Deciphering the impaired cytokine cascades in chronic leg ulcers (Review)

  • Authors:
    • Pascale Quatresooz
    • Frédérique Henry
    • Philippe Paquet
    • Claudine Pierard-Franchimont
    • Keith Harding
    • Gérald E. Pierard
  • View Affiliations

  • Published online on: April 1, 2003     https://doi.org/10.3892/ijmm.11.4.411
  • Pages: 411-418
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Abstract

Chronic leg ulcers are typically wounds that do not heal at a normal rate. Impaired healing appears to be due to primary microvascular changes and it is aggravated by ongoing bacteria-driven vasculitis. The various cytokines identified in experimental wounds are also present in leg ulcers. VEGF is strongly implicated as a promoter of blood vessel growth in patients with venous disease. In addition, there is good evidence of increased expression of bFGF, TGF-β1, and PDGF in lipodermatosclerosis. All of these growth factors are involved in wound healing. Upregulated TGF-β1 is probably one of the main causes of the fibrosis observed in lipodermatosclerosis. In leg ulcers, cytokines appear to be trapped in the perivascular fibrinoid deposits. It is not the nature and amount of cytokines that are inadequate in leg ulcers, but rather their spatial distribution. Dermal dendrocytes (DD) are resident factor XIIIa-enriched macrophages. They likely play a role in tissue repair when boosted adequately. New therapies aiming at helping the release of cytokines by DD apparently promote and improve the healing phase.

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April 2003
Volume 11 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Quatresooz P, Henry F, Paquet P, Pierard-Franchimont C, Harding K and Pierard GE: Deciphering the impaired cytokine cascades in chronic leg ulcers (Review). Int J Mol Med 11: 411-418, 2003.
APA
Quatresooz, P., Henry, F., Paquet, P., Pierard-Franchimont, C., Harding, K., & Pierard, G.E. (2003). Deciphering the impaired cytokine cascades in chronic leg ulcers (Review). International Journal of Molecular Medicine, 11, 411-418. https://doi.org/10.3892/ijmm.11.4.411
MLA
Quatresooz, P., Henry, F., Paquet, P., Pierard-Franchimont, C., Harding, K., Pierard, G. E."Deciphering the impaired cytokine cascades in chronic leg ulcers (Review)". International Journal of Molecular Medicine 11.4 (2003): 411-418.
Chicago
Quatresooz, P., Henry, F., Paquet, P., Pierard-Franchimont, C., Harding, K., Pierard, G. E."Deciphering the impaired cytokine cascades in chronic leg ulcers (Review)". International Journal of Molecular Medicine 11, no. 4 (2003): 411-418. https://doi.org/10.3892/ijmm.11.4.411