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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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November 2003 Volume 12 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2003 Volume 12 Issue 5

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Article

Identification and expression analysis of a novel splice variant of human Sprouty1 gene

  • Authors:
    • Liu Wang
    • Chaoneng Ji
    • Hai Wu
    • Jian Xu
    • Qihan Wu
    • Jianfeng Dai
    • Gang Yin
    • Xin Ye
    • Shaohua Gu
    • Yi Xie
    • Yumin Mao

  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, P.R. China
  • Pages: 783-787
    |
    Published online on: November 1, 2003
       https://doi.org/10.3892/ijmm.12.5.783
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Abstract

Sprouty (SPRY) was first identified in a genetic screen in Drosophila to be an antagonist of fibroblast growth factor (FGF) and epidermal growth factor (EGF) signaling, seemingly by inhibiting the Ras/MAP kinase pathway. During large scale DNA sequencing of the human fetal brain cDNA library, we cloned a novel splice variant of human Sprouty1 gene, and termed it human Sprouty1b (SPRY1b). It has the same deduced protein as Sprouty1a, which has been reported. And like other members of Sprouty family, SPRY1b deduced protein also has a C-terminal cysteine-rich region. According to the search against human genome database, SPRY1b was mapped to 4q25-28. Expression analysis of SPRY1a and SPRY1b shows that they are hardly expressed in adult human, but have different expression patterns in fetus, which confirmed that SPRY1 is an important gene during fetal development.

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Copy and paste a formatted citation
Spandidos Publications style
Wang L, Ji C, Wu H, Xu J, Wu Q, Dai J, Yin G, Ye X, Gu S, Xie Y, Xie Y, et al: Identification and expression analysis of a novel splice variant of human Sprouty1 gene. Int J Mol Med 12: 783-787, 2003.
APA
Wang, L., Ji, C., Wu, H., Xu, J., Wu, Q., Dai, J. ... Mao, Y. (2003). Identification and expression analysis of a novel splice variant of human Sprouty1 gene. International Journal of Molecular Medicine, 12, 783-787. https://doi.org/10.3892/ijmm.12.5.783
MLA
Wang, L., Ji, C., Wu, H., Xu, J., Wu, Q., Dai, J., Yin, G., Ye, X., Gu, S., Xie, Y., Mao, Y."Identification and expression analysis of a novel splice variant of human Sprouty1 gene". International Journal of Molecular Medicine 12.5 (2003): 783-787.
Chicago
Wang, L., Ji, C., Wu, H., Xu, J., Wu, Q., Dai, J., Yin, G., Ye, X., Gu, S., Xie, Y., Mao, Y."Identification and expression analysis of a novel splice variant of human Sprouty1 gene". International Journal of Molecular Medicine 12, no. 5 (2003): 783-787. https://doi.org/10.3892/ijmm.12.5.783
Copy and paste a formatted citation
x
Spandidos Publications style
Wang L, Ji C, Wu H, Xu J, Wu Q, Dai J, Yin G, Ye X, Gu S, Xie Y, Xie Y, et al: Identification and expression analysis of a novel splice variant of human Sprouty1 gene. Int J Mol Med 12: 783-787, 2003.
APA
Wang, L., Ji, C., Wu, H., Xu, J., Wu, Q., Dai, J. ... Mao, Y. (2003). Identification and expression analysis of a novel splice variant of human Sprouty1 gene. International Journal of Molecular Medicine, 12, 783-787. https://doi.org/10.3892/ijmm.12.5.783
MLA
Wang, L., Ji, C., Wu, H., Xu, J., Wu, Q., Dai, J., Yin, G., Ye, X., Gu, S., Xie, Y., Mao, Y."Identification and expression analysis of a novel splice variant of human Sprouty1 gene". International Journal of Molecular Medicine 12.5 (2003): 783-787.
Chicago
Wang, L., Ji, C., Wu, H., Xu, J., Wu, Q., Dai, J., Yin, G., Ye, X., Gu, S., Xie, Y., Mao, Y."Identification and expression analysis of a novel splice variant of human Sprouty1 gene". International Journal of Molecular Medicine 12, no. 5 (2003): 783-787. https://doi.org/10.3892/ijmm.12.5.783
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