Molecular cloning and characterization of a novel human BTBD8 gene containing double BTB/POZ domains

  • Authors:
    • Jian Xu
    • Ti He
    • Liu Wang
    • Qihan Wu
    • Enpeng Zhao
    • Maoqing Wu
    • Tonghai Dou
    • Chaoneng Ji
    • Shaohua Gu
    • Kang Yin
    • Yi Xie
    • Yumin Mao
  • View Affiliations

  • Published online on: January 1, 2004     https://doi.org/10.3892/ijmm.13.1.193
  • Pages: 193-197
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Abstract

BTB/POZ domain is an evolutionarily conserved protein-protein interaction domain often found in developmentally regulated transcription factors. Previous studies have shown that many additional conserved motifs have been found in association with BTB/POZ domain, including kelch repeats, zinc finger domains, FYVE fingers and ankyrin repeats. Here we report a novel human gene containing double BTB/POZ domains, named BTBD8 in agreement with the HUGO Nomenclature Committee. The cDNA sequence contains an open reading frame of 918 bp encoding a putative protein of 305 amino acid residues with a predicted molecular mass of 34.6 kDa. Protein pattern analysis shows that it contains double BTB/POZ domains. Weak expression was detected in adult brain and prostate of the 16 adult tissues examined, while it had a more abundant expression pattern in human fetal brain. The expression pattern of BTBD8 shows it may have a function related to brain development.

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January 2004
Volume 13 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Xu J, He T, Wang L, Wu Q, Zhao E, Wu M, Dou T, Ji C, Gu S, Yin K, Yin K, et al: Molecular cloning and characterization of a novel human BTBD8 gene containing double BTB/POZ domains. Int J Mol Med 13: 193-197, 2004
APA
Xu, J., He, T., Wang, L., Wu, Q., Zhao, E., Wu, M. ... Mao, Y. (2004). Molecular cloning and characterization of a novel human BTBD8 gene containing double BTB/POZ domains. International Journal of Molecular Medicine, 13, 193-197. https://doi.org/10.3892/ijmm.13.1.193
MLA
Xu, J., He, T., Wang, L., Wu, Q., Zhao, E., Wu, M., Dou, T., Ji, C., Gu, S., Yin, K., Xie, Y., Mao, Y."Molecular cloning and characterization of a novel human BTBD8 gene containing double BTB/POZ domains". International Journal of Molecular Medicine 13.1 (2004): 193-197.
Chicago
Xu, J., He, T., Wang, L., Wu, Q., Zhao, E., Wu, M., Dou, T., Ji, C., Gu, S., Yin, K., Xie, Y., Mao, Y."Molecular cloning and characterization of a novel human BTBD8 gene containing double BTB/POZ domains". International Journal of Molecular Medicine 13, no. 1 (2004): 193-197. https://doi.org/10.3892/ijmm.13.1.193