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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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August 2004 Volume 14 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2004 Volume 14 Issue 2

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Article

Ubiquitous p63 expression in human esophageal squamous cell carcinoma

  • Authors:
    • Tadashi Hara
    • Hiroshi Kijima
    • Soichiro Yamamoto
    • Takahiro Kenmochi
    • Yosifumi Kise
    • Hikaru Tanaka
    • Osamu Chino
    • Hideo Shimada
    • Kensuke Takazawa
    • Makiko Tanaka
    • Sadaki Inokuchi
    • Hiroyasu Makuuchi

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan
  • Pages: 169-173
    |
    Published online on: August 1, 2004
       https://doi.org/10.3892/ijmm.14.2.169
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Abstract

p63, a recently identified member of the p53 gene family, plays an important role in human tissue functions. We examined the pattern of p63 expression in human esophageal squamous cell carcinomas including early-stage cancers, and its clinicopathological significance. Immunoreactivity for p63 was detected in 96.9% (63/65) esophageal squamous cell carcinomas. Diffuse p63 expression was seen in 75.4% (49/65). p63 was detected not only in the in situ carcinomatous components or intramucosal carcinomas, but also in the invasive carcinomatous parts of the p63-positive cases. There were no significant correlations between p63 expression and clinicopathological features, such as depth of tumor invasion, tumor differentiation, lymph node metastasis and venous/lymphatic invasion. We also analyzed the relationship between p63 and p53 expression in esophageal squamous cell carcinomas. These results suggest that the p63 gene, as well as the p53 gene, play a major role in the carcinogenesis of human esophageal squamous cells and in the growth of the carcinoma.

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Copy and paste a formatted citation
Spandidos Publications style
Hara T, Kijima H, Yamamoto S, Kenmochi T, Kise Y, Tanaka H, Chino O, Shimada H, Takazawa K, Tanaka M, Tanaka M, et al: Ubiquitous p63 expression in human esophageal squamous cell carcinoma. Int J Mol Med 14: 169-173, 2004.
APA
Hara, T., Kijima, H., Yamamoto, S., Kenmochi, T., Kise, Y., Tanaka, H. ... Makuuchi, H. (2004). Ubiquitous p63 expression in human esophageal squamous cell carcinoma. International Journal of Molecular Medicine, 14, 169-173. https://doi.org/10.3892/ijmm.14.2.169
MLA
Hara, T., Kijima, H., Yamamoto, S., Kenmochi, T., Kise, Y., Tanaka, H., Chino, O., Shimada, H., Takazawa, K., Tanaka, M., Inokuchi, S., Makuuchi, H."Ubiquitous p63 expression in human esophageal squamous cell carcinoma". International Journal of Molecular Medicine 14.2 (2004): 169-173.
Chicago
Hara, T., Kijima, H., Yamamoto, S., Kenmochi, T., Kise, Y., Tanaka, H., Chino, O., Shimada, H., Takazawa, K., Tanaka, M., Inokuchi, S., Makuuchi, H."Ubiquitous p63 expression in human esophageal squamous cell carcinoma". International Journal of Molecular Medicine 14, no. 2 (2004): 169-173. https://doi.org/10.3892/ijmm.14.2.169
Copy and paste a formatted citation
x
Spandidos Publications style
Hara T, Kijima H, Yamamoto S, Kenmochi T, Kise Y, Tanaka H, Chino O, Shimada H, Takazawa K, Tanaka M, Tanaka M, et al: Ubiquitous p63 expression in human esophageal squamous cell carcinoma. Int J Mol Med 14: 169-173, 2004.
APA
Hara, T., Kijima, H., Yamamoto, S., Kenmochi, T., Kise, Y., Tanaka, H. ... Makuuchi, H. (2004). Ubiquitous p63 expression in human esophageal squamous cell carcinoma. International Journal of Molecular Medicine, 14, 169-173. https://doi.org/10.3892/ijmm.14.2.169
MLA
Hara, T., Kijima, H., Yamamoto, S., Kenmochi, T., Kise, Y., Tanaka, H., Chino, O., Shimada, H., Takazawa, K., Tanaka, M., Inokuchi, S., Makuuchi, H."Ubiquitous p63 expression in human esophageal squamous cell carcinoma". International Journal of Molecular Medicine 14.2 (2004): 169-173.
Chicago
Hara, T., Kijima, H., Yamamoto, S., Kenmochi, T., Kise, Y., Tanaka, H., Chino, O., Shimada, H., Takazawa, K., Tanaka, M., Inokuchi, S., Makuuchi, H."Ubiquitous p63 expression in human esophageal squamous cell carcinoma". International Journal of Molecular Medicine 14, no. 2 (2004): 169-173. https://doi.org/10.3892/ijmm.14.2.169
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