Structural organization of the mouse neurochondrin gene

  • Authors:
    • Reiko Mochizuki-Sakisaka
    • Minori Dateki
    • Yasuyuki Ishizuka
    • Kazuyuki Yanai
    • Yoichi Matsuda
    • Yoshihiko Koga
    • Akiyoshi Fukamizu
  • View Affiliations

  • Published online on: September 1, 2004     https://doi.org/10.3892/ijmm.14.3.361
  • Pages: 361-366
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Abstract

Neurochondrin is a brain and bone specific leucine-rich protein. We previously cloned the two types of mRNAs (neurochondrin-1; 729 amino acids and neurochondrin-2; 712 amino acids) from mouse and human species. As a first step, to better understand the mechanism of the bone and brain specific and developmentally regulated expression of the neruochondrin gene, the genomic organization of murine neurochondrin was determined. It consists of 7 exons and spans about 10 kb; all splice junctions conform to the GT/AG rule. It codes for two alternatively spliced messenger RNAs, neurochondrin-1 containing all 7 exons and neurochondrin-2 lacking exon 1b but containing the other exons. Cap site analysis showed that the major transcription initiation occurs at 765 bp upstream of the ATG start codon of neurochondrin-1. The promoter region has no TATA and CAAT box-like sequence but contains potential AP-1 and SP-1 binding sites. The neurochondrin gene is localized to mouse chromosome 4D1 and rat chromosome 5q36.11.

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September 2004
Volume 14 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Mochizuki-Sakisaka R, Dateki M, Ishizuka Y, Yanai K, Matsuda Y, Koga Y and Fukamizu A: Structural organization of the mouse neurochondrin gene. Int J Mol Med 14: 361-366, 2004
APA
Mochizuki-Sakisaka, R., Dateki, M., Ishizuka, Y., Yanai, K., Matsuda, Y., Koga, Y., & Fukamizu, A. (2004). Structural organization of the mouse neurochondrin gene. International Journal of Molecular Medicine, 14, 361-366. https://doi.org/10.3892/ijmm.14.3.361
MLA
Mochizuki-Sakisaka, R., Dateki, M., Ishizuka, Y., Yanai, K., Matsuda, Y., Koga, Y., Fukamizu, A."Structural organization of the mouse neurochondrin gene". International Journal of Molecular Medicine 14.3 (2004): 361-366.
Chicago
Mochizuki-Sakisaka, R., Dateki, M., Ishizuka, Y., Yanai, K., Matsuda, Y., Koga, Y., Fukamizu, A."Structural organization of the mouse neurochondrin gene". International Journal of Molecular Medicine 14, no. 3 (2004): 361-366. https://doi.org/10.3892/ijmm.14.3.361