11q23-24 loss is associated with chromosomal instability in endometrial cancer

  • Authors:
    • Keiko Kawasaki
    • Yutaka Suehiro
    • Kenji Umayahara
    • Hitoshi Morioka
    • Takehisa Ito
    • Toshiaki Saito
    • Naoki Tsukamoto
    • Norihiro Sugino
    • Hiroshi Kato
    • Kohsuke Sasaki
  • View Affiliations

  • Published online on: November 1, 2003     https://doi.org/10.3892/ijmm.12.5.727
  • Pages: 727-731
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Abstract

A loss of the DNA copy number at chromosomal region 11q23-24 as detected by comparative genomic hybridization (CGH) is a marker of poor prognosis in patients with endometrial cancer. Malignant tumors display genetic instability, which is classified into two types: microsatellite instability (MIN) and chromosomal instability (CIN). In the present study, we examined whether there is a relation between loss of 11q23-24 and genetic instability in endometrial adenocarcinoma. Loss of 11q23-24 was detected in 4 of 70 endometrial cancers by fluorescence in situ hybridization (FISH), and DNA aneuploidy was detected by laser scanning cytometry (LSC) in 14 tumors. All tumors with 11q23-24 loss were aneuploid, and three of them were considered to have CIN. These findings suggest that 11q23-24 contains gene(s) necessary for normal chromosome replication and cell division.

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November 2003
Volume 12 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Kawasaki K, Suehiro Y, Umayahara K, Morioka H, Ito T, Saito T, Tsukamoto N, Sugino N, Kato H, Sasaki K, Sasaki K, et al: 11q23-24 loss is associated with chromosomal instability in endometrial cancer. Int J Mol Med 12: 727-731, 2003
APA
Kawasaki, K., Suehiro, Y., Umayahara, K., Morioka, H., Ito, T., Saito, T. ... Sasaki, K. (2003). 11q23-24 loss is associated with chromosomal instability in endometrial cancer. International Journal of Molecular Medicine, 12, 727-731. https://doi.org/10.3892/ijmm.12.5.727
MLA
Kawasaki, K., Suehiro, Y., Umayahara, K., Morioka, H., Ito, T., Saito, T., Tsukamoto, N., Sugino, N., Kato, H., Sasaki, K."11q23-24 loss is associated with chromosomal instability in endometrial cancer". International Journal of Molecular Medicine 12.5 (2003): 727-731.
Chicago
Kawasaki, K., Suehiro, Y., Umayahara, K., Morioka, H., Ito, T., Saito, T., Tsukamoto, N., Sugino, N., Kato, H., Sasaki, K."11q23-24 loss is associated with chromosomal instability in endometrial cancer". International Journal of Molecular Medicine 12, no. 5 (2003): 727-731. https://doi.org/10.3892/ijmm.12.5.727