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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2004 Volume 14 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2004 Volume 14 Issue 4

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Article

Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells.

  • Authors:
    • Jianwu Wang
    • Yuanjing Yu
    • Fumio Hashimoto
    • Yusuke Sakata
    • Makoto Fujii
    • De-Xing Hou

  • View Affiliations / Copyright

    Affiliations: Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University, Korimoto 1-21-24, Kagoshima 890-0065, Japan.
  • Pages: 627-659
    |
    Published online on: October 1, 2004
       https://doi.org/10.3892/ijmm.14.4.627
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Abstract

Baicalein is one component of the dried root of Scutellaria Baicalensis Georgi. (Huang Qin) which is widely used in the traditional Chinese herbal medicine. In this study, we report that baicalein was able to induce apoptosis in human promyelocytic leukemia cells (HL-60), as characterized by poly-(ADP-ribose) polymerase (PARP) cleavage and DNA fragmentation. The efficacious induction of apoptosis was observed at 100 microM for 6 h. Mechanistic analysis demonstrated that baicalein induced the cleavage of Bid protein, cytochrome c release from mitochondria into cytosol, and activation of caspase-3, -8 and -9. Moreover, baicalein caused elevation of intracellular hydrogen peroxide level. Catalase could effectively block baicalein-induced DNA fragmentation. These data indicate that baicalein may trigger an apoptotic death program through reactive oxygen species (ROS)-mediated mitochondrial dysfunction pathway. The findings enhance our understanding of anticancer function of baicalein in herbal medicine.

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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Yu Y, Hashimoto F, Sakata Y, Fujii M and Hou D: Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells.. Int J Mol Med 14: 627-659, 2004.
APA
Wang, J., Yu, Y., Hashimoto, F., Sakata, Y., Fujii, M., & Hou, D. (2004). Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells.. International Journal of Molecular Medicine, 14, 627-659. https://doi.org/10.3892/ijmm.14.4.627
MLA
Wang, J., Yu, Y., Hashimoto, F., Sakata, Y., Fujii, M., Hou, D."Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells.". International Journal of Molecular Medicine 14.4 (2004): 627-659.
Chicago
Wang, J., Yu, Y., Hashimoto, F., Sakata, Y., Fujii, M., Hou, D."Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells.". International Journal of Molecular Medicine 14, no. 4 (2004): 627-659. https://doi.org/10.3892/ijmm.14.4.627
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Yu Y, Hashimoto F, Sakata Y, Fujii M and Hou D: Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells.. Int J Mol Med 14: 627-659, 2004.
APA
Wang, J., Yu, Y., Hashimoto, F., Sakata, Y., Fujii, M., & Hou, D. (2004). Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells.. International Journal of Molecular Medicine, 14, 627-659. https://doi.org/10.3892/ijmm.14.4.627
MLA
Wang, J., Yu, Y., Hashimoto, F., Sakata, Y., Fujii, M., Hou, D."Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells.". International Journal of Molecular Medicine 14.4 (2004): 627-659.
Chicago
Wang, J., Yu, Y., Hashimoto, F., Sakata, Y., Fujii, M., Hou, D."Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells.". International Journal of Molecular Medicine 14, no. 4 (2004): 627-659. https://doi.org/10.3892/ijmm.14.4.627
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