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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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November 2003 Volume 12 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2003 Volume 12 Issue 5

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Article

Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-3 (E-NPP3/CD203c/PD-Iβ/B10/gp130RB13-6) in human colon carcinoma

  • Authors:
    • Yoshihiko Yano
    • Yoshitake Hayashi
    • Kimihiko Sano
    • Hiroshi Shinmaru
    • Yoshikazu Kuroda
    • Hiroshi Yokozaki
    • Seitetsu Yoon
    • Masato Kasuga

  • View Affiliations / Copyright

    Affiliations: Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Chuo-Ku, Kobe 650-0017, Japan. yanoyo@med.kobe-u.ac.jp
  • Pages: 763-766
    |
    Published online on: November 1, 2003
       https://doi.org/10.3892/ijmm.12.5.763
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Abstract

Ecto-nucleotide pyrophosphatase/phospho-diesterase-I enzyme (E-NPP), one of the type II transmembrane proteins, cleaves phosphodiester and phosphosulfate bonds of a variety of substrates including deoxynucleotides, NAD, and nucleotide sugars. Mammalian E-NPP consists of three closely related family proteins; E-NPP1 (PC-1), E-NPP2 (PDNP2/PD-Iα/autotaxin), and E-NPP3 (CD203c/PDNP3/PD-Iβ/B10/gp130RB13-6) that express in different cells or at different locations even in the same cell. E-NPP3 is associated with malignant subversion and invasive properties. In this study, the expression and localization of E-NPP3 were investigated in human colon carcinoma. Western blotting showed strong E-NPP3 expression in cancer tissues and in the serum of colon carcinoma patients. Immunohistochemically, E-NPP3 was expressed not only in the apical but also in the basolateral plasma membranes of cancer cells. No prominent pattern of intracellular localization, and no relation between clinical stage and E-NPP3 expression were observed. Our results suggested that E-NPP3 is associated with carcinogenesis of human colon cancer and that serum E-NPP3 might be a tumor marker of colon carcinoma.

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Copy and paste a formatted citation
Spandidos Publications style
Yano Y, Hayashi Y, Sano K, Shinmaru H, Kuroda Y, Yokozaki H, Yoon S and Kasuga M: Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-3 (E-NPP3/CD203c/PD-Iβ/B10/gp130RB13-6) in human colon carcinoma. Int J Mol Med 12: 763-766, 2003.
APA
Yano, Y., Hayashi, Y., Sano, K., Shinmaru, H., Kuroda, Y., Yokozaki, H. ... Kasuga, M. (2003). Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-3 (E-NPP3/CD203c/PD-Iβ/B10/gp130RB13-6) in human colon carcinoma. International Journal of Molecular Medicine, 12, 763-766. https://doi.org/10.3892/ijmm.12.5.763
MLA
Yano, Y., Hayashi, Y., Sano, K., Shinmaru, H., Kuroda, Y., Yokozaki, H., Yoon, S., Kasuga, M."Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-3 (E-NPP3/CD203c/PD-Iβ/B10/gp130RB13-6) in human colon carcinoma". International Journal of Molecular Medicine 12.5 (2003): 763-766.
Chicago
Yano, Y., Hayashi, Y., Sano, K., Shinmaru, H., Kuroda, Y., Yokozaki, H., Yoon, S., Kasuga, M."Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-3 (E-NPP3/CD203c/PD-Iβ/B10/gp130RB13-6) in human colon carcinoma". International Journal of Molecular Medicine 12, no. 5 (2003): 763-766. https://doi.org/10.3892/ijmm.12.5.763
Copy and paste a formatted citation
x
Spandidos Publications style
Yano Y, Hayashi Y, Sano K, Shinmaru H, Kuroda Y, Yokozaki H, Yoon S and Kasuga M: Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-3 (E-NPP3/CD203c/PD-Iβ/B10/gp130RB13-6) in human colon carcinoma. Int J Mol Med 12: 763-766, 2003.
APA
Yano, Y., Hayashi, Y., Sano, K., Shinmaru, H., Kuroda, Y., Yokozaki, H. ... Kasuga, M. (2003). Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-3 (E-NPP3/CD203c/PD-Iβ/B10/gp130RB13-6) in human colon carcinoma. International Journal of Molecular Medicine, 12, 763-766. https://doi.org/10.3892/ijmm.12.5.763
MLA
Yano, Y., Hayashi, Y., Sano, K., Shinmaru, H., Kuroda, Y., Yokozaki, H., Yoon, S., Kasuga, M."Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-3 (E-NPP3/CD203c/PD-Iβ/B10/gp130RB13-6) in human colon carcinoma". International Journal of Molecular Medicine 12.5 (2003): 763-766.
Chicago
Yano, Y., Hayashi, Y., Sano, K., Shinmaru, H., Kuroda, Y., Yokozaki, H., Yoon, S., Kasuga, M."Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-3 (E-NPP3/CD203c/PD-Iβ/B10/gp130RB13-6) in human colon carcinoma". International Journal of Molecular Medicine 12, no. 5 (2003): 763-766. https://doi.org/10.3892/ijmm.12.5.763
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