Falzone L: Role of microRNAs as novel diagnostic biomarkers and potential therapeutic targets for hearing disorders (Review). Int J Epigen 2: 3, 2022.
APA
Lavoro, A., Gattuso, G., Grillo, C.M., Spandidos, D.A., Salmeri, M., Lombardo, C. ... Falzone, L. (2022). Role of microRNAs as novel diagnostic biomarkers and potential therapeutic targets for hearing disorders (Review). International Journal of Epigenetics, 2, 3. https://doi.org/10.3892/ije.2022.12
MLA
Lavoro, A., Gattuso, G., Grillo, C. M., Spandidos, D. A., Salmeri, M., Lombardo, C., Candido, S., Falzone, L."Role of microRNAs as novel diagnostic biomarkers and potential therapeutic targets for hearing disorders (Review)". International Journal of Epigenetics 2.3 (2022): 3.
Chicago
Lavoro, A., Gattuso, G., Grillo, C. M., Spandidos, D. A., Salmeri, M., Lombardo, C., Candido, S., Falzone, L."Role of microRNAs as novel diagnostic biomarkers and potential therapeutic targets for hearing disorders (Review)". International Journal of Epigenetics 2, no. 3 (2022): 3. https://doi.org/10.3892/ije.2022.12
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