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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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December 2003 Volume 12 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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December 2003 Volume 12 Issue 6

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Article

Thrombospondin-1 induces apoptosis in primary leukemia and cell lines mediated by CD36 and Caspase-3

  • Authors:
    • Karen Li
    • Mo Yang
    • Patrick Man Pan Yuen
    • Ki Wai Chik
    • Chi Kong Li
    • Matthew Ming Kong Shing
    • Hubert Kin Bong Lam
    • Tai Fai Fok

  • View Affiliations / Copyright

    Affiliations: Department of Paediatrics, Prince of Wales Hospital, Shatin, N.T., Hong Kong. lipang@cuhk.edu.hk
  • Pages: 995-1001
    |
    Published online on: December 1, 2003
       https://doi.org/10.3892/ijmm.12.6.995
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Abstract

Thrombospondin-1 (TSP-1) is a naturally occurring anti-angiogenic compound that induces apoptosis of endothelial and cancer cells via its receptor CD36. The objectives of our study were to investigate the in vitro effects of TSP-1 on the apoptosis of primary human leukemia cells as well as leukemia cell lines and the possible mechanism involving CD36. Our results demonstrated that TSP-1 induced apoptosis in CD36 positive cell lines CHRF-288-11, Meg-01 and HL-60, but not CD36 negative K562, at a dose-dependent manner as demonstrated by DNA ladder formation, Annexin V and propidium iodide (PI) stainings. The addition of anti-CD36 antibody FA6-152 or thrombopoietin (TPO) significantly nullified the effects of TSP-1. TSP-1-mediated apoptosis was consistently associated with the up-regulation of active Caspase-3. Responses of 2 CD36 positive primary AML samples to TSP-1 and FA6-152 were similar with those of leukemia cell lines. TSP-1 significantly induced apoptosis in B-ALL but the counter-effects of FA6-152 were less apparent. CD36 negative AML cells appeared less susceptible to TSP-1 and FA6-152. Our data provided strong evidence that TSP-1 exerted direct apoptotic effects on leukemia cells and could be developed as an adjunct to conventional therapy, particularly for leukemia cells that express CD36 or other TSP-1 receptors.

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Copy and paste a formatted citation
Spandidos Publications style
Li K, Yang M, Yuen PM, Chik KW, Li CK, Shing MM, Lam HK and Fok TF: Thrombospondin-1 induces apoptosis in primary leukemia and cell lines mediated by CD36 and Caspase-3. Int J Mol Med 12: 995-1001, 2003.
APA
Li, K., Yang, M., Yuen, P.M., Chik, K.W., Li, C.K., Shing, M.M. ... Fok, T.F. (2003). Thrombospondin-1 induces apoptosis in primary leukemia and cell lines mediated by CD36 and Caspase-3. International Journal of Molecular Medicine, 12, 995-1001. https://doi.org/10.3892/ijmm.12.6.995
MLA
Li, K., Yang, M., Yuen, P. M., Chik, K. W., Li, C. K., Shing, M. M., Lam, H. K., Fok, T. F."Thrombospondin-1 induces apoptosis in primary leukemia and cell lines mediated by CD36 and Caspase-3". International Journal of Molecular Medicine 12.6 (2003): 995-1001.
Chicago
Li, K., Yang, M., Yuen, P. M., Chik, K. W., Li, C. K., Shing, M. M., Lam, H. K., Fok, T. F."Thrombospondin-1 induces apoptosis in primary leukemia and cell lines mediated by CD36 and Caspase-3". International Journal of Molecular Medicine 12, no. 6 (2003): 995-1001. https://doi.org/10.3892/ijmm.12.6.995
Copy and paste a formatted citation
x
Spandidos Publications style
Li K, Yang M, Yuen PM, Chik KW, Li CK, Shing MM, Lam HK and Fok TF: Thrombospondin-1 induces apoptosis in primary leukemia and cell lines mediated by CD36 and Caspase-3. Int J Mol Med 12: 995-1001, 2003.
APA
Li, K., Yang, M., Yuen, P.M., Chik, K.W., Li, C.K., Shing, M.M. ... Fok, T.F. (2003). Thrombospondin-1 induces apoptosis in primary leukemia and cell lines mediated by CD36 and Caspase-3. International Journal of Molecular Medicine, 12, 995-1001. https://doi.org/10.3892/ijmm.12.6.995
MLA
Li, K., Yang, M., Yuen, P. M., Chik, K. W., Li, C. K., Shing, M. M., Lam, H. K., Fok, T. F."Thrombospondin-1 induces apoptosis in primary leukemia and cell lines mediated by CD36 and Caspase-3". International Journal of Molecular Medicine 12.6 (2003): 995-1001.
Chicago
Li, K., Yang, M., Yuen, P. M., Chik, K. W., Li, C. K., Shing, M. M., Lam, H. K., Fok, T. F."Thrombospondin-1 induces apoptosis in primary leukemia and cell lines mediated by CD36 and Caspase-3". International Journal of Molecular Medicine 12, no. 6 (2003): 995-1001. https://doi.org/10.3892/ijmm.12.6.995
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