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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2004 Volume 14 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2004 Volume 14 Issue 4

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Article

Expression of interleukin-6 in human craniopharyngiomas: a possible inducer of tumor-associated inflammation.

  • Authors:
    • Masanao Mori
    • Hideo Takeshima
    • Jun-ichi Kuratsu

  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan.
  • Pages: 505-514
    |
    Published online on: October 1, 2004
       https://doi.org/10.3892/ijmm.14.4.505
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Abstract

The total removal of craniopharyngiomas can be difficult because of their tendency to adhere to surrounding vital structures. Frequently, adjacent brain tissue is infiltrated by leukocytes and cytokine(s) produced by tumor cells may play a pivotal role in tissue reaction. To elucidate the molecular mechanism(s) underlying such local inflammation, we investigated the expression of interleukin (IL)-1alpha, interleukin (IL)-6, and tumor necrosis factor (TNF)-alpha in 15 craniopharyngiomas using a combination of RT-PCR, immunoblots, and immunohistochemistry. Although RT-PCR detected the expression of IL-1alpha, IL-6, and TNF-alpha, immunoblots demonstrated remarkable protein expression only for IL-6. Immunohistochemical study found that the epithelial cell layer was strongly immunoreactive for IL-6. Tumor cell layers stained weakly or negatively for IL-1alpha and TNF-alpha. Sandwich ELISA showed that levels of IL-1alpha and TNF-alpha were significantly higher in the cyst fluid than in cerebrospinal fluid (CSF) but lower than 10-fold. As the concentration of IL-6 in cyst fluid was >50,000 times that in CSF, we suggest that IL-6 plays an important role in the inflammatory reaction that occurs in the interface between the craniopharyngioma and the brain parenchyma.

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Copy and paste a formatted citation
Spandidos Publications style
Mori M, Takeshima H and Kuratsu J: Expression of interleukin-6 in human craniopharyngiomas: a possible inducer of tumor-associated inflammation.. Int J Mol Med 14: 505-514, 2004.
APA
Mori, M., Takeshima, H., & Kuratsu, J. (2004). Expression of interleukin-6 in human craniopharyngiomas: a possible inducer of tumor-associated inflammation.. International Journal of Molecular Medicine, 14, 505-514. https://doi.org/10.3892/ijmm.14.4.505
MLA
Mori, M., Takeshima, H., Kuratsu, J."Expression of interleukin-6 in human craniopharyngiomas: a possible inducer of tumor-associated inflammation.". International Journal of Molecular Medicine 14.4 (2004): 505-514.
Chicago
Mori, M., Takeshima, H., Kuratsu, J."Expression of interleukin-6 in human craniopharyngiomas: a possible inducer of tumor-associated inflammation.". International Journal of Molecular Medicine 14, no. 4 (2004): 505-514. https://doi.org/10.3892/ijmm.14.4.505
Copy and paste a formatted citation
x
Spandidos Publications style
Mori M, Takeshima H and Kuratsu J: Expression of interleukin-6 in human craniopharyngiomas: a possible inducer of tumor-associated inflammation.. Int J Mol Med 14: 505-514, 2004.
APA
Mori, M., Takeshima, H., & Kuratsu, J. (2004). Expression of interleukin-6 in human craniopharyngiomas: a possible inducer of tumor-associated inflammation.. International Journal of Molecular Medicine, 14, 505-514. https://doi.org/10.3892/ijmm.14.4.505
MLA
Mori, M., Takeshima, H., Kuratsu, J."Expression of interleukin-6 in human craniopharyngiomas: a possible inducer of tumor-associated inflammation.". International Journal of Molecular Medicine 14.4 (2004): 505-514.
Chicago
Mori, M., Takeshima, H., Kuratsu, J."Expression of interleukin-6 in human craniopharyngiomas: a possible inducer of tumor-associated inflammation.". International Journal of Molecular Medicine 14, no. 4 (2004): 505-514. https://doi.org/10.3892/ijmm.14.4.505
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