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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2002 Volume 10 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2002 Volume 10 Issue 4

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Article

Expression and regulation of WNT10B in human cancer: Up-regulation of WNT10B in MCF-7 cells by β-estradiol and down-regulation of WNT10B in NT2 cells by retinoic acid

  • Authors:
    • Hiroyuki Kirikoshi
    • Masaru Katoh

  • View Affiliations / Copyright

    Affiliations: Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tokyo 104-0045, Japan
  • Pages: 507-511
    |
    Published online on: October 1, 2002
       https://doi.org/10.3892/ijmm.10.4.507
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Abstract

WNT signaling molecules, playing key roles in embryogenesis and carcinogenesis, are potent targets for regenerative medicine and clinical oncology. We have previously cloned and characterized the human orthologue of mouse proto-oncogene Wnt-10b using bioinformatics and cDNA-PCR. Human WNT10B is moderately expressed in MKN45 and MKN74 cells derived from human gastric cancer, and is up-regulated by tumor necrosis factor α (TNFα) in MKN45 cells. Here, expression and regulation of WNT10B in human cancer other than gastric cancer were investigated using cDNA-PCR. WNT10B mRNA was expressed in the majority of squamous cell carcinoma cell lines derived from esophageal cancer and cervical cancer. WNT10B mRNA was relatively highly expressed in TE3, TE6, TE10, TE11 (esophageal cancer), Hs700T (pancreatic cancer), SKG-IIIa, HeLa S3 (cervical cancer), and T-47D (breast cancer). Expression of WNT10B mRNA was up-regulated by β-estradiol in MCF-7 cells expressing estrogen receptors. Expression of WNT10B mRNA was down-regulated by all-trans retinoic acid in NT2 cells with the potential of self renewal and neuronal differentiation. WNT10B might be implicated in self renewal of stem cells as well as in carcinogenesis through activation of the WNT - β-catenin pathway.

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Copy and paste a formatted citation
Spandidos Publications style
Kirikoshi H and Katoh M: Expression and regulation of WNT10B in human cancer: Up-regulation of WNT10B in MCF-7 cells by β-estradiol and down-regulation of WNT10B in NT2 cells by retinoic acid. Int J Mol Med 10: 507-511, 2002.
APA
Kirikoshi, H., & Katoh, M. (2002). Expression and regulation of WNT10B in human cancer: Up-regulation of WNT10B in MCF-7 cells by β-estradiol and down-regulation of WNT10B in NT2 cells by retinoic acid. International Journal of Molecular Medicine, 10, 507-511. https://doi.org/10.3892/ijmm.10.4.507
MLA
Kirikoshi, H., Katoh, M."Expression and regulation of WNT10B in human cancer: Up-regulation of WNT10B in MCF-7 cells by β-estradiol and down-regulation of WNT10B in NT2 cells by retinoic acid". International Journal of Molecular Medicine 10.4 (2002): 507-511.
Chicago
Kirikoshi, H., Katoh, M."Expression and regulation of WNT10B in human cancer: Up-regulation of WNT10B in MCF-7 cells by β-estradiol and down-regulation of WNT10B in NT2 cells by retinoic acid". International Journal of Molecular Medicine 10, no. 4 (2002): 507-511. https://doi.org/10.3892/ijmm.10.4.507
Copy and paste a formatted citation
x
Spandidos Publications style
Kirikoshi H and Katoh M: Expression and regulation of WNT10B in human cancer: Up-regulation of WNT10B in MCF-7 cells by β-estradiol and down-regulation of WNT10B in NT2 cells by retinoic acid. Int J Mol Med 10: 507-511, 2002.
APA
Kirikoshi, H., & Katoh, M. (2002). Expression and regulation of WNT10B in human cancer: Up-regulation of WNT10B in MCF-7 cells by β-estradiol and down-regulation of WNT10B in NT2 cells by retinoic acid. International Journal of Molecular Medicine, 10, 507-511. https://doi.org/10.3892/ijmm.10.4.507
MLA
Kirikoshi, H., Katoh, M."Expression and regulation of WNT10B in human cancer: Up-regulation of WNT10B in MCF-7 cells by β-estradiol and down-regulation of WNT10B in NT2 cells by retinoic acid". International Journal of Molecular Medicine 10.4 (2002): 507-511.
Chicago
Kirikoshi, H., Katoh, M."Expression and regulation of WNT10B in human cancer: Up-regulation of WNT10B in MCF-7 cells by β-estradiol and down-regulation of WNT10B in NT2 cells by retinoic acid". International Journal of Molecular Medicine 10, no. 4 (2002): 507-511. https://doi.org/10.3892/ijmm.10.4.507
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