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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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August 2004 Volume 14 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2004 Volume 14 Issue 2

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Article

The Na+/H+ exchange inhibitor HOE642 prevents stress-induced epithelial barrier dysfunction

  • Authors:
    • Peter Nowak
    • Roman Blaheta
    • Alina Schuller
    • Jindrich Cinatl
    • Gerhard Wimmer-Greinecker
    • Anton Moritz
    • Martin Scholz

  • View Affiliations / Copyright

    Affiliations: Klinik für Thorax-, Herz- und thorakale Gefässchirurgie, Johann Wolfgang Goethe-Universität, Frankfurt am Main D-60590, Germany
  • Pages: 175-178
    |
    Published online on: August 1, 2004
       https://doi.org/10.3892/ijmm.14.2.175
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Abstract

Recently, evidence has been obtained that the Na+/H+ exchange (NHE) inhibitor HOE642 may stabilize endothelial and epithelial barrier function in vivo. However, the underlying mechanisms are not known. Therefore, we studied the influence of HOE642 on the barrier function of the epithelial cell line CaCo2. The phorbolester phorbol 12-myristate 13-acetate (PMA) was used to induce hyperpermeability of the epithelial layer which was indirectly determined by measuring the transepithelial electrical resistance (TER). Confocal laser scan microscopy (LSM) served to analyze the intracellular localization of adherens and tight junction molecules. In five independent experiments we found that HOE642 increased TER in non-treated CaCo2 cells (control: 350±28 Ω/cm2; HOE642: 444±53 Ω/cm2) and prevented PMA-induced barrier dysfunction (PMA: 33±12 Ω/cm2; PMA plus HOE642: 496±47 Ω/cm2). LSM showed that HOE642 prevented the PMA-induced disassociation of the zonula adherens molecule β-catenin from the cell membrane and the decreased expression of the zonula occludens molecule ZO-1. From our data we conclude that HOE642 may prevent stress-induced epithelial dysfunction by stabilization of cell membrane-associated junction molecules.

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Copy and paste a formatted citation
Spandidos Publications style
Nowak P, Blaheta R, Schuller A, Cinatl J, Wimmer-Greinecker G, Moritz A and Scholz M: The Na+/H+ exchange inhibitor HOE642 prevents stress-induced epithelial barrier dysfunction. Int J Mol Med 14: 175-178, 2004.
APA
Nowak, P., Blaheta, R., Schuller, A., Cinatl, J., Wimmer-Greinecker, G., Moritz, A., & Scholz, M. (2004). The Na+/H+ exchange inhibitor HOE642 prevents stress-induced epithelial barrier dysfunction. International Journal of Molecular Medicine, 14, 175-178. https://doi.org/10.3892/ijmm.14.2.175
MLA
Nowak, P., Blaheta, R., Schuller, A., Cinatl, J., Wimmer-Greinecker, G., Moritz, A., Scholz, M."The Na+/H+ exchange inhibitor HOE642 prevents stress-induced epithelial barrier dysfunction". International Journal of Molecular Medicine 14.2 (2004): 175-178.
Chicago
Nowak, P., Blaheta, R., Schuller, A., Cinatl, J., Wimmer-Greinecker, G., Moritz, A., Scholz, M."The Na+/H+ exchange inhibitor HOE642 prevents stress-induced epithelial barrier dysfunction". International Journal of Molecular Medicine 14, no. 2 (2004): 175-178. https://doi.org/10.3892/ijmm.14.2.175
Copy and paste a formatted citation
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Spandidos Publications style
Nowak P, Blaheta R, Schuller A, Cinatl J, Wimmer-Greinecker G, Moritz A and Scholz M: The Na+/H+ exchange inhibitor HOE642 prevents stress-induced epithelial barrier dysfunction. Int J Mol Med 14: 175-178, 2004.
APA
Nowak, P., Blaheta, R., Schuller, A., Cinatl, J., Wimmer-Greinecker, G., Moritz, A., & Scholz, M. (2004). The Na+/H+ exchange inhibitor HOE642 prevents stress-induced epithelial barrier dysfunction. International Journal of Molecular Medicine, 14, 175-178. https://doi.org/10.3892/ijmm.14.2.175
MLA
Nowak, P., Blaheta, R., Schuller, A., Cinatl, J., Wimmer-Greinecker, G., Moritz, A., Scholz, M."The Na+/H+ exchange inhibitor HOE642 prevents stress-induced epithelial barrier dysfunction". International Journal of Molecular Medicine 14.2 (2004): 175-178.
Chicago
Nowak, P., Blaheta, R., Schuller, A., Cinatl, J., Wimmer-Greinecker, G., Moritz, A., Scholz, M."The Na+/H+ exchange inhibitor HOE642 prevents stress-induced epithelial barrier dysfunction". International Journal of Molecular Medicine 14, no. 2 (2004): 175-178. https://doi.org/10.3892/ijmm.14.2.175
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