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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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May 2003 Volume 11 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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May 2003 Volume 11 Issue 5

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Article

Epigenetic changes in pilocytic astrocytomas and medulloblastomas

  • Authors:
    • Pilar Gonzalez-Gomez
    • M. Josefa Bello
    • Jesus Lomas
    • Dolores Arjona
    • M. Eva Alonso
    • Cinthia Amiñoso
    • Jose M. De Campos
    • Jesus Vaquero
    • Jose L. Sarasa
    • Cacilda Casartelli
    • Juan A. Rey

  • View Affiliations / Copyright

    Affiliations: Department of C. Experimental, Laboratorio de Oncogenetica Molecular, Hospital Universitario La Paz, 28046 Madrid, Spain
  • Pages: 655-660
    |
    Published online on: May 1, 2003
       https://doi.org/10.3892/ijmm.11.5.655
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Abstract

Aberrant methylation of CpG islands located in promoter regions represents one of the major mechanisms for silencing of cancer-related genes in tumour cells. We determined the frequency of aberrant CpG island methylation of several tumour-associated genes: MGMT, GSTP1, DAPK, p14ARF, THBS1, TIMP-3, p73, p16INK4A, RB1 and TP53 in 24 neurogenic tumours consisting of pilocytic astrocytomas (n=13) and medulloblastomas (n=11). The methylation index (number methylated genes/total genes analysed) displayed slight differences (0.18 and 0.25, respectively), and the profile of methylated genes in the two neoplasms was distinct, as predicted. The main differences involved the methylation rate of GSTP1 (0% in pilocytic astrocytomas vs. 18% medulloblastomas) and p14ARF (0% in pilocytic astrocytomas vs. 45% in medulloblastomas) genes. Pilocytic astrocytomas also demonstrated some differences when compared to methylation data from other astrocytic tumours, primarily regarding the MGMT methylation rate. Despite the fact that these differences do not show specific tumour-associated gene methylation patterns, our findings should help us understand the pathogenic mechanisms of both neurogenic neoplasm types.

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Copy and paste a formatted citation
Spandidos Publications style
Gonzalez-Gomez P, Bello MJ, Lomas J, Arjona D, Alonso ME, Amiñoso C, De Campos JM, Vaquero J, Sarasa JL, Casartelli C, Casartelli C, et al: Epigenetic changes in pilocytic astrocytomas and medulloblastomas. Int J Mol Med 11: 655-660, 2003.
APA
Gonzalez-Gomez, P., Bello, M.J., Lomas, J., Arjona, D., Alonso, M.E., Amiñoso, C. ... Rey, J.A. (2003). Epigenetic changes in pilocytic astrocytomas and medulloblastomas. International Journal of Molecular Medicine, 11, 655-660. https://doi.org/10.3892/ijmm.11.5.655
MLA
Gonzalez-Gomez, P., Bello, M. J., Lomas, J., Arjona, D., Alonso, M. E., Amiñoso, C., De Campos, J. M., Vaquero, J., Sarasa, J. L., Casartelli, C., Rey, J. A."Epigenetic changes in pilocytic astrocytomas and medulloblastomas". International Journal of Molecular Medicine 11.5 (2003): 655-660.
Chicago
Gonzalez-Gomez, P., Bello, M. J., Lomas, J., Arjona, D., Alonso, M. E., Amiñoso, C., De Campos, J. M., Vaquero, J., Sarasa, J. L., Casartelli, C., Rey, J. A."Epigenetic changes in pilocytic astrocytomas and medulloblastomas". International Journal of Molecular Medicine 11, no. 5 (2003): 655-660. https://doi.org/10.3892/ijmm.11.5.655
Copy and paste a formatted citation
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Spandidos Publications style
Gonzalez-Gomez P, Bello MJ, Lomas J, Arjona D, Alonso ME, Amiñoso C, De Campos JM, Vaquero J, Sarasa JL, Casartelli C, Casartelli C, et al: Epigenetic changes in pilocytic astrocytomas and medulloblastomas. Int J Mol Med 11: 655-660, 2003.
APA
Gonzalez-Gomez, P., Bello, M.J., Lomas, J., Arjona, D., Alonso, M.E., Amiñoso, C. ... Rey, J.A. (2003). Epigenetic changes in pilocytic astrocytomas and medulloblastomas. International Journal of Molecular Medicine, 11, 655-660. https://doi.org/10.3892/ijmm.11.5.655
MLA
Gonzalez-Gomez, P., Bello, M. J., Lomas, J., Arjona, D., Alonso, M. E., Amiñoso, C., De Campos, J. M., Vaquero, J., Sarasa, J. L., Casartelli, C., Rey, J. A."Epigenetic changes in pilocytic astrocytomas and medulloblastomas". International Journal of Molecular Medicine 11.5 (2003): 655-660.
Chicago
Gonzalez-Gomez, P., Bello, M. J., Lomas, J., Arjona, D., Alonso, M. E., Amiñoso, C., De Campos, J. M., Vaquero, J., Sarasa, J. L., Casartelli, C., Rey, J. A."Epigenetic changes in pilocytic astrocytomas and medulloblastomas". International Journal of Molecular Medicine 11, no. 5 (2003): 655-660. https://doi.org/10.3892/ijmm.11.5.655
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