Apolipoprotein E as vascular risk factor in neurodegenerative dementia.

  • Authors:
    • Marcella Folin
    • Silvia Baiguera
    • Maria Teresa Conconi
    • Rosa Di Liddo
    • Eugenio De Carlo
    • Pier Paolo Parnigotto
    • Gastone G Nussdorfer
  • View Affiliations

  • Published online on: October 1, 2004     https://doi.org/10.3892/ijmm.14.4.609
  • Pages: 609-622
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Abstract

Apolipoprotein E (ApoE) is the major lipid-carrier protein in the brain, and several studies provided evidence that ApoE epsilon4 allele can be considered a genetic risk factor for vascular diseases. Findings indicate that Alzheimer disease (AD) and vascular dementia (VaD) may have common risk factors and/or pathogenesis, but their interrelationships still need to be clearly defined. Since ApoE4 imparts risk for both hyperlipidemia and AD, it seemed worthwhile to investigate the possible role of ApoE in the pathogenesis of AD and VaD. To this task, we examined in healthy volunteers, and AD and VaD patients: i) the frequency of ApoE isoforms; and ii) the influence of ApoE genotype on serum lipid levels. Our findings suggest that epsilon4 allele is an important risk factor for the development not only of the Alzheimer type, but also of the vascular type of dementia. In contrast, epsilon2 allele could have a protective role in AD dementia. These results confirm the hypothesis that serum ApoE concentration is dependent on ApoE genotype, but do not support the view that it has to be considered a relevant biochemical marker for AD and VaD.

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October 2004
Volume 14 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Folin M, Baiguera S, Conconi M, Di Liddo R, De Carlo E, Parnigotto P and Nussdorfer G: Apolipoprotein E as vascular risk factor in neurodegenerative dementia.. Int J Mol Med 14: 609-622, 2004
APA
Folin, M., Baiguera, S., Conconi, M., Di Liddo, R., De Carlo, E., Parnigotto, P., & Nussdorfer, G. (2004). Apolipoprotein E as vascular risk factor in neurodegenerative dementia.. International Journal of Molecular Medicine, 14, 609-622. https://doi.org/10.3892/ijmm.14.4.609
MLA
Folin, M., Baiguera, S., Conconi, M., Di Liddo, R., De Carlo, E., Parnigotto, P., Nussdorfer, G."Apolipoprotein E as vascular risk factor in neurodegenerative dementia.". International Journal of Molecular Medicine 14.4 (2004): 609-622.
Chicago
Folin, M., Baiguera, S., Conconi, M., Di Liddo, R., De Carlo, E., Parnigotto, P., Nussdorfer, G."Apolipoprotein E as vascular risk factor in neurodegenerative dementia.". International Journal of Molecular Medicine 14, no. 4 (2004): 609-622. https://doi.org/10.3892/ijmm.14.4.609