Role of caspase in CD80 expression of superantigen-stimulated monocytes

  • Authors:
    • Fumiaki Shinohara
    • Keiko Sato
    • Maiko Suzuki
    • Haruhiko Takada
    • Seishi Echigo
    • Hidemi Rikiishi
  • View Affiliations

  • Published online on: August 1, 2004     https://doi.org/10.3892/ijmm.14.2.241
  • Pages: 241-246
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Abstract

In this study, we demonstrated evidence for the induction of CD80+ monocytes by staphylococcal enterotoxin B (SEB) via caspase actions. Pre-treatment with pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of NF-κB, resulted in a significant reduction in the percentage of SEB- and interferon-γ (IFN-γ) (produced by SEB) -induced CD80+ monocytes. SEB and IFN-γ activated NF-κB, which was inhibited by PDTC. SEB induced the activation of caspase-3 and -8, and pre-treatment with z-VAD-fmk, a broad-spectrum inhibitor of caspases, prevented the induction of apoptosis. Treating with z-VAD-fmk resulted in a reduction of the generation of CD80+ monocytes. These results indicated that CD80 driven by NF-κB is regulated by the enzymatic actions of caspases, which allows monocytes to participate in massive T-cell activation.

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August 2004
Volume 14 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Shinohara F, Sato K, Suzuki M, Takada H, Echigo S and Rikiishi H: Role of caspase in CD80 expression of superantigen-stimulated monocytes. Int J Mol Med 14: 241-246, 2004
APA
Shinohara, F., Sato, K., Suzuki, M., Takada, H., Echigo, S., & Rikiishi, H. (2004). Role of caspase in CD80 expression of superantigen-stimulated monocytes. International Journal of Molecular Medicine, 14, 241-246. https://doi.org/10.3892/ijmm.14.2.241
MLA
Shinohara, F., Sato, K., Suzuki, M., Takada, H., Echigo, S., Rikiishi, H."Role of caspase in CD80 expression of superantigen-stimulated monocytes". International Journal of Molecular Medicine 14.2 (2004): 241-246.
Chicago
Shinohara, F., Sato, K., Suzuki, M., Takada, H., Echigo, S., Rikiishi, H."Role of caspase in CD80 expression of superantigen-stimulated monocytes". International Journal of Molecular Medicine 14, no. 2 (2004): 241-246. https://doi.org/10.3892/ijmm.14.2.241