The HIP gene encoding a heparin/heparan sulfate interacting protein is mutated in metastatic human colorectal cancer

  • Authors:
    • Yuxun Wang
    • Sandra Tan
    • Shing Chuan Hooi
  • View Affiliations

  • Published online on: April 1, 2003     https://doi.org/10.3892/ijmm.11.4.473
  • Pages: 473-477
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Abstract

Heparin/heparan sulfate interacting protein (HIP) was initially identified as an adhesion molecule from a human uterine epithelial cell line. It was previously demonstrated that HIP was upregulated in human colorectal cancer. However, its expression was significantly lower in Dukes' D samples compared to earlier Dukes' stagesEsuggesting that HIP was inversely correlated to metastasis. The present study shows the presence of mutations in human metastatic colorectal cancer tissue and a cell line. Interestingly, a 12-base deletion encoding the heparin/heparan sulfate binding motif was common between the metastatic tissue and cell line. There was no mutation in the primary carcinoma and normal tissue. The findings suggest an important role for HIP in colorectal cancer metastasis.

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April 2003
Volume 11 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Wang Y, Tan S and Hooi SC: The HIP gene encoding a heparin/heparan sulfate interacting protein is mutated in metastatic human colorectal cancer. Int J Mol Med 11: 473-477, 2003.
APA
Wang, Y., Tan, S., & Hooi, S.C. (2003). The HIP gene encoding a heparin/heparan sulfate interacting protein is mutated in metastatic human colorectal cancer. International Journal of Molecular Medicine, 11, 473-477. https://doi.org/10.3892/ijmm.11.4.473
MLA
Wang, Y., Tan, S., Hooi, S. C."The HIP gene encoding a heparin/heparan sulfate interacting protein is mutated in metastatic human colorectal cancer". International Journal of Molecular Medicine 11.4 (2003): 473-477.
Chicago
Wang, Y., Tan, S., Hooi, S. C."The HIP gene encoding a heparin/heparan sulfate interacting protein is mutated in metastatic human colorectal cancer". International Journal of Molecular Medicine 11, no. 4 (2003): 473-477. https://doi.org/10.3892/ijmm.11.4.473