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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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January 2004 Volume 13 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2004 Volume 13 Issue 1

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Article

Mutational analysis of the BAK gene in 192 advanced gastric and colorectal cancers

  • Authors:
    • Ichiro Sakamoto
    • Tatsuya Yamada
    • Susumu Ohwada
    • Toru Koyama
    • Tetsuhiro Nakano
    • Toshio Okabe
    • Kunihiro Hamada
    • Susumu Kawate
    • Izumi Takeyoshi
    • Yuichi Iino
    • Yasuo Morishita

  • View Affiliations / Copyright

    Affiliations: Second Department of Surgery, Gunma University Faculty of Medicine, Gunma 371-8511, Japan
  • Pages: 53-55
    |
    Published online on: January 1, 2004
       https://doi.org/10.3892/ijmm.13.1.53
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Abstract

The evasion of apoptosis has been linked to the development of cancer. A recent study of a small number of gastric and colorectal cancers found that the BAK gene, which encodes a pro-apoptotic protein, contained somatic mutations in approximately 17% of the samples analyzed. To investigate the precise frequency of BAK mutations, we examined the entire coding sequence of the BAK gene in gastric and colorectal cancers, using polymerase chain reaction-single-strand conformational polymorphism (PCR-SSCP) analysis and direct sequencing. We could not detect any somatic mutations of the BAK gene in 192 colorectal and gastric cancers. We found only four single-nucleotide substitutions in the coding sequences, which were also found in corresponding normal samples. We conclude that somatic alterations of the BAK gene are rare in colorectal and gastric cancers.

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Copy and paste a formatted citation
Spandidos Publications style
Sakamoto I, Yamada T, Ohwada S, Koyama T, Nakano T, Okabe T, Hamada K, Kawate S, Takeyoshi I, Iino Y, Iino Y, et al: Mutational analysis of the BAK gene in 192 advanced gastric and colorectal cancers. Int J Mol Med 13: 53-55, 2004.
APA
Sakamoto, I., Yamada, T., Ohwada, S., Koyama, T., Nakano, T., Okabe, T. ... Morishita, Y. (2004). Mutational analysis of the BAK gene in 192 advanced gastric and colorectal cancers. International Journal of Molecular Medicine, 13, 53-55. https://doi.org/10.3892/ijmm.13.1.53
MLA
Sakamoto, I., Yamada, T., Ohwada, S., Koyama, T., Nakano, T., Okabe, T., Hamada, K., Kawate, S., Takeyoshi, I., Iino, Y., Morishita, Y."Mutational analysis of the BAK gene in 192 advanced gastric and colorectal cancers". International Journal of Molecular Medicine 13.1 (2004): 53-55.
Chicago
Sakamoto, I., Yamada, T., Ohwada, S., Koyama, T., Nakano, T., Okabe, T., Hamada, K., Kawate, S., Takeyoshi, I., Iino, Y., Morishita, Y."Mutational analysis of the BAK gene in 192 advanced gastric and colorectal cancers". International Journal of Molecular Medicine 13, no. 1 (2004): 53-55. https://doi.org/10.3892/ijmm.13.1.53
Copy and paste a formatted citation
x
Spandidos Publications style
Sakamoto I, Yamada T, Ohwada S, Koyama T, Nakano T, Okabe T, Hamada K, Kawate S, Takeyoshi I, Iino Y, Iino Y, et al: Mutational analysis of the BAK gene in 192 advanced gastric and colorectal cancers. Int J Mol Med 13: 53-55, 2004.
APA
Sakamoto, I., Yamada, T., Ohwada, S., Koyama, T., Nakano, T., Okabe, T. ... Morishita, Y. (2004). Mutational analysis of the BAK gene in 192 advanced gastric and colorectal cancers. International Journal of Molecular Medicine, 13, 53-55. https://doi.org/10.3892/ijmm.13.1.53
MLA
Sakamoto, I., Yamada, T., Ohwada, S., Koyama, T., Nakano, T., Okabe, T., Hamada, K., Kawate, S., Takeyoshi, I., Iino, Y., Morishita, Y."Mutational analysis of the BAK gene in 192 advanced gastric and colorectal cancers". International Journal of Molecular Medicine 13.1 (2004): 53-55.
Chicago
Sakamoto, I., Yamada, T., Ohwada, S., Koyama, T., Nakano, T., Okabe, T., Hamada, K., Kawate, S., Takeyoshi, I., Iino, Y., Morishita, Y."Mutational analysis of the BAK gene in 192 advanced gastric and colorectal cancers". International Journal of Molecular Medicine 13, no. 1 (2004): 53-55. https://doi.org/10.3892/ijmm.13.1.53
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