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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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April 2003 Volume 11 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

The HIP gene encoding a heparin/heparan sulfate interacting protein is mutated in metastatic human colorectal cancer

  • Authors:
    • Yuxun Wang
    • Sandra Tan
    • Shing Chuan Hooi

  • View Affiliations / Copyright

    Affiliations: Department of Physiology, Faculty of Medicine, National University of Singapore, Singapore 117597, Republic of Singapore
  • Pages: 473-477
    |
    Published online on: April 1, 2003
       https://doi.org/10.3892/ijmm.11.4.473
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Abstract

Heparin/heparan sulfate interacting protein (HIP) was initially identified as an adhesion molecule from a human uterine epithelial cell line. It was previously demonstrated that HIP was upregulated in human colorectal cancer. However, its expression was significantly lower in Dukes' D samples compared to earlier Dukes' stagesEsuggesting that HIP was inversely correlated to metastasis. The present study shows the presence of mutations in human metastatic colorectal cancer tissue and a cell line. Interestingly, a 12-base deletion encoding the heparin/heparan sulfate binding motif was common between the metastatic tissue and cell line. There was no mutation in the primary carcinoma and normal tissue. The findings suggest an important role for HIP in colorectal cancer metastasis.

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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Tan S and Hooi SC: The HIP gene encoding a heparin/heparan sulfate interacting protein is mutated in metastatic human colorectal cancer. Int J Mol Med 11: 473-477, 2003.
APA
Wang, Y., Tan, S., & Hooi, S.C. (2003). The HIP gene encoding a heparin/heparan sulfate interacting protein is mutated in metastatic human colorectal cancer. International Journal of Molecular Medicine, 11, 473-477. https://doi.org/10.3892/ijmm.11.4.473
MLA
Wang, Y., Tan, S., Hooi, S. C."The HIP gene encoding a heparin/heparan sulfate interacting protein is mutated in metastatic human colorectal cancer". International Journal of Molecular Medicine 11.4 (2003): 473-477.
Chicago
Wang, Y., Tan, S., Hooi, S. C."The HIP gene encoding a heparin/heparan sulfate interacting protein is mutated in metastatic human colorectal cancer". International Journal of Molecular Medicine 11, no. 4 (2003): 473-477. https://doi.org/10.3892/ijmm.11.4.473
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Tan S and Hooi SC: The HIP gene encoding a heparin/heparan sulfate interacting protein is mutated in metastatic human colorectal cancer. Int J Mol Med 11: 473-477, 2003.
APA
Wang, Y., Tan, S., & Hooi, S.C. (2003). The HIP gene encoding a heparin/heparan sulfate interacting protein is mutated in metastatic human colorectal cancer. International Journal of Molecular Medicine, 11, 473-477. https://doi.org/10.3892/ijmm.11.4.473
MLA
Wang, Y., Tan, S., Hooi, S. C."The HIP gene encoding a heparin/heparan sulfate interacting protein is mutated in metastatic human colorectal cancer". International Journal of Molecular Medicine 11.4 (2003): 473-477.
Chicago
Wang, Y., Tan, S., Hooi, S. C."The HIP gene encoding a heparin/heparan sulfate interacting protein is mutated in metastatic human colorectal cancer". International Journal of Molecular Medicine 11, no. 4 (2003): 473-477. https://doi.org/10.3892/ijmm.11.4.473
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