Germinated barley foodstuff prolongs remission in patients with ulcerative colitis

  • Authors:
    • Hiroyuki Hanai
    • Osamu Kanauchi
    • Keiichi Mitsuyama
    • Akira Andoh
    • Ken Takeuchi
    • Iida Takayuki
    • Yoshio Araki
    • Yoshihide Fujiyama
    • Atsushi Toyonaga
    • Michio Sata
    • Atsushi Kojima
    • Masanobu Fukuda
    • Tadao Bamba
  • View Affiliations

  • Published online on: May 1, 2004     https://doi.org/10.3892/ijmm.13.5.643
  • Pages: 643-647
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Abstract

Germinated barley foodstuff (GBF) is a prebiotic which increases luminal butyrate production by modulating the microfloral distribution. GBF has been shown to reduce both clinical activity and mucosal damage in active ulcerative colitis (UC) with mild to moderate activity. However, the efficacy of GBF in patients with UC during the remission stage is unknown. The aim of this study was to investigate the efficacy of GBF as a maintenance therapy in patients with UC while in remission. Fifty-nine patients with UC in remission according to Rachmilewitz's clinical activity index (CAI) score of ≤4 were enrolled and divided into two groups, control (n=37) and GBF (n=22). Patients in the control group were given conventional treatment alone for 12 months, while patients in the GBF group received conventional therapy plus 20 g of GBF daily. The response to treatments was assessed by monitoring the CAI and endoscopic score according to Matts. Significantly better CAI values were seen in the GBF group at 3, 6, and 12 months compared with the values in the control group. The cumulative recurrence rate in the GBF group with steroid tapering treatment was significantly lower compared with the value in the control group. No side effects related to GBF were observed. GBF appeared to be effective and safe as a maintenance therapy to taper steroid dose and prolong remission in patients with UC.

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May 2004
Volume 13 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Hanai H, Kanauchi O, Mitsuyama K, Andoh A, Takeuchi K, Takayuki I, Araki Y, Fujiyama Y, Toyonaga A, Sata M, Sata M, et al: Germinated barley foodstuff prolongs remission in patients with ulcerative colitis. Int J Mol Med 13: 643-647, 2004
APA
Hanai, H., Kanauchi, O., Mitsuyama, K., Andoh, A., Takeuchi, K., Takayuki, I. ... Bamba, T. (2004). Germinated barley foodstuff prolongs remission in patients with ulcerative colitis. International Journal of Molecular Medicine, 13, 643-647. https://doi.org/10.3892/ijmm.13.5.643
MLA
Hanai, H., Kanauchi, O., Mitsuyama, K., Andoh, A., Takeuchi, K., Takayuki, I., Araki, Y., Fujiyama, Y., Toyonaga, A., Sata, M., Kojima, A., Fukuda, M., Bamba, T."Germinated barley foodstuff prolongs remission in patients with ulcerative colitis". International Journal of Molecular Medicine 13.5 (2004): 643-647.
Chicago
Hanai, H., Kanauchi, O., Mitsuyama, K., Andoh, A., Takeuchi, K., Takayuki, I., Araki, Y., Fujiyama, Y., Toyonaga, A., Sata, M., Kojima, A., Fukuda, M., Bamba, T."Germinated barley foodstuff prolongs remission in patients with ulcerative colitis". International Journal of Molecular Medicine 13, no. 5 (2004): 643-647. https://doi.org/10.3892/ijmm.13.5.643