|
1
|
Wang D, Özen C, Abu-Reidah IM, Chigurupati S, Patra JK, Horbanczuk JO, Jóźwik A, Tzvetkov NT, Uhrin P and Atanasov AG: Vasculoprotective Effects of Pomegranate (Punica granatum L.). Front Pharmacol. 9(544)2018.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Guerrero-Solano JA, Jaramillo-Morales OA, Velázquez-González C, De la O-Arciniega M, Castañeda-Ovando A, Betanzos-Cabrera G and Bautista M: Pomegranate as a potential alternative of pain management: a review. Plants (Basel). 9(419)2020.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Wu S and Tian L: Diverse phytochemicals and bioactivities in the ancient fruit and modern functional food pomegranate (Punica granatum). Molecules. 22(1606)2017.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Sharma P, McClees SF and Afaq F: Pomegranate for prevention and treatment of cancer: an update. Molecules. 22(177)2017.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Jurenka JS: Therapeutic applications of pomegranate (Punica granatum L.): A review. Altern Med Rev. 13:128–144. 2008.PubMed/NCBI
|
|
6
|
Saeed M, Naveed M, BiBi J, Kamboh AA, Arain MA, Shah QA, Alagawany M, El-Hack MEA, Abdel-Latif MA, Yatoo MI, et al: The promising pharmacological effects and therapeutic/medicinal applications of Punica granatum L. (pomegranate) as a functional food in humans and animals. Recent Pat Inflamm Allergy Drug Discov. 12:24–38. 2018.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Tomás-Barberán FA and Espín JC: Effect of food structure and processing on (poly)phenol-gut microbiota interactions and the effects on human health. Annu Rev Food Sci Technol. 10:221–238. 2019.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Fischer UA, Carle R and Kammerer DR: Identification and quantification of phenolic compounds from pomegranate (Punica granatum L.) peel, mesocarp, aril and differently produced juices by HPLC-DAD-ESI/MS(n). Food Chem. 127:807–821. 2011.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Mena P, Calani L, Dall'Asta C, Galaverna G, García-Viguera C, Bruni R, Crozier A and Del Rio D: Rapid and comprehensive evaluation of (poly)phenolic compounds in pomegranate (Punica granatum L.) juice by UHPLC-MSn. Molecules. 17:14821–14840. 2012.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Ismail T, Sestili P and Akhtar S: Pomegranate peel and fruit extracts: A review of potential anti-inflammatory and anti-infective effects. J Ethnopharmacol. 143:397–405. 2012.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Shuid AN and Mohamed IN: Pomegranate use to attenuate bone loss in major musculoskeletal diseases: An evidence-based review. Curr Drug Targets. 14:1565–1578. 2013.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Turrini E, Ferruzzi L and Fimognari C: Potential effects of pomegranate polyphenols in cancer prevention and therapy. Oxid Med Cell Longev. 2015(938475)2015.PubMed/NCBI View Article : Google Scholar
|
|
13
|
Kalaycıoğlu Z and Erim FB: Total phenolic contents, antioxidant activities, and bioactive ingredients of juices from pomegranate cultivars worldwide. Food Chem. 221:496–507. 2017.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Danesi F and Ferguson LR: Could pomegranate juice help in the control of inflammatory diseases? Nutrients. 9(958)2017.PubMed/NCBI View Article : Google Scholar
|
|
15
|
Razani Z, Dastani M and Kazerani HR: Cardioprotective Effects of pomegranate (Punica granatum) juice in patients with ischemic heart disease. Phytother Res. 31:1731–1738. 2017.PubMed/NCBI View Article : Google Scholar
|
|
16
|
Viuda-Martos M, Fernández-López J and Pérez-Álvarez JA: Pomegranate and its many functional components as related to human health: A review. Compr Rev Food Sci Food Saf. 9:635–654. 2010.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Moga MA, Dimienescu OG, Bălan A, Dima L, Toma SI, Bîgiu NF and Blidaru A: Pharmacological and therapeutic properties of Punica granatum phytochemicals: possible roles in breast cancer. Molecules. 26(1054)2021.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Pirzadeh M, Caporaso N, Rauf A, Shariati MA, Yessimbekov Z, Khan MU, Imran M and Mubarak MS: Pomegranate as a source of bioactive constituents: A review on their characterization, properties and applications. Crit Rev Food Sci Nutr. 61:982–999. 2021.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Krueger DA: Composition of pomegranate juice. J AOAC Int. 95:163–168. 2012.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Fahmy H, Hegazi N, El-Shamy S and Farag MA: Pomegranate juice as a functional food: A comprehensive review of its polyphenols, therapeutic merits, and recent patents. Food Funct. 11:5768–5781. 2020.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Singh B, Singh JP, Kaur A and Singh N: Phenolic compounds as beneficial phytochemicals in pomegranate (Punica granatum L.) peel: A review. Food Chem. 261:75–86. 2018.PubMed/NCBI View Article : Google Scholar
|
|
22
|
El-Hadary AE and Ramadan MF: Phenolic profiles, antihyperglycemic, antihyperlipidemic, and antioxidant properties of pomegranate (Punica granatum) peel extract. J Food Biochem. 43(e12803)2019.PubMed/NCBI View Article : Google Scholar
|
|
23
|
Fourati M, Smaoui S, Hlima HB, Elhadef K, Braïek OB, Ennouri K, Mtibaa AC and Mellouli L: Bioactive compounds and pharmacological potential of pomegranate (Punica granatum) seeds - a review. Plant Foods Hum Nutr. 75:477–486. 2020.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Li G, Chen M, Chen J, Shang Y, Lian X, Wang P, Lei H and Ma Q: Chemical composition analysis of pomegranate seeds based on ultra-high-performance liquid chromatography coupled with quadrupole-Orbitrap high-resolution mass spectrometry. J Pharm Biomed Anal. 187(113357)2020.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Elfalleh W, Hannachi H, Tlili N, Yahia Y, Nasri N and Ferchichi A: Total phenolic content and antioxidant activities of pomegranate peel, seed, leaf and flower. J Med Plants Res. 6:4724–4730. 2012.
|
|
26
|
Sreedevi P, Vijayalakshmi K and Venkataeswari R: Phytochemical evaluation of Punica granatum L. leaf extract. Int J Curr Pharm Res. 9:14–18. 2017.
|
|
27
|
Di Stefano V, Pitonzo R, Novara ME, Bongiorno D, Indelicato S, Gentile C, Avellone G, Bognanni R, Scandurra S and Melilli MG: Antioxidant activity and phenolic composition in pomegranate (Punica granatum L.) genotypes from south Italy by UHPLC-Orbitrap-MS approach. J Sci Food Agric. 99:1038–1045. 2019.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Russo M, Fanali C, Tripodo G, Dugo P, Muleo R, Dugo L, De Gara L and Mondello L: Analysis of phenolic compounds in different parts of pomegranate (Punica granatum) fruit by HPLC-PDA-ESI/MS and evaluation of their antioxidant activity: Application to different Italian varieties. Anal Bioanal Chem. 410:3507–3520. 2018.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Seeram NP, Adams LS, Henning SM, Niu Y, Zhang Y, Nair MG and Heber D: In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. J Nutr Biochem. 16:360–367. 2005.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Johanningsmeier SD and Harris GK: Pomegranate as a functional food and nutraceutical source. Annu Rev Food Sci Technol. 2:181–201. 2011.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Hussain T, Tan B, Yin Y, Blachier F, Tossou MC and Rahu N: Oxidative stress and inflammation: what polyphenols can do for us? Oxid Med Cell Longev. 2016(7432797)2016.PubMed/NCBI View Article : Google Scholar
|
|
32
|
Rozenberg O, Howell A and Aviram M: Pomegranate juice sugar fraction reduces macrophage oxidative state, whereas white grape juice sugar fraction increases it. Atherosclerosis. 188:68–76. 2006.PubMed/NCBI View Article : Google Scholar
|
|
33
|
Seeram NP, Aviram M, Zhang Y, Henning SM, Feng L, Dreher M and Heber D: Comparison of antioxidant potency of commonly consumed polyphenol-rich beverages in the United States. J Agric Food Chem. 56:1415–1422. 2008.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Gómez-Caravaca AM, Verardo V, Toselli M, Segura-Carretero A, Fernández-Gutiérrez A and Caboni MF: Determination of the major phenolic compounds in pomegranate juices by HPLC-DAD-ESI-MS. J Agric Food Chem. 61:5328–5337. 2013.PubMed/NCBI View Article : Google Scholar
|
|
35
|
Derakhshan Z, Ferrante M, Tadi M, Ansari F, Heydari A, Hosseini MS, Conti GO and Sadrabad EK: Antioxidant activity and total phenolic content of ethanolic extract of pomegranate peels, juice and seeds. Food Chem Toxicol. 114:108–111. 2018.PubMed/NCBI View Article : Google Scholar
|
|
36
|
Tugcu B, Nacaroglu SA, Gedikbasi A, Uhri M, Acar N and Ozdemir H: Protective effect of pomegranate juice on retinal oxidative stress in streptozotocin-induced diabetic rats. Int J Ophthalmol. 10:1662–1668. 2017.PubMed/NCBI View Article : Google Scholar
|
|
37
|
Liu C, Guo H, DaSilva NA, Li D, Zhang K, Wan Y, Gao XH, Chen HD, Seeram NP and Ma H: Pomegranate (Punica granatum) phenolics ameliorate hydrogen peroxide-induced oxidative stress and cytotoxicity in human keratinocytes. J Funct Foods. 54:559–567. 2019.
|
|
38
|
Morittu VM, Mastellone V, Tundis R, Loizzo MR, Tudisco R, Figoli A, Cassano A, Musco N, Britti D, Infascelli F, et al: Antioxidant, biochemical, and in-life effects of Punica granatum L. natural juice vs. clarified juice by polyvinylidene fluoride membrane. Foods. 9(242)2020.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Lin Y, Jiang M, Chen W, Zhao T and Wei Y: Cancer and ER stress: Mutual crosstalk between autophagy, oxidative stress and inflammatory response. Biomed Pharmacother. 118(109249)2019.PubMed/NCBI View Article : Google Scholar
|
|
40
|
Ahmadi A, Polyak S and Draganov PV: Colorectal cancer surveillance in inflammatory bowel disease: The search continues. World J Gastroenterol. 15:61–66. 2009.PubMed/NCBI View Article : Google Scholar
|
|
41
|
Nasef NA, Mehta S and Ferguson LR: Susceptibility to chronic inflammation: An update. Arch Toxicol. 91:1131–1141. 2017.PubMed/NCBI View Article : Google Scholar
|
|
42
|
Calder PC, Albers R, Antoine JM, Blum S, Bourdet-Sicard R, Ferns GA, Folkerts G, Friedmann PS, Frost GS, Guarner F, et al: Inflammatory disease processes and interactions with nutrition. Br J Nutr. 101 (Suppl 1):S1–S45. 2009.PubMed/NCBI View Article : Google Scholar
|
|
43
|
Zhao CN, Meng X, Li Y, Li S, Liu Q, Tang GY and Li HB: Fruits for prevention and treatment of cardiovascular diseases. Nutrients. 9(598)2017.PubMed/NCBI View Article : Google Scholar
|
|
44
|
Salas-Salvadó J, Becerra-Tomás N, García-Gavilán JF, Bulló M and Barrubés L: Mediterranean diet and cardiovascular disease prevention: what do we know? Prog Cardiovasc Dis. 61:62–67. 2018.PubMed/NCBI View Article : Google Scholar
|
|
45
|
Davinelli S, Maes M, Corbi G, Zarrelli A, Willcox DC and Scapagnini G: Dietary phytochemicals and neuro-inflammaging: From mechanistic insights to translational challenges. Immun Ageing. 13(16)2016.PubMed/NCBI View Article : Google Scholar
|
|
46
|
Serino A and Salazar G: Protective role of polyphenols against vascular inflammation, aging and cardiovascular disease. Nutrients. 11(53)2018.PubMed/NCBI View Article : Google Scholar
|
|
47
|
Du L, Li J, Zhang X, Wang L and Zhang W: Pomegranate peel polyphenols inhibits inflammation in LPS-induced RAW264.7 macrophages via the suppression of MAPKs activation. J Funct Foods. 43:62–69. 2018.PubMed/NCBI View Article : Google Scholar
|
|
48
|
Mastrogiovanni F, Mukhopadhya A, Lacetera N, Ryan MT, Romani A, Bernini R and Sweeney T: Anti-inflammatory effects of pomegranate peel extracts on in vitro human intestinal Caco-2 cells and ex vivo porcine colonic tissue explants. Nutrients. 11(548)2019.PubMed/NCBI View Article : Google Scholar
|
|
49
|
Pepe G, Rapa SF, Salviati E, Bertamino A, Auriemma G, Cascioferro S, Autore G, Quaroni A, Campiglia P and Marzocco S: Bioactive polyphenols from pomegranate juice reduce 5-fluorouracil-induced intestinal mucositis in intestinal epithelial cells. Antioxidants. 9(699)2020.PubMed/NCBI View Article : Google Scholar
|
|
50
|
Rose MR: Adaptation, aging, and genomic information. Aging (Albany NY). 1:444–450. 2009.PubMed/NCBI View Article : Google Scholar
|
|
51
|
Johnson IP: Age-related neurodegenerative disease research needs aging models. Front Aging Neurosci. 7(168)2015.PubMed/NCBI View Article : Google Scholar
|
|
52
|
Khosla S, Farr JN and Kirkland JL: Inhibiting cellular senescence: a new therapeutic paradigm for age-related osteoporosis. J Clin Endocrinol Metab. 103:1282–1290. 2018.PubMed/NCBI View Article : Google Scholar
|
|
53
|
Brettschneider J, Del Tredici K, Lee VM and Trojanowski JQ: Spreading of pathology in neurodegenerative diseases: A focus on human studies. Nat Rev Neurosci. 16:109–120. 2015.PubMed/NCBI View Article : Google Scholar
|
|
54
|
Kovacs GG: Molecular pathology of neurodegenerative diseases: Principles and practice. J Clin Pathol. 72:725–735. 2019.PubMed/NCBI View Article : Google Scholar
|
|
55
|
Braidy N, Essa MM, Poljak A, Selvaraju S, Al-Adawi S, Manivasagm T, Thenmozhi AJ, Ooi L, Sachdev P and Guillemin GJ: Consumption of pomegranates improves synaptic function in a transgenic mice model of Alzheimer's disease. Oncotarget. 7:64589–64604. 2016.PubMed/NCBI View Article : Google Scholar
|
|
56
|
Kujawska M, Jourdes M, Kurpik M, Szulc M, Szaefer H, Chmielarz P, Kreiner G, Krajka-Kuźniak V, Mikołajczak PŁ, Teissedre PL, et al: Neuroprotective effects of pomegranate juice against parkinson's disease and presence of ellagitannins-derived metabolite-urolithin a-in the brain. Int J Mol Sci. 21(202)2019.PubMed/NCBI View Article : Google Scholar
|
|
57
|
Lock CA, Lecouturier J, Mason JM and Dickinson HO: Lifestyle interventions to prevent osteoporotic fractures: A systematic review. Osteoporos Int. 17:20–28. 2006.PubMed/NCBI View Article : Google Scholar
|
|
58
|
Sandhu SK and Hampson G: The pathogenesis, diagnosis, investigation and management of osteoporosis. J Clin Pathol. 64:1042–1050. 2011.PubMed/NCBI View Article : Google Scholar
|
|
59
|
Harvey N, Dennison E and Cooper C: Osteoporosis: Impact on health and economics. Nat Rev Rheumatol. 6:99–105. 2010.PubMed/NCBI View Article : Google Scholar
|
|
60
|
Schulman RC, Weiss AJ and Mechanick JI: Nutrition, bone, and aging: An integrative physiology approach. Curr Osteoporos Rep. 9:184–195. 2011.PubMed/NCBI View Article : Google Scholar
|
|
61
|
Spilmont M, Léotoing L, Davicco MJ, Lebecque P, Mercier S, Miot-Noirault E, Pilet P, Rios L, Wittrant Y and Coxam V: Pomegranate and its derivatives can improve bone health through decreased inflammation and oxidative stress in an animal model of postmenopausal osteoporosis. Eur J Nutr. 53:1155–1164. 2014.PubMed/NCBI View Article : Google Scholar
|
|
62
|
Wang W, Bai J, Zhang W, Ge G, Wang Q, Liang X, Li N, Gu Y, Li M, Xu W, et al: Protective effects of punicalagin on osteoporosis by inhibiting osteoclastogenesis and inflammation via the nf-κb and mapk pathways. Front Pharmacol. 11(696)2020.PubMed/NCBI View Article : Google Scholar
|
|
63
|
Eaton CB: Traditional and emerging risk factors for cardiovascular disease. Prim Care. 32:963–976, vii. 2005.PubMed/NCBI View Article : Google Scholar
|
|
64
|
Jagannathan R, Patel SA, Ali MK and Narayan KMV: Global updates on cardiovascular disease mortality trends and attribution of traditional risk factors. Curr Diab Rep. 19(44)2019.PubMed/NCBI View Article : Google Scholar
|
|
65
|
Eilat-Adar S, Sinai T, Yosefy C and Henkin Y: Nutritional recommendations for cardiovascular disease prevention. Nutrients. 5:3646–3683. 2013.PubMed/NCBI View Article : Google Scholar
|
|
66
|
Wang X, Ouyang Y, Liu J, Zhu M, Zhao G, Bao W and Hu FB: Fruit and vegetable consumption and mortality from all causes, cardiovascular disease, and cancer: Systematic review and dose-response meta-analysis of prospective cohort studies. BMJ. 349(g4490)2014.PubMed/NCBI View Article : Google Scholar
|
|
67
|
Chong MF, Macdonald R and Lovegrove JA: Fruit polyphenols and CVD risk: A review of human intervention studies. Br J Nutr. 104 (Suppl 3):S28–S39. 2010.PubMed/NCBI View Article : Google Scholar
|
|
68
|
Grassi D, Desideri G and Ferri C: Flavonoids: Antioxidants against atherosclerosis. Nutrients. 2:889–902. 2010.PubMed/NCBI View Article : Google Scholar
|
|
69
|
Stockton A, Farhat G, McDougall GJ and Al-Dujaili EAS: Effect of pomegranate extract on blood pressure and anthropometry in adults: A double-blind placebo-controlled randomised clinical trial. J Nutr Sci. 6(e39)2017.PubMed/NCBI View Article : Google Scholar
|
|
70
|
Estrada-Luna D, Martínez-Hinojosa E, Cancino-Diaz JC, Belefant-Miller H, López-Rodríguez G and Betanzos-Cabrera G: Daily supplementation with fresh pomegranate juice increases paraoxonase 1 expression and activity in mice fed a high-fat diet. Eur J Nutr. 57:383–389. 2018.PubMed/NCBI View Article : Google Scholar
|
|
71
|
Gaidukov L and Tawfik DS: High affinity, stability, and lactonase activity of serum paraoxonase PON1 anchored on HDL with ApoA-I. Biochemistry. 44:11843–11854. 2005.PubMed/NCBI View Article : Google Scholar
|
|
72
|
Gouédard C, Barouki R and Morel Y: Dietary polyphenols increase paraoxonase 1 gene expression by an aryl hydrocarbon receptor-dependent mechanism. Mol Cell Biol. 24:5209–5222. 2004.PubMed/NCBI View Article : Google Scholar
|
|
73
|
Huang TH, Peng G, Kota BP, Li GQ, Yamahara J, Roufogalis BD and Li Y: Pomegranate flower improves cardiac lipid metabolism in a diabetic rat model: Role of lowering circulating lipids. Br J Pharmacol. 145:767–774. 2005.PubMed/NCBI View Article : Google Scholar
|
|
74
|
Bagri P, Ali M, Aeri V, Bhowmik M and Sultana S: Antidiabetic effect of Punica granatum flowers: Effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes. Food Chem Toxicol. 47:50–54. 2009.PubMed/NCBI View Article : Google Scholar
|
|
75
|
Les F, Arbonés-Mainar JM, Valero MS and López V: Pomegranate polyphenols and urolithin A inhibit α-glucosidase, dipeptidyl peptidase-4, lipase, triglyceride accumulation and adipogenesis related genes in 3T3-L1 adipocyte-like cells. J Ethnopharmacol. 220:67–74. 2018.PubMed/NCBI View Article : Google Scholar
|
|
76
|
Blaut M and Clavel T: Metabolic diversity of the intestinal microbiota: Implications for health and disease. J Nutr. 137 (Suppl 2):751S–755S. 2007.PubMed/NCBI View Article : Google Scholar
|
|
77
|
Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C, Nielsen T, Pons N, Levenez F, Yamada T, et al: MetaHIT Consortium: A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 464:59–65. 2010.PubMed/NCBI View Article : Google Scholar
|
|
78
|
Belkaid Y and Hand TW: Role of the microbiota in immunity and inflammation. Cell. 157:121–141. 2014.PubMed/NCBI View Article : Google Scholar
|
|
79
|
Cani PD, Osto M, Geurts L and Everard A: Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity. Gut Microbes. 3:279–288. 2012.PubMed/NCBI View Article : Google Scholar
|
|
80
|
Karlsson F, Tremaroli V, Nielsen J and Bäckhed F: Assessing the human gut microbiota in metabolic diseases. Diabetes. 62:3341–3349. 2013.PubMed/NCBI View Article : Google Scholar
|
|
81
|
Scott KP, Antoine JM, Midtvedt T and van Hemert S: Manipulating the gut microbiota to maintain health and treat disease. Microb Ecol Health Dis. 26(25877)2015.PubMed/NCBI View Article : Google Scholar
|
|
82
|
Dueñas M, Muñoz-González I, Cueva C, Jiménez-Girón A, Sánchez-Patán F, Santos-Buelga C, Moreno-Arribas MV and Bartolomé B: A survey of modulation of gut microbiota by dietary polyphenols. BioMed Res Int. 2015(850902)2015.PubMed/NCBI View Article : Google Scholar
|
|
83
|
Holscher HD: Dietary fiber and prebiotics and the gastrointestinal microbiota. Gut Microbes. 8:172–184. 2017.PubMed/NCBI View Article : Google Scholar
|
|
84
|
Bialonska D, Kasimsetty SG, Schrader KK and Ferreira D: The effect of pomegranate (Punica granatum L.) byproducts and ellagitannins on the growth of human gut bacteria. J Agric Food Chem. 57:8344–8349. 2009.PubMed/NCBI View Article : Google Scholar
|
|
85
|
Finegold SM, Summanen PH, Corbett K, Downes J, Henning SM and Li Z: Pomegranate extract exhibits in vitro activity against Clostridium difficile. Nutrition. 30:1210–1212. 2014.PubMed/NCBI View Article : Google Scholar
|
|
86
|
Li Z, Summanen PH, Komoriya T, Henning SM, Lee RP, Carlson E, Heber D and Finegold SM: Pomegranate ellagitannins stimulate growth of gut bacteria in vitro: Implications for prebiotic and metabolic effects. Anaerobe. 34:164–168. 2015.PubMed/NCBI View Article : Google Scholar
|
|
87
|
González-Sarrías A, Romo-Vaquero M, García-Villalba R, Cortés-Martín A, Selma MV and Espín JC: The endotoxemia marker lipopolysaccharide-binding protein is reduced in overweight-obese subjects consuming pomegranate extract by modulating the gut microbiota: a randomized clinical trial. Mol Nutr Food Res. 62(e1800160)2018.PubMed/NCBI View Article : Google Scholar
|
|
88
|
Zhao R, Long X, Yang J, Du L, Zhang X, Li J and Hou C: Pomegranate peel polyphenols reduce chronic low-grade inflammatory responses by modulating gut microbiota and decreasing colonic tissue damage in rats fed a high-fat diet. Food Funct. 10:8273–8285. 2019.PubMed/NCBI View Article : Google Scholar
|
|
89
|
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin: Feb 4, 2021 (Epub ahead of print).
|
|
90
|
Vasan N, Baselga J and Hyman DM: A view on drug resistance in cancer. Nature. 575:299–309. 2019.PubMed/NCBI View Article : Google Scholar
|
|
91
|
Barnard RJ: Prevention of cancer through lifestyle changes. Evid Based Complement Alternat Med. 1:233–239. 2004.PubMed/NCBI View Article : Google Scholar
|
|
92
|
Key TJ, Schatzkin A, Willett WC, Allen NE, Spencer EA and Travis RC: Diet, nutrition and the prevention of cancer. Public Health Nutr. 7 (1A):187–200. 2004.PubMed/NCBI View Article : Google Scholar
|
|
93
|
Turati F, Rossi M, Pelucchi C, Levi F and La Vecchia C: Fruit and vegetables and cancer risk: A review of southern European studies. Br J Nutr. 113 (Suppl 2):S102–S110. 2015.PubMed/NCBI View Article : Google Scholar
|
|
94
|
Khan N, Afaq F and Mukhtar H: Cancer chemoprevention through dietary antioxidants: Progress and promise. Antioxid Redox Signal. 10:475–510. 2008.PubMed/NCBI View Article : Google Scholar
|
|
95
|
Faria A and Calhau C: The bioactivity of pomegranate: Impact on health and disease. Crit Rev Food Sci Nutr. 51:626–634. 2011.PubMed/NCBI View Article : Google Scholar
|
|
96
|
Kandylis P and Kokkinomagoulos E: Food applications and potential health benefits of pomegranate and its derivatives. Foods. 9(122)2020.PubMed/NCBI View Article : Google Scholar
|
|
97
|
Mandal A and Bishayee A: Mechanism of breast cancer preventive action of pomegranate: disruption of estrogen receptor and Wnt/β-catenin signaling pathways. Molecules. 20:22315–22328. 2015.PubMed/NCBI View Article : Google Scholar
|
|
98
|
Li Y, Yang F, Zheng W, Hu M, Wang J, Ma S, Deng Y, Luo Y, Ye T and Yin W: Punica granatum (pomegranate) leaves extract induces apoptosis through mitochondrial intrinsic pathway and inhibits migration and invasion in non-small cell lung cancer in vitro. Biomed Pharmacother. 80:227–235. 2016.PubMed/NCBI View Article : Google Scholar
|
|
99
|
Deng Y, Li Y, Yang F, Zeng A, Yang S, Luo Y, Zhang Y, Xie Y, Ye T, Xia Y, et al: The extract from Punica granatum (pomegranate) peel induces apoptosis and impairs metastasis in prostate cancer cells. Biomed Pharmacother. 93:976–984. 2017.PubMed/NCBI View Article : Google Scholar
|
|
100
|
Ganesan T, Sinniah A, Chik Z and Alshawsh MA: Punicalagin regulates apoptosis-autophagy switch via modulation of annexin A1 in colorectal cancer. Nutrients. 12(2430)2020.PubMed/NCBI View Article : Google Scholar
|
