Urinary extracellular matrix measurement as a reliable and cost effective diagnostic tool for bladder tumors

  • Authors:
    • Rikio Yoshimura
    • Seiji Wada
    • Masahide Matsuyama
    • Taro Hase
    • Takeshi Goto
    • Tomoaki Tanaka
    • Katsuyuki Kuratsukuri
    • Kenji Tsuchida
    • Tatsuya Nakatani
  • View Affiliations

  • Published online on: January 1, 2004     https://doi.org/10.3892/ijmm.13.1.127
  • Pages: 127-131
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Abstract

Although numerous markers for bladder tumor (BT) have been investigated, a more effective, less expensive test is needed. To address this issue, we examined the urinary extracellular matrix (U-ECM) measurement in urine from patients with BT, and investigated the U-ECM measurement and its correlation with tumor grade and invasion. We also investigated the U-ECM measurement to ascertain the condition of the bladder wall injured by transurethral resection of bladder tumor (TUR-bt). Fresh urine samples were obtained from 170 patients with BT, 38 patients with chronic cystitis (CC) and 50 with normal bladder (NB). U-ECM measurements were higher in BT groups than in CC and in NB groups. There was no significant difference in the U-ECM measurement between grades. However, in another comparison between stages, U-ECM measurements were higher in advanced cancer than in early stage cancer. After surgery, U-ECM concentration increased on day 1 and levels of U-ECM that were higher prior to TUR-bt continued to increase until day 6. U-ECM continued to decrease after day 6 and reached normal range on day 14. Our results demonstrated that measurement of U-ECM is a highly efficient, reliable and cost effective marker for screening and monitoring bladder tumors and is also a beneficial diagnostic tool. Evaluation of the results is relatively simple and accurate and the running cost of measuring U-ECM is significantly lower than other tests.

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January 2004
Volume 13 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Yoshimura R, Wada S, Matsuyama M, Hase T, Goto T, Tanaka T, Kuratsukuri K, Tsuchida K and Nakatani T: Urinary extracellular matrix measurement as a reliable and cost effective diagnostic tool for bladder tumors. Int J Mol Med 13: 127-131, 2004
APA
Yoshimura, R., Wada, S., Matsuyama, M., Hase, T., Goto, T., Tanaka, T. ... Nakatani, T. (2004). Urinary extracellular matrix measurement as a reliable and cost effective diagnostic tool for bladder tumors. International Journal of Molecular Medicine, 13, 127-131. https://doi.org/10.3892/ijmm.13.1.127
MLA
Yoshimura, R., Wada, S., Matsuyama, M., Hase, T., Goto, T., Tanaka, T., Kuratsukuri, K., Tsuchida, K., Nakatani, T."Urinary extracellular matrix measurement as a reliable and cost effective diagnostic tool for bladder tumors". International Journal of Molecular Medicine 13.1 (2004): 127-131.
Chicago
Yoshimura, R., Wada, S., Matsuyama, M., Hase, T., Goto, T., Tanaka, T., Kuratsukuri, K., Tsuchida, K., Nakatani, T."Urinary extracellular matrix measurement as a reliable and cost effective diagnostic tool for bladder tumors". International Journal of Molecular Medicine 13, no. 1 (2004): 127-131. https://doi.org/10.3892/ijmm.13.1.127