Effect of red wine and wine polyphenol resveratrol on endothelial function in hypercholesterolemic rabbits

  • Authors:
    • Jian-Gang Zou
    • Zhi-Rong Wang
    • Yuan-Zhu Huang
    • Ke-Jiang Cao
    • Joseph M. Wu
  • View Affiliations

  • Published online on: March 1, 2003     https://doi.org/10.3892/ijmm.11.3.317
  • Pages: 317-320
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Abstract

The effect of red wine and wine polyphenol resveratrol on endothelial function was investigated in experimental hypercholesterolemic rabbits. Endothelial function as measured by flow-mediated dilation (FMD) in the femoral artery was 19.28±2.81% in control animals fed a regular diet. In contrast, rabbits fed a high-cholesterol (1.5%) diet showed a reduced endothelial function, as revealed by a 25% reduction in the measured FMD. Intragastric feeding of resveratrol (3 mg/kg/day), red wine (4 ml/kg/day), dealcoholized red wine (4 ml/kg/day), for 12 weeks in hypercholesterolemic rabbits significantly mitigated the reduction in endothelial function, and resulted in FMD values of 14.52±0.60, 18.95±2.30, 17.58±1.43, and 18.80±3.94%, respectively. Measurement of plasma endothelin 1 (ET-1) and nitric oxide (NO) levels showed that feeding a high-cholesterol diet significantly increased plasma ET-1 levels (from 51.4±17.6 to 96.9±24.3 pg/ml), and decreased plasma NO concentration (from 104.6±18.5 to 67.7±16.1 pg/ml). With administration of resveratrol, red wine, or dealcoholized red wine, plasma ET-1 levels statistically decreased, in parallel with a significant elevation in NO levels. These results provide in vivo evidence suggesting that resveratrol and red wine improve endothelial function, which may be one of the mechanisms by which this red wine polyphenol exerts its alcohol-independent cardioprotective effects.

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March 2003
Volume 11 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Zou J, Wang Z, Huang Y, Cao K and Wu JM: Effect of red wine and wine polyphenol resveratrol on endothelial function in hypercholesterolemic rabbits. Int J Mol Med 11: 317-320, 2003.
APA
Zou, J., Wang, Z., Huang, Y., Cao, K., & Wu, J.M. (2003). Effect of red wine and wine polyphenol resveratrol on endothelial function in hypercholesterolemic rabbits. International Journal of Molecular Medicine, 11, 317-320. https://doi.org/10.3892/ijmm.11.3.317
MLA
Zou, J., Wang, Z., Huang, Y., Cao, K., Wu, J. M."Effect of red wine and wine polyphenol resveratrol on endothelial function in hypercholesterolemic rabbits". International Journal of Molecular Medicine 11.3 (2003): 317-320.
Chicago
Zou, J., Wang, Z., Huang, Y., Cao, K., Wu, J. M."Effect of red wine and wine polyphenol resveratrol on endothelial function in hypercholesterolemic rabbits". International Journal of Molecular Medicine 11, no. 3 (2003): 317-320. https://doi.org/10.3892/ijmm.11.3.317