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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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May 2003 Volume 11 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2003 Volume 11 Issue 5

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Article

Dextromethorphan alters gene expression in rat brain hippocampus and cortex

  • Authors:
    • Ki-Hwan Lee
    • Joon-Ik Ahn
    • Dong-Hyun Yu
    • Hyun Chul Koh
    • Seok Hyeon Kim
    • Byung Hwan Yang
    • Young Seek Lee
    • Yong-Sung Lee

  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, College of Medicine and The Mental Health Research Institute, Hanyang University, Seoul, Korea
  • Pages: 559-568
    |
    Published online on: May 1, 2003
       https://doi.org/10.3892/ijmm.11.5.559
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Abstract

Dextromethorphan is a widely used anti-tussive drug with non-competitive antagonistic effects on excitatory amino acid receptors of the N-methyl-D-aspartate (NMDA) type. This study examined the effect of daily dextromethorphan administration on gene expression in rat brain hippocampus and cortex regions using Rat 5K cDNA microarrays. Triplicate microarray assays were performed at each time point (1, 3 and 10 days), and results were confirmed using semi-quantitative RT-PCR on a subset of differentially expressed cDNA. The microarray analysis proved able to detect changes in gene expression following dextromethorphan injection. Moreover, these changes were mostly mediated by an NMDA receptor. The hippocampus region showed more alterations in gene expression than cerebral cortex following dextromethorphan treatment. The expression of many glutamate-induced apoptosis-related genes, and NO-dependent apoptosis-associated genes, was down-regulated. Expression of anti-apoptotic genes, such as nucleophosmin/B23, Rab2, MAP kinase kinase and CREB binding protein, was up-regulated by dextromethorphan. Angiogenesis is likely to be inhibited in our system due to observed down-regulation of VEGF-associated genes. Expression of some SNARE genes was up-regulated in rat brain hippocampus and cortex regions after dextromethorphan injection.

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Copy and paste a formatted citation
Spandidos Publications style
Lee K, Ahn J, Yu D, Koh HC, Kim SH, Yang BH, Lee YS and Lee Y: Dextromethorphan alters gene expression in rat brain hippocampus and cortex. Int J Mol Med 11: 559-568, 2003.
APA
Lee, K., Ahn, J., Yu, D., Koh, H.C., Kim, S.H., Yang, B.H. ... Lee, Y. (2003). Dextromethorphan alters gene expression in rat brain hippocampus and cortex. International Journal of Molecular Medicine, 11, 559-568. https://doi.org/10.3892/ijmm.11.5.559
MLA
Lee, K., Ahn, J., Yu, D., Koh, H. C., Kim, S. H., Yang, B. H., Lee, Y. S., Lee, Y."Dextromethorphan alters gene expression in rat brain hippocampus and cortex". International Journal of Molecular Medicine 11.5 (2003): 559-568.
Chicago
Lee, K., Ahn, J., Yu, D., Koh, H. C., Kim, S. H., Yang, B. H., Lee, Y. S., Lee, Y."Dextromethorphan alters gene expression in rat brain hippocampus and cortex". International Journal of Molecular Medicine 11, no. 5 (2003): 559-568. https://doi.org/10.3892/ijmm.11.5.559
Copy and paste a formatted citation
x
Spandidos Publications style
Lee K, Ahn J, Yu D, Koh HC, Kim SH, Yang BH, Lee YS and Lee Y: Dextromethorphan alters gene expression in rat brain hippocampus and cortex. Int J Mol Med 11: 559-568, 2003.
APA
Lee, K., Ahn, J., Yu, D., Koh, H.C., Kim, S.H., Yang, B.H. ... Lee, Y. (2003). Dextromethorphan alters gene expression in rat brain hippocampus and cortex. International Journal of Molecular Medicine, 11, 559-568. https://doi.org/10.3892/ijmm.11.5.559
MLA
Lee, K., Ahn, J., Yu, D., Koh, H. C., Kim, S. H., Yang, B. H., Lee, Y. S., Lee, Y."Dextromethorphan alters gene expression in rat brain hippocampus and cortex". International Journal of Molecular Medicine 11.5 (2003): 559-568.
Chicago
Lee, K., Ahn, J., Yu, D., Koh, H. C., Kim, S. H., Yang, B. H., Lee, Y. S., Lee, Y."Dextromethorphan alters gene expression in rat brain hippocampus and cortex". International Journal of Molecular Medicine 11, no. 5 (2003): 559-568. https://doi.org/10.3892/ijmm.11.5.559
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