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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2004 Volume 14 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2004 Volume 14 Issue 4

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Article

Apolipoprotein E as vascular risk factor in neurodegenerative dementia.

  • Authors:
    • Marcella Folin
    • Silvia Baiguera
    • Maria Teresa Conconi
    • Rosa Di Liddo
    • Eugenio De Carlo
    • Pier Paolo Parnigotto
    • Gastone G Nussdorfer

  • View Affiliations / Copyright

    Affiliations: Department of Biology, University of Padua, Via Gabelli 65, I-35121 Padua, Italy.
  • Pages: 609-622
    |
    Published online on: October 1, 2004
       https://doi.org/10.3892/ijmm.14.4.609
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Abstract

Apolipoprotein E (ApoE) is the major lipid-carrier protein in the brain, and several studies provided evidence that ApoE epsilon4 allele can be considered a genetic risk factor for vascular diseases. Findings indicate that Alzheimer disease (AD) and vascular dementia (VaD) may have common risk factors and/or pathogenesis, but their interrelationships still need to be clearly defined. Since ApoE4 imparts risk for both hyperlipidemia and AD, it seemed worthwhile to investigate the possible role of ApoE in the pathogenesis of AD and VaD. To this task, we examined in healthy volunteers, and AD and VaD patients: i) the frequency of ApoE isoforms; and ii) the influence of ApoE genotype on serum lipid levels. Our findings suggest that epsilon4 allele is an important risk factor for the development not only of the Alzheimer type, but also of the vascular type of dementia. In contrast, epsilon2 allele could have a protective role in AD dementia. These results confirm the hypothesis that serum ApoE concentration is dependent on ApoE genotype, but do not support the view that it has to be considered a relevant biochemical marker for AD and VaD.

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Copy and paste a formatted citation
Spandidos Publications style
Folin M, Baiguera S, Conconi M, Di Liddo R, De Carlo E, Parnigotto P and Nussdorfer G: Apolipoprotein E as vascular risk factor in neurodegenerative dementia.. Int J Mol Med 14: 609-622, 2004.
APA
Folin, M., Baiguera, S., Conconi, M., Di Liddo, R., De Carlo, E., Parnigotto, P., & Nussdorfer, G. (2004). Apolipoprotein E as vascular risk factor in neurodegenerative dementia.. International Journal of Molecular Medicine, 14, 609-622. https://doi.org/10.3892/ijmm.14.4.609
MLA
Folin, M., Baiguera, S., Conconi, M., Di Liddo, R., De Carlo, E., Parnigotto, P., Nussdorfer, G."Apolipoprotein E as vascular risk factor in neurodegenerative dementia.". International Journal of Molecular Medicine 14.4 (2004): 609-622.
Chicago
Folin, M., Baiguera, S., Conconi, M., Di Liddo, R., De Carlo, E., Parnigotto, P., Nussdorfer, G."Apolipoprotein E as vascular risk factor in neurodegenerative dementia.". International Journal of Molecular Medicine 14, no. 4 (2004): 609-622. https://doi.org/10.3892/ijmm.14.4.609
Copy and paste a formatted citation
x
Spandidos Publications style
Folin M, Baiguera S, Conconi M, Di Liddo R, De Carlo E, Parnigotto P and Nussdorfer G: Apolipoprotein E as vascular risk factor in neurodegenerative dementia.. Int J Mol Med 14: 609-622, 2004.
APA
Folin, M., Baiguera, S., Conconi, M., Di Liddo, R., De Carlo, E., Parnigotto, P., & Nussdorfer, G. (2004). Apolipoprotein E as vascular risk factor in neurodegenerative dementia.. International Journal of Molecular Medicine, 14, 609-622. https://doi.org/10.3892/ijmm.14.4.609
MLA
Folin, M., Baiguera, S., Conconi, M., Di Liddo, R., De Carlo, E., Parnigotto, P., Nussdorfer, G."Apolipoprotein E as vascular risk factor in neurodegenerative dementia.". International Journal of Molecular Medicine 14.4 (2004): 609-622.
Chicago
Folin, M., Baiguera, S., Conconi, M., Di Liddo, R., De Carlo, E., Parnigotto, P., Nussdorfer, G."Apolipoprotein E as vascular risk factor in neurodegenerative dementia.". International Journal of Molecular Medicine 14, no. 4 (2004): 609-622. https://doi.org/10.3892/ijmm.14.4.609
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