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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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November 2003 Volume 12 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2003 Volume 12 Issue 5

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Article

11q23-24 loss is associated with chromosomal instability in endometrial cancer

  • Authors:
    • Keiko Kawasaki
    • Yutaka Suehiro
    • Kenji Umayahara
    • Hitoshi Morioka
    • Takehisa Ito
    • Toshiaki Saito
    • Naoki Tsukamoto
    • Norihiro Sugino
    • Hiroshi Kato
    • Kohsuke Sasaki
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Yamaguchi University School of Medicine, Ube, Yamaguchi 755-8505, Japan. obgyn@yamaguchi-u.ac.jp
  • Pages: 727-731
    |
    Published online on: November 1, 2003
       https://doi.org/10.3892/ijmm.12.5.727
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Abstract

A loss of the DNA copy number at chromosomal region 11q23-24 as detected by comparative genomic hybridization (CGH) is a marker of poor prognosis in patients with endometrial cancer. Malignant tumors display genetic instability, which is classified into two types: microsatellite instability (MIN) and chromosomal instability (CIN). In the present study, we examined whether there is a relation between loss of 11q23-24 and genetic instability in endometrial adenocarcinoma. Loss of 11q23-24 was detected in 4 of 70 endometrial cancers by fluorescence in situ hybridization (FISH), and DNA aneuploidy was detected by laser scanning cytometry (LSC) in 14 tumors. All tumors with 11q23-24 loss were aneuploid, and three of them were considered to have CIN. These findings suggest that 11q23-24 contains gene(s) necessary for normal chromosome replication and cell division.

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Copy and paste a formatted citation
Spandidos Publications style
Kawasaki K, Suehiro Y, Umayahara K, Morioka H, Ito T, Saito T, Tsukamoto N, Sugino N, Kato H, Sasaki K, Sasaki K, et al: 11q23-24 loss is associated with chromosomal instability in endometrial cancer. Int J Mol Med 12: 727-731, 2003.
APA
Kawasaki, K., Suehiro, Y., Umayahara, K., Morioka, H., Ito, T., Saito, T. ... Sasaki, K. (2003). 11q23-24 loss is associated with chromosomal instability in endometrial cancer. International Journal of Molecular Medicine, 12, 727-731. https://doi.org/10.3892/ijmm.12.5.727
MLA
Kawasaki, K., Suehiro, Y., Umayahara, K., Morioka, H., Ito, T., Saito, T., Tsukamoto, N., Sugino, N., Kato, H., Sasaki, K."11q23-24 loss is associated with chromosomal instability in endometrial cancer". International Journal of Molecular Medicine 12.5 (2003): 727-731.
Chicago
Kawasaki, K., Suehiro, Y., Umayahara, K., Morioka, H., Ito, T., Saito, T., Tsukamoto, N., Sugino, N., Kato, H., Sasaki, K."11q23-24 loss is associated with chromosomal instability in endometrial cancer". International Journal of Molecular Medicine 12, no. 5 (2003): 727-731. https://doi.org/10.3892/ijmm.12.5.727
Copy and paste a formatted citation
x
Spandidos Publications style
Kawasaki K, Suehiro Y, Umayahara K, Morioka H, Ito T, Saito T, Tsukamoto N, Sugino N, Kato H, Sasaki K, Sasaki K, et al: 11q23-24 loss is associated with chromosomal instability in endometrial cancer. Int J Mol Med 12: 727-731, 2003.
APA
Kawasaki, K., Suehiro, Y., Umayahara, K., Morioka, H., Ito, T., Saito, T. ... Sasaki, K. (2003). 11q23-24 loss is associated with chromosomal instability in endometrial cancer. International Journal of Molecular Medicine, 12, 727-731. https://doi.org/10.3892/ijmm.12.5.727
MLA
Kawasaki, K., Suehiro, Y., Umayahara, K., Morioka, H., Ito, T., Saito, T., Tsukamoto, N., Sugino, N., Kato, H., Sasaki, K."11q23-24 loss is associated with chromosomal instability in endometrial cancer". International Journal of Molecular Medicine 12.5 (2003): 727-731.
Chicago
Kawasaki, K., Suehiro, Y., Umayahara, K., Morioka, H., Ito, T., Saito, T., Tsukamoto, N., Sugino, N., Kato, H., Sasaki, K."11q23-24 loss is associated with chromosomal instability in endometrial cancer". International Journal of Molecular Medicine 12, no. 5 (2003): 727-731. https://doi.org/10.3892/ijmm.12.5.727
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