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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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August 2003 Volume 12 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Ghrelin, an endogenous ligand for the growth hormone-secretagogue receptor, is expressed in the human adrenal cortex

  • Authors:
    • Cinzia Tortorella
    • Carlo Macchi
    • Raffaella Spinazzi
    • Ludwik K. Malendowicz
    • Marcin trejter
    • Gastone G. Nussdorfer

  • View Affiliations / Copyright

    Affiliations: Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, I-35121 Padua, Italy
  • Pages: 213-217
    |
    Published online on: August 1, 2003
       https://doi.org/10.3892/ijmm.12.2.213
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Abstract

Ghrelin is an endogenous ligand of the growth hormone secretagogue receptor (GHS-R), which was originally isolated from rat stomach. Ghrelin and GHS-R are also expressed in several peripheral tissues, including adrenal glands, and this prompted us to study ghrelin expression and ghrelin-binding site localization in the human adrenal cortex, and the possible effect of this peptide on corticosteroid-hormone secretion. Reverse transcription-polymerase chain reaction (RT-PCR) and radioimmune assay (RIA) showed sizeable expression of ghrelin mRNA and protein in six human adrenal cortexes. Autoradiography evidenced abundant [125I]ghrelin binding sites in the adrenal zona glomerulosa and outer zona fasciculata. However, ghrelin (10−6 M) did not significantly affect either basal or agonist (ACTH and angiotensin-II)-stimulated early and late steps of steroid-hormone synthesis from adrenocortical slices (as measured by quantitative high pressure liquid chromatography). Since zona glomerulosa is the cambium layer involved in the growth maintenance of adrenal cortex, the present coupled RT-PCR, RIA and autoradiographic findings could suggest the involvement of ghrelin in the autocrine-paracrine regulation of human adrenal growth.

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Copy and paste a formatted citation
Spandidos Publications style
Tortorella C, Macchi C, Spinazzi R, Malendowicz LK, trejter M and Nussdorfer GG: Ghrelin, an endogenous ligand for the growth hormone-secretagogue receptor, is expressed in the human adrenal cortex. Int J Mol Med 12: 213-217, 2003.
APA
Tortorella, C., Macchi, C., Spinazzi, R., Malendowicz, L.K., trejter, M., & Nussdorfer, G.G. (2003). Ghrelin, an endogenous ligand for the growth hormone-secretagogue receptor, is expressed in the human adrenal cortex. International Journal of Molecular Medicine, 12, 213-217. https://doi.org/10.3892/ijmm.12.2.213
MLA
Tortorella, C., Macchi, C., Spinazzi, R., Malendowicz, L. K., trejter, M., Nussdorfer, G. G."Ghrelin, an endogenous ligand for the growth hormone-secretagogue receptor, is expressed in the human adrenal cortex". International Journal of Molecular Medicine 12.2 (2003): 213-217.
Chicago
Tortorella, C., Macchi, C., Spinazzi, R., Malendowicz, L. K., trejter, M., Nussdorfer, G. G."Ghrelin, an endogenous ligand for the growth hormone-secretagogue receptor, is expressed in the human adrenal cortex". International Journal of Molecular Medicine 12, no. 2 (2003): 213-217. https://doi.org/10.3892/ijmm.12.2.213
Copy and paste a formatted citation
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Spandidos Publications style
Tortorella C, Macchi C, Spinazzi R, Malendowicz LK, trejter M and Nussdorfer GG: Ghrelin, an endogenous ligand for the growth hormone-secretagogue receptor, is expressed in the human adrenal cortex. Int J Mol Med 12: 213-217, 2003.
APA
Tortorella, C., Macchi, C., Spinazzi, R., Malendowicz, L.K., trejter, M., & Nussdorfer, G.G. (2003). Ghrelin, an endogenous ligand for the growth hormone-secretagogue receptor, is expressed in the human adrenal cortex. International Journal of Molecular Medicine, 12, 213-217. https://doi.org/10.3892/ijmm.12.2.213
MLA
Tortorella, C., Macchi, C., Spinazzi, R., Malendowicz, L. K., trejter, M., Nussdorfer, G. G."Ghrelin, an endogenous ligand for the growth hormone-secretagogue receptor, is expressed in the human adrenal cortex". International Journal of Molecular Medicine 12.2 (2003): 213-217.
Chicago
Tortorella, C., Macchi, C., Spinazzi, R., Malendowicz, L. K., trejter, M., Nussdorfer, G. G."Ghrelin, an endogenous ligand for the growth hormone-secretagogue receptor, is expressed in the human adrenal cortex". International Journal of Molecular Medicine 12, no. 2 (2003): 213-217. https://doi.org/10.3892/ijmm.12.2.213
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