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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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January 2004 Volume 13 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Intracellular domain generation of amyloid precursor protein by ε-cleavage depends on C-terminal fragment by α-secretase cleavage

  • Authors:
    • Hideaki Kume
    • Kei Maruyama
    • Fuyuki Kametani

  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Tohoku University Graduate School of Medicine, Miyagi 980-8575, Japan
  • Pages: 121-125
    |
    Published online on: January 1, 2004
       https://doi.org/10.3892/ijmm.13.1.121
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Abstract

A significant accumulation of Aβ is major pathological feature in the brain in patients with Alzheimer's disease (AD). Amyloid precursor protein (APP) is cleaved by α- and β-secretase, resulting in secretion of extracellular domain. Then the remaining membrane-anchored C-terminal fragments (CTFα or CTFβ) are cleaved by γ-secretase. Therefore, Aβ is derived from APP by sequential proteolytic processing involving 2 proteases, called β- and γ-secretase. γ-Secretase cleavage results in the generation of the APP intracellular domain (AICD), as well as Aβ. Recently, AICD is generated by ε-cleavage site near the cytoplasmic membrane boundary of APP, not by γ-cleavage site in the middle of transmembrane domain. We show that elevated β-secretase levels induced the increase in CTFβ and Aβ generation and reduction of CTFα and AICD generation in vitro. Furthermore, elevated α-secretase levels induced an increase of AICD. The results suggest that generation of AICD by ε-cleavage depends on CTFα and that γ- and ε-cleavage are differentially regulated.

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Copy and paste a formatted citation
Spandidos Publications style
Kume H, Maruyama K and Kametani F: Intracellular domain generation of amyloid precursor protein by ε-cleavage depends on C-terminal fragment by α-secretase cleavage. Int J Mol Med 13: 121-125, 2004.
APA
Kume, H., Maruyama, K., & Kametani, F. (2004). Intracellular domain generation of amyloid precursor protein by ε-cleavage depends on C-terminal fragment by α-secretase cleavage. International Journal of Molecular Medicine, 13, 121-125. https://doi.org/10.3892/ijmm.13.1.121
MLA
Kume, H., Maruyama, K., Kametani, F."Intracellular domain generation of amyloid precursor protein by ε-cleavage depends on C-terminal fragment by α-secretase cleavage". International Journal of Molecular Medicine 13.1 (2004): 121-125.
Chicago
Kume, H., Maruyama, K., Kametani, F."Intracellular domain generation of amyloid precursor protein by ε-cleavage depends on C-terminal fragment by α-secretase cleavage". International Journal of Molecular Medicine 13, no. 1 (2004): 121-125. https://doi.org/10.3892/ijmm.13.1.121
Copy and paste a formatted citation
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Spandidos Publications style
Kume H, Maruyama K and Kametani F: Intracellular domain generation of amyloid precursor protein by ε-cleavage depends on C-terminal fragment by α-secretase cleavage. Int J Mol Med 13: 121-125, 2004.
APA
Kume, H., Maruyama, K., & Kametani, F. (2004). Intracellular domain generation of amyloid precursor protein by ε-cleavage depends on C-terminal fragment by α-secretase cleavage. International Journal of Molecular Medicine, 13, 121-125. https://doi.org/10.3892/ijmm.13.1.121
MLA
Kume, H., Maruyama, K., Kametani, F."Intracellular domain generation of amyloid precursor protein by ε-cleavage depends on C-terminal fragment by α-secretase cleavage". International Journal of Molecular Medicine 13.1 (2004): 121-125.
Chicago
Kume, H., Maruyama, K., Kametani, F."Intracellular domain generation of amyloid precursor protein by ε-cleavage depends on C-terminal fragment by α-secretase cleavage". International Journal of Molecular Medicine 13, no. 1 (2004): 121-125. https://doi.org/10.3892/ijmm.13.1.121
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