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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2003 Volume 12 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

IL-2, IL-10, IL-15 and TNF are key regulators of murine T-cell lymphoma growth

  • Authors:
    • Maria Jose Cravisaco
    • Claudia Mongini
    • Elida Alvarez
    • Paula Ruybal
    • Ana Escalada
    • Mariano Sanchez-Lockhart
    • Silvia Hajos
    • Claudia Waldner

  • View Affiliations / Copyright

    Affiliations: Centro de Estudios Farmacológicos y Botánicos (CEFYBO), CONICET, Buenos Aires, 1414, Argentina. majo@interserver.com.ar
  • Pages: 627-632
    |
    Published online on: October 1, 2003
       https://doi.org/10.3892/ijmm.12.4.627
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Abstract

We studied the role of IL-2, IL-15, IL-10, TNF and IL-2 receptor complexes (IL-2R) produced constitutively by a T-cell lymphoma line (LBC) on their own proliferation. The constitutive expression of surface α, β and γ chains IL-2R was detected in tumor cells by flow cytometry. Using reverse-transcription PCR, mRNA for IL-2, IL-15, IL-10 and TNF were found to be present in LBC. In addition, tumor cells were found to constitutively express intracellular IL-2, IL-15, IL-10 and TNF. Despite the production of these cytokines by tumor cells, specific neutralising antibodies did not inhibit LBC proliferation; surprisingly, anti-IL-15 increased LBC cell growth. We also demonstrated that recombinant IL-2 or IL-15 enhanced LBC cell proliferation. Our data suggest that endogenous IL-2 and IL-15 may trigger the proliferation of lymphoma LBC cells, and so their growth could be regulated, at least partly, by IL-2/IL-15/IL-2R system. In addition, IL-10 and TNF, immunosuppressor and pro-metastatic cytokines, respectively, may promote the in vivo growth of the tumor. The fact that leukaemia-lymphoma cells produce simultaneously both IL-2 and IL-15 should be taken into consideration in the design of immunotherapy protocols directed to IL-2R.

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Copy and paste a formatted citation
Spandidos Publications style
Cravisaco MJ, Mongini C, Alvarez E, Ruybal P, Escalada A, Sanchez-Lockhart M, Hajos S and Waldner C: IL-2, IL-10, IL-15 and TNF are key regulators of murine T-cell lymphoma growth. Int J Mol Med 12: 627-632, 2003.
APA
Cravisaco, M.J., Mongini, C., Alvarez, E., Ruybal, P., Escalada, A., Sanchez-Lockhart, M. ... Waldner, C. (2003). IL-2, IL-10, IL-15 and TNF are key regulators of murine T-cell lymphoma growth. International Journal of Molecular Medicine, 12, 627-632. https://doi.org/10.3892/ijmm.12.4.627
MLA
Cravisaco, M. J., Mongini, C., Alvarez, E., Ruybal, P., Escalada, A., Sanchez-Lockhart, M., Hajos, S., Waldner, C."IL-2, IL-10, IL-15 and TNF are key regulators of murine T-cell lymphoma growth". International Journal of Molecular Medicine 12.4 (2003): 627-632.
Chicago
Cravisaco, M. J., Mongini, C., Alvarez, E., Ruybal, P., Escalada, A., Sanchez-Lockhart, M., Hajos, S., Waldner, C."IL-2, IL-10, IL-15 and TNF are key regulators of murine T-cell lymphoma growth". International Journal of Molecular Medicine 12, no. 4 (2003): 627-632. https://doi.org/10.3892/ijmm.12.4.627
Copy and paste a formatted citation
x
Spandidos Publications style
Cravisaco MJ, Mongini C, Alvarez E, Ruybal P, Escalada A, Sanchez-Lockhart M, Hajos S and Waldner C: IL-2, IL-10, IL-15 and TNF are key regulators of murine T-cell lymphoma growth. Int J Mol Med 12: 627-632, 2003.
APA
Cravisaco, M.J., Mongini, C., Alvarez, E., Ruybal, P., Escalada, A., Sanchez-Lockhart, M. ... Waldner, C. (2003). IL-2, IL-10, IL-15 and TNF are key regulators of murine T-cell lymphoma growth. International Journal of Molecular Medicine, 12, 627-632. https://doi.org/10.3892/ijmm.12.4.627
MLA
Cravisaco, M. J., Mongini, C., Alvarez, E., Ruybal, P., Escalada, A., Sanchez-Lockhart, M., Hajos, S., Waldner, C."IL-2, IL-10, IL-15 and TNF are key regulators of murine T-cell lymphoma growth". International Journal of Molecular Medicine 12.4 (2003): 627-632.
Chicago
Cravisaco, M. J., Mongini, C., Alvarez, E., Ruybal, P., Escalada, A., Sanchez-Lockhart, M., Hajos, S., Waldner, C."IL-2, IL-10, IL-15 and TNF are key regulators of murine T-cell lymphoma growth". International Journal of Molecular Medicine 12, no. 4 (2003): 627-632. https://doi.org/10.3892/ijmm.12.4.627
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