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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2003 Volume 12 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Factor V Leiden mutation (R506Q) and the risk of advanced retinopathy of prematurity

  • Authors:
    • Sarah Kleinberg
    • Scott Garrant
    • Terri Tillen
    • M. T. Trese
    • B. S. Shastry

  • View Affiliations / Copyright

    Affiliations: Department of Biological Sciences, Oakland University, Rochester, MI, USA
  • Pages: 469-472
    |
    Published online on: October 1, 2003
       https://doi.org/10.3892/ijmm.12.4.469
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Abstract

The coagulation factor V Leiden mutation was reported to be a significant (10.7%) risk factor for pre-term deliveries. It is also well known that a portion (10%) of very low birth weight premature babies develop advanced retinopathy of prematurity (ROP) which is a leading cause of blindness in children. However, the relationship between the Leiden mutation and development of advanced ROP is not known. In order to understand this relationship as well as genetic contribution to ROP, in this study, we have analyzed 100 pre-term infants with advanced ROP (stage 4B/5), 20 term babies with a clinically similar disease called familial exudative vitreoretinopathy (FEVR) and 16 normal babies from four different ethnic backgrounds. Our extensive analysis has identified a heterozygous Leiden mutation in four patients (4%) with advanced ROP and in one patient (5%) with sporadic FEVR. DNA sequence analysis has further confirmed this base change as well as heterozygosity. However, the frequency observed in the patients analyzed in our study is lower than reported frequency in the general population (5.4%). Therefore, statistically factor V mutation on its own is not a major risk factor for the above two disorders. However, it may be associated with other additive factors as might be expected for a complex genetic trait.

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Copy and paste a formatted citation
Spandidos Publications style
Kleinberg S, Garrant S, Tillen T, Trese MT and Shastry BS: Factor V Leiden mutation (R506Q) and the risk of advanced retinopathy of prematurity. Int J Mol Med 12: 469-472, 2003.
APA
Kleinberg, S., Garrant, S., Tillen, T., Trese, M.T., & Shastry, B.S. (2003). Factor V Leiden mutation (R506Q) and the risk of advanced retinopathy of prematurity. International Journal of Molecular Medicine, 12, 469-472. https://doi.org/10.3892/ijmm.12.4.469
MLA
Kleinberg, S., Garrant, S., Tillen, T., Trese, M. T., Shastry, B. S."Factor V Leiden mutation (R506Q) and the risk of advanced retinopathy of prematurity". International Journal of Molecular Medicine 12.4 (2003): 469-472.
Chicago
Kleinberg, S., Garrant, S., Tillen, T., Trese, M. T., Shastry, B. S."Factor V Leiden mutation (R506Q) and the risk of advanced retinopathy of prematurity". International Journal of Molecular Medicine 12, no. 4 (2003): 469-472. https://doi.org/10.3892/ijmm.12.4.469
Copy and paste a formatted citation
x
Spandidos Publications style
Kleinberg S, Garrant S, Tillen T, Trese MT and Shastry BS: Factor V Leiden mutation (R506Q) and the risk of advanced retinopathy of prematurity. Int J Mol Med 12: 469-472, 2003.
APA
Kleinberg, S., Garrant, S., Tillen, T., Trese, M.T., & Shastry, B.S. (2003). Factor V Leiden mutation (R506Q) and the risk of advanced retinopathy of prematurity. International Journal of Molecular Medicine, 12, 469-472. https://doi.org/10.3892/ijmm.12.4.469
MLA
Kleinberg, S., Garrant, S., Tillen, T., Trese, M. T., Shastry, B. S."Factor V Leiden mutation (R506Q) and the risk of advanced retinopathy of prematurity". International Journal of Molecular Medicine 12.4 (2003): 469-472.
Chicago
Kleinberg, S., Garrant, S., Tillen, T., Trese, M. T., Shastry, B. S."Factor V Leiden mutation (R506Q) and the risk of advanced retinopathy of prematurity". International Journal of Molecular Medicine 12, no. 4 (2003): 469-472. https://doi.org/10.3892/ijmm.12.4.469
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