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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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November 2003 Volume 12 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2003 Volume 12 Issue 5

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Article

Preventive effect of zinc acexamate administration in streptozotocin-diabetic rats: Restoration of bone loss

  • Authors:
    • Masayoshi Yamaguchi
    • Satoshi Uchiyama
  • View Affiliations / Copyright

    Affiliations: Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka 422-8526, Japan. yamaguch@u-shizuoka-ken.ac.jp
  • Pages: 755-761
    |
    Published online on: November 1, 2003
       https://doi.org/10.3892/ijmm.12.5.755
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Abstract

The preventive effect of zinc compounds on bone loss in streptozotocin (STZ)-diabetic rats was investigated. Rats received a single subcutaneous administration of STZ (6.0 mg/100 g body weight), and 7, 14 or 21 days later the animals were sacrificed by bleeding. STZ administration caused a significant decrease in body weight and a significant increase in serum glucose and triglyceride levels, indicating diabetic condition. Femoral-diaphyseal and -metaphyseal alkaline phosphatase activity, calcium and deoxyribonucleic acid (DNA) contents were significantly decreased by STZ administration, showing that diabetic condition causes bone loss. Zinc sulfate (2.5 mg Zn/100 g) or zinc acexamate (2.5 mg Zn/100 g) was orally administered once daily for 14 days to rats received a single subcutaneous administration of STZ (6.0 mg/100 g). STZ administration-induced increase in serum glucose and triglyceride levels and decrease in body weight, femoral-diaphyseal and -metaphyseal alkaline phosphatase activity, DNA and calcium contents were significantly prevented by the administration of zinc acexamate. The preventive effect of zinc sulfate on bone components was not seen. The present results demonstrate that the administration of zinc acexamate has a preventive effect on bone loss in STZ-diabetic rats in vivo.

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Copy and paste a formatted citation
Spandidos Publications style
Yamaguchi M and Uchiyama S: Preventive effect of zinc acexamate administration in streptozotocin-diabetic rats: Restoration of bone loss. Int J Mol Med 12: 755-761, 2003.
APA
Yamaguchi, M., & Uchiyama, S. (2003). Preventive effect of zinc acexamate administration in streptozotocin-diabetic rats: Restoration of bone loss. International Journal of Molecular Medicine, 12, 755-761. https://doi.org/10.3892/ijmm.12.5.755
MLA
Yamaguchi, M., Uchiyama, S."Preventive effect of zinc acexamate administration in streptozotocin-diabetic rats: Restoration of bone loss". International Journal of Molecular Medicine 12.5 (2003): 755-761.
Chicago
Yamaguchi, M., Uchiyama, S."Preventive effect of zinc acexamate administration in streptozotocin-diabetic rats: Restoration of bone loss". International Journal of Molecular Medicine 12, no. 5 (2003): 755-761. https://doi.org/10.3892/ijmm.12.5.755
Copy and paste a formatted citation
x
Spandidos Publications style
Yamaguchi M and Uchiyama S: Preventive effect of zinc acexamate administration in streptozotocin-diabetic rats: Restoration of bone loss. Int J Mol Med 12: 755-761, 2003.
APA
Yamaguchi, M., & Uchiyama, S. (2003). Preventive effect of zinc acexamate administration in streptozotocin-diabetic rats: Restoration of bone loss. International Journal of Molecular Medicine, 12, 755-761. https://doi.org/10.3892/ijmm.12.5.755
MLA
Yamaguchi, M., Uchiyama, S."Preventive effect of zinc acexamate administration in streptozotocin-diabetic rats: Restoration of bone loss". International Journal of Molecular Medicine 12.5 (2003): 755-761.
Chicago
Yamaguchi, M., Uchiyama, S."Preventive effect of zinc acexamate administration in streptozotocin-diabetic rats: Restoration of bone loss". International Journal of Molecular Medicine 12, no. 5 (2003): 755-761. https://doi.org/10.3892/ijmm.12.5.755
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