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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2003 Volume 12 Issue 4

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

Light scattering characterization of synthetic MUC-1 peptides and their behavior in dilute solution

  • Authors:
    • Apostolos K. Rizos
    • Demetrios A. Spandidos
    • Elias Krambovitis

  • View Affiliations / Copyright

    Affiliations: Department of Chemistry, University of Crete, Heraklion 71409, Greece. rizos@chemistry.uoc.gr
  • Pages: 559-563
    |
    Published online on: October 1, 2003
       https://doi.org/10.3892/ijmm.12.4.559
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Abstract

Human epithelial mucin, MUC-1 is frequently expressed in adenocarcinoma. The sequentially-repeating nature of the core protein 20 a.a. polypeptide chain on the surface of malignant cells makes it a potential target for immunotherapy. Addressing the physicochemical role of these peptide tandem repeats (VNTR) in the structure of MUC-1 we have been prompted to use dynamic light scattering as an experimental tool to investigate peptide polymer size and dynamics directly in solution. We synthesized oligomeric VNTR peptides (monomer, trimer and pentamer) and studied their free behavior in aqueous solution. Our results revealed the simultaneous presence of three different relaxation modes corresponding to three different sizes. The small size is related to the expected hydrodynamic radius of the individual peptides, whereas the large size is associated with the presence of higher order peptide aggregates. The appearance of a third mode in the monomeric and trimeric MUC-1 reveals an actual peptide interaction.

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Copy and paste a formatted citation
Spandidos Publications style
Rizos AK, Spandidos DA and Krambovitis E: Light scattering characterization of synthetic MUC-1 peptides and their behavior in dilute solution. Int J Mol Med 12: 559-563, 2003.
APA
Rizos, A.K., Spandidos, D.A., & Krambovitis, E. (2003). Light scattering characterization of synthetic MUC-1 peptides and their behavior in dilute solution. International Journal of Molecular Medicine, 12, 559-563. https://doi.org/10.3892/ijmm.12.4.559
MLA
Rizos, A. K., Spandidos, D. A., Krambovitis, E."Light scattering characterization of synthetic MUC-1 peptides and their behavior in dilute solution". International Journal of Molecular Medicine 12.4 (2003): 559-563.
Chicago
Rizos, A. K., Spandidos, D. A., Krambovitis, E."Light scattering characterization of synthetic MUC-1 peptides and their behavior in dilute solution". International Journal of Molecular Medicine 12, no. 4 (2003): 559-563. https://doi.org/10.3892/ijmm.12.4.559
Copy and paste a formatted citation
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Spandidos Publications style
Rizos AK, Spandidos DA and Krambovitis E: Light scattering characterization of synthetic MUC-1 peptides and their behavior in dilute solution. Int J Mol Med 12: 559-563, 2003.
APA
Rizos, A.K., Spandidos, D.A., & Krambovitis, E. (2003). Light scattering characterization of synthetic MUC-1 peptides and their behavior in dilute solution. International Journal of Molecular Medicine, 12, 559-563. https://doi.org/10.3892/ijmm.12.4.559
MLA
Rizos, A. K., Spandidos, D. A., Krambovitis, E."Light scattering characterization of synthetic MUC-1 peptides and their behavior in dilute solution". International Journal of Molecular Medicine 12.4 (2003): 559-563.
Chicago
Rizos, A. K., Spandidos, D. A., Krambovitis, E."Light scattering characterization of synthetic MUC-1 peptides and their behavior in dilute solution". International Journal of Molecular Medicine 12, no. 4 (2003): 559-563. https://doi.org/10.3892/ijmm.12.4.559
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