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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2003 Volume 12 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

A further case of acute myelomonocytic leukemia with inv(8) chromosomal rearrangement and MOZ-NCOA2 gene fusion

  • Authors:
    • Anne Murati
    • José Adélaïde
    • Cornel Popovici
    • Marie-Joëlle Mozziconacci
    • Christine Arnoulet
    • Marina Lafage-Pochitaloff
    • Danielle Sainty
    • Daniel Birnbaum
    • Max Chaffanet

  • View Affiliations / Copyright

    Affiliations: Département d'Oncologie Moléculaire, Laboratoire de Cytogénétique Moléculaire, Institut Paoli-Calmettes and U119 Inserm, Marseille, France
  • Pages: 423-428
    |
    Published online on: October 1, 2003
       https://doi.org/10.3892/ijmm.12.4.423
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Abstract

We report here the sixth case of acute monoblastic leukemia associated with the inv(8)(p11q13) pericentric inversion. As seen in the previous cases, the inv(8)(p11q13) molecular characterization showed that the alteration results in a MOZ-NCOA2 gene fusion. The presence of erythrophagocytosis is a distinctive morphologic feature that is observed in all patients with MOZ alteration. However, the relative young age of the 6 patients (median: 23.5 years) and same sex (female) are the common characteristics that are only observed in the inv(8)-positive leukemia subgroup. In addition, we tested whether the presence of FLT3 internal duplications (ITD) are frequently found in malignant hemopathies with 8p11-12 rearrangements. We did not find any FLT3 ITD in any of the studied cases.

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Copy and paste a formatted citation
Spandidos Publications style
Murati A, Adélaïde J, Popovici C, Mozziconacci M, Arnoulet C, Lafage-Pochitaloff M, Sainty D, Birnbaum D and Chaffanet M: A further case of acute myelomonocytic leukemia with inv(8) chromosomal rearrangement and MOZ-NCOA2 gene fusion. Int J Mol Med 12: 423-428, 2003.
APA
Murati, A., Adélaïde, J., Popovici, C., Mozziconacci, M., Arnoulet, C., Lafage-Pochitaloff, M. ... Chaffanet, M. (2003). A further case of acute myelomonocytic leukemia with inv(8) chromosomal rearrangement and MOZ-NCOA2 gene fusion. International Journal of Molecular Medicine, 12, 423-428. https://doi.org/10.3892/ijmm.12.4.423
MLA
Murati, A., Adélaïde, J., Popovici, C., Mozziconacci, M., Arnoulet, C., Lafage-Pochitaloff, M., Sainty, D., Birnbaum, D., Chaffanet, M."A further case of acute myelomonocytic leukemia with inv(8) chromosomal rearrangement and MOZ-NCOA2 gene fusion". International Journal of Molecular Medicine 12.4 (2003): 423-428.
Chicago
Murati, A., Adélaïde, J., Popovici, C., Mozziconacci, M., Arnoulet, C., Lafage-Pochitaloff, M., Sainty, D., Birnbaum, D., Chaffanet, M."A further case of acute myelomonocytic leukemia with inv(8) chromosomal rearrangement and MOZ-NCOA2 gene fusion". International Journal of Molecular Medicine 12, no. 4 (2003): 423-428. https://doi.org/10.3892/ijmm.12.4.423
Copy and paste a formatted citation
x
Spandidos Publications style
Murati A, Adélaïde J, Popovici C, Mozziconacci M, Arnoulet C, Lafage-Pochitaloff M, Sainty D, Birnbaum D and Chaffanet M: A further case of acute myelomonocytic leukemia with inv(8) chromosomal rearrangement and MOZ-NCOA2 gene fusion. Int J Mol Med 12: 423-428, 2003.
APA
Murati, A., Adélaïde, J., Popovici, C., Mozziconacci, M., Arnoulet, C., Lafage-Pochitaloff, M. ... Chaffanet, M. (2003). A further case of acute myelomonocytic leukemia with inv(8) chromosomal rearrangement and MOZ-NCOA2 gene fusion. International Journal of Molecular Medicine, 12, 423-428. https://doi.org/10.3892/ijmm.12.4.423
MLA
Murati, A., Adélaïde, J., Popovici, C., Mozziconacci, M., Arnoulet, C., Lafage-Pochitaloff, M., Sainty, D., Birnbaum, D., Chaffanet, M."A further case of acute myelomonocytic leukemia with inv(8) chromosomal rearrangement and MOZ-NCOA2 gene fusion". International Journal of Molecular Medicine 12.4 (2003): 423-428.
Chicago
Murati, A., Adélaïde, J., Popovici, C., Mozziconacci, M., Arnoulet, C., Lafage-Pochitaloff, M., Sainty, D., Birnbaum, D., Chaffanet, M."A further case of acute myelomonocytic leukemia with inv(8) chromosomal rearrangement and MOZ-NCOA2 gene fusion". International Journal of Molecular Medicine 12, no. 4 (2003): 423-428. https://doi.org/10.3892/ijmm.12.4.423
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