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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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May 2003 Volume 11 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Sepsis: A follow-up of cytokine production in different phases of septic patients

  • Authors:
    • Gloria Adriana Martins
    • Maria Da Gloria Da Costa Carvalho
    • Cerli Rocha Gattass

  • View Affiliations / Copyright

    Affiliations: Laboratório de Controle da Expressão Gênica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
  • Pages: 585-591
    |
    Published online on: May 1, 2003
       https://doi.org/10.3892/ijmm.11.5.585
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Abstract

Sepsis and its sequelae are still a major cause of morbidity and mortality on today's intensive care units. The evidence that primary responses in sepsis are mediated by cytokines has led to various approaches to evaluate the potential of these mediators as markers of disease progression, prognosis or treatment. This study evaluated variations of plasma levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1 (IL-1) and nitric oxide (NO) in different phases of sepsis and compared the relation of these data with disease evaluation and outcome. No difference in interleukin production in different phases of septic patients or between septic and polytrauma group was found. The only parameter that showed correlation with disease severity was the increase in interleukin-6 in final phase of sepsis, which corresponds to septic shock. No significant difference in plasma cytokine levels was found between survival or non-survival septic or polytraumatic patients and the use of carbapenem and cephalosporin. Taken together, the data indicate that, with the exception of interleukin-6, cytokine determination does not serve as marker of infectious disease nor can it be used to predict the prognosis of sepsis.

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Copy and paste a formatted citation
Spandidos Publications style
Martins GA, Da Gloria Da Costa Carvalho M and Rocha Gattass C: Sepsis: A follow-up of cytokine production in different phases of septic patients. Int J Mol Med 11: 585-591, 2003.
APA
Martins, G.A., Da Gloria Da Costa Carvalho, M., & Rocha Gattass, C. (2003). Sepsis: A follow-up of cytokine production in different phases of septic patients. International Journal of Molecular Medicine, 11, 585-591. https://doi.org/10.3892/ijmm.11.5.585
MLA
Martins, G. A., Da Gloria Da Costa Carvalho, M., Rocha Gattass, C."Sepsis: A follow-up of cytokine production in different phases of septic patients". International Journal of Molecular Medicine 11.5 (2003): 585-591.
Chicago
Martins, G. A., Da Gloria Da Costa Carvalho, M., Rocha Gattass, C."Sepsis: A follow-up of cytokine production in different phases of septic patients". International Journal of Molecular Medicine 11, no. 5 (2003): 585-591. https://doi.org/10.3892/ijmm.11.5.585
Copy and paste a formatted citation
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Spandidos Publications style
Martins GA, Da Gloria Da Costa Carvalho M and Rocha Gattass C: Sepsis: A follow-up of cytokine production in different phases of septic patients. Int J Mol Med 11: 585-591, 2003.
APA
Martins, G.A., Da Gloria Da Costa Carvalho, M., & Rocha Gattass, C. (2003). Sepsis: A follow-up of cytokine production in different phases of septic patients. International Journal of Molecular Medicine, 11, 585-591. https://doi.org/10.3892/ijmm.11.5.585
MLA
Martins, G. A., Da Gloria Da Costa Carvalho, M., Rocha Gattass, C."Sepsis: A follow-up of cytokine production in different phases of septic patients". International Journal of Molecular Medicine 11.5 (2003): 585-591.
Chicago
Martins, G. A., Da Gloria Da Costa Carvalho, M., Rocha Gattass, C."Sepsis: A follow-up of cytokine production in different phases of septic patients". International Journal of Molecular Medicine 11, no. 5 (2003): 585-591. https://doi.org/10.3892/ijmm.11.5.585
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