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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
August 2004 Volume 14 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2004 Volume 14 Issue 2

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Article

Adenoviral-mediated transfer of p53 gene enhances TRAIL-induced apoptosis in human hepatocellular carcinoma cells

  • Authors:
    • Hidekazu Inoue
    • Katsuya Shiraki
    • Kazumoto Murata
    • Kazushi Sugimoto
    • Tomoyuki Kawakita
    • Yumi Yamaguchi
    • Yukiko Saitou
    • Naoyuki Enokimura
    • Norihiko Yamamoto
    • Yutaka Yamanaka
    • Takeshi Nakano

  • View Affiliations / Copyright

    Affiliations: First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514-8507, Japan
  • Pages: 271-275
    |
    Published online on: August 1, 2004
       https://doi.org/10.3892/ijmm.14.2.271
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Abstract

p53 is a tumor suppressor protein with numerous biological functions including transformation, regulation of cell growth, differentiation and apoptosis. The TNF-related apoptosis-inducing ligand (TRAIL) can induce apoptosis in various transformed cell lines. We investigated the effects of combining wild-type p53 gene transduction by adenoviral infection (Ad-p53) with addition of TRAIL on cell death, expression levels of TRAIL receptors (TRAIL-R1, TRAIL-R2), FLICE inhibitory protein (FLIP) and X-linked inhibitor of apoptosis protein (XIAP) on human hepatocellular carcinoma (HCC) cell lines. HCC cell death was increased by combination of Ad-p53 infection and addition of TRAIL compared to either alone. Western blotting demonstrated decreased TRAIL-R1 and TRAIL-R2 levels after infection with Ad-p53. FLIP levels decreased in Huh7 cells and Hep3B cells, and XIAP levels decreased in all three HCC cell lines after infection with Ad-p53. Thus, death of HCC cells due to combined p53 gene transduction and exogenous TRAIL may be due to down regulation of FLIP or XIAP.

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Copy and paste a formatted citation
Spandidos Publications style
Inoue H, Shiraki K, Murata K, Sugimoto K, Kawakita T, Yamaguchi Y, Saitou Y, Enokimura N, Yamamoto N, Yamanaka Y, Yamanaka Y, et al: Adenoviral-mediated transfer of p53 gene enhances TRAIL-induced apoptosis in human hepatocellular carcinoma cells. Int J Mol Med 14: 271-275, 2004.
APA
Inoue, H., Shiraki, K., Murata, K., Sugimoto, K., Kawakita, T., Yamaguchi, Y. ... Nakano, T. (2004). Adenoviral-mediated transfer of p53 gene enhances TRAIL-induced apoptosis in human hepatocellular carcinoma cells. International Journal of Molecular Medicine, 14, 271-275. https://doi.org/10.3892/ijmm.14.2.271
MLA
Inoue, H., Shiraki, K., Murata, K., Sugimoto, K., Kawakita, T., Yamaguchi, Y., Saitou, Y., Enokimura, N., Yamamoto, N., Yamanaka, Y., Nakano, T."Adenoviral-mediated transfer of p53 gene enhances TRAIL-induced apoptosis in human hepatocellular carcinoma cells". International Journal of Molecular Medicine 14.2 (2004): 271-275.
Chicago
Inoue, H., Shiraki, K., Murata, K., Sugimoto, K., Kawakita, T., Yamaguchi, Y., Saitou, Y., Enokimura, N., Yamamoto, N., Yamanaka, Y., Nakano, T."Adenoviral-mediated transfer of p53 gene enhances TRAIL-induced apoptosis in human hepatocellular carcinoma cells". International Journal of Molecular Medicine 14, no. 2 (2004): 271-275. https://doi.org/10.3892/ijmm.14.2.271
Copy and paste a formatted citation
x
Spandidos Publications style
Inoue H, Shiraki K, Murata K, Sugimoto K, Kawakita T, Yamaguchi Y, Saitou Y, Enokimura N, Yamamoto N, Yamanaka Y, Yamanaka Y, et al: Adenoviral-mediated transfer of p53 gene enhances TRAIL-induced apoptosis in human hepatocellular carcinoma cells. Int J Mol Med 14: 271-275, 2004.
APA
Inoue, H., Shiraki, K., Murata, K., Sugimoto, K., Kawakita, T., Yamaguchi, Y. ... Nakano, T. (2004). Adenoviral-mediated transfer of p53 gene enhances TRAIL-induced apoptosis in human hepatocellular carcinoma cells. International Journal of Molecular Medicine, 14, 271-275. https://doi.org/10.3892/ijmm.14.2.271
MLA
Inoue, H., Shiraki, K., Murata, K., Sugimoto, K., Kawakita, T., Yamaguchi, Y., Saitou, Y., Enokimura, N., Yamamoto, N., Yamanaka, Y., Nakano, T."Adenoviral-mediated transfer of p53 gene enhances TRAIL-induced apoptosis in human hepatocellular carcinoma cells". International Journal of Molecular Medicine 14.2 (2004): 271-275.
Chicago
Inoue, H., Shiraki, K., Murata, K., Sugimoto, K., Kawakita, T., Yamaguchi, Y., Saitou, Y., Enokimura, N., Yamamoto, N., Yamanaka, Y., Nakano, T."Adenoviral-mediated transfer of p53 gene enhances TRAIL-induced apoptosis in human hepatocellular carcinoma cells". International Journal of Molecular Medicine 14, no. 2 (2004): 271-275. https://doi.org/10.3892/ijmm.14.2.271
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